New diagnostic method and personalized biomarker using circulating nucleic acids in patients with digestive system cancer
| Project/Area Number |
22590533
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | バイオマーカー / 腫瘍マーカー / microRNA / 消化器癌 / 血漿 / 循環核酸 / 術後マーカー / 個別化 |
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| Research Abstract |
This study found that cell-free DNA and microRNA stably exist in the peripheral blood of patients with digestive tract cancers, and detections of tumor-specific abnormalities in the circulating nucleic acids reflect tumor dynamics of primary lesions to some de gree. This study also indicated that detection of tumor-specific amplification and microRNA in the peripheral blood could be useful as not only complementary tumor markers but also prognostic markers for digestive tract cancers.
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Report
(4 results)
Research Products
(20 results)
