Development of bio-assay system of HTLV-1 infection using xenograft model mice
Project/Area Number |
22590532
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Laboratory medicine
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Research Institution | University of Miyazaki |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TAKAJO Ichiro 宮崎大学, 医学部, 講師 (20418841)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | HTLV-1 / ATL / NOGマウス / ゼノグラフトモデル / 感染予防 / 発症予防 |
Research Abstract |
HTLV-1 is a causative agent of adult T-cell leukemia. In the present study, we tried to clarify the mechanism of cell to cell infection and clonal evolution of HTLV-1 infected cells using xenograft model of mice. The HTLV-1 infected cells from asymptomatic carriers survived and proliferated in NOG mice. The HTLV-1 proviral loads were higher when the PBMCs from long-term carriers were inoculated to the mice. Moreover, NOG mice,which received the sera from carriers or neutralizing antibodies, had decreased proviral loads and limited clonal proliferation of HTLV-1 infected cells. These data suggested this mouse model provide the novel information of themechanism of HTLV-1 infection and may be applicable for the risk assessment of ATL development from HTLV-1 carriers.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma2012
Author(s)
Nakahata S, Saito Y, Marutsuka K, Hidaka T, Maeda K, Hatakeyama K, Shiraga T, Goto A, Takamatsu N, Asada Y, Utsunomiya A, Okayama A, Kubuki Y, Shimoda K, Ukai Y, Kurosawa G, Morishita K
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Journal Title
Leukemia
Volume: Jan;26 (6)
Issue: 6
Pages: 1238-46
DOI
Related Report
Peer Reviewed
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[Journal Article] Defective human T-lymphotropic virus type 1 provirus in asymptomatic carriers.2011
Author(s)
Takenouchi H, Umeki K, Sasaki D, Yamamoto I, Nomura H, Takajo I, Ueno S, Umekita K, Kamihira S, Morishita K, Okayama A.
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Journal Title
International Journal of Cancer
Volume: 128(6)
Pages: 1335-1343
Related Report
Peer Reviewed
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[Journal Article] Downregulation of CDKN1A in Adult T-Cell Leukemia/Lymphoma despite Overexpression of CDKN1A in Human T-Lymphotropic Virus 1-Infected Cell Lines.2010
Author(s)
Watanabe M, Nakahata S, Hamasaki M, Saito Y, Kawano Y, Hidaka T, Yamashita K, Umeki K, Taki T, Taniwaki M, Okayama A, Morishita K.
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Journal Title
Journal of Virology.
Volume: 84(14)
Pages: 6966-6977
Related Report
Peer Reviewed
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[Journal Article] Human T-cell Leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers : a nationwibe prospective study in Japan.2010
Author(s)
Iwanaga M, Watanabe T, Utsuno miya A, Okayama A, Uchimaru K, Ki-Ryang Koh, Ogata M, Kikuchi H, Sagara Y, Uozumi K, Mochizuki M, Tsukasaki K, Saburi Y, Yamamura M, Tanaka J, Moriuchi Y, Hino S, Kamihira S, Yamaguchi K, for the Joint Study on Predisposing Factors of ATL Development investigators.
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Journal Title
BLOOD
Volume: 116(8)
Pages: 1211-1219
Related Report
Peer Reviewed
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[Journal Article] Intra- and inter-laboratory variability in human T-cell leukemia virus type-1 proviral load quantification using real-time polymerase chain reaction assays : A multi-center study.2010
Author(s)
Kamihira S, Yamano Y, Iwanaga M, Sasaki D, Satake M, Okayama A, Umeki K, Kubota R, Izumo S, Yamaguchi K, Watanabe T.
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Journal Title
Cancer Science
Volume: 101(11)
Pages: 2361-2367
NAID
Related Report
Peer Reviewed
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