Analysis of prognostic predictor for papillary thyroid carcinoma

Research Project

Project/Area Number	22590536
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Laboratory medicine
Research Institution	Juntendo University
Principal Investigator	SHIMIZU Tomoaki 順天堂大学, 医学部, 准教授 (30384077)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	甲状腺乳頭癌 / BRAF 遺伝子異常 / 臨床的悪性度 / 甲状腺微少乳頭癌 / BRAF遺伝子変異 / B-raf遺伝子異常 / B-raf / 突然変異
Research Abstract	Analysis of BRAF mutation in papillary thyroid carcinoma using Fine-needle aspiration (FNA) sample is established in recent 3 years. We showed the relationship between BRAF mutation (T1796A) and clinical malignancy of Japanese PTC using FNA sample. In surgical PTC tissue,BRAF mutation (T1796A) is positive or negative, the direct sequence method revealed PTC with positive BRAF mutation had heterogeneous alleles. We are going to exclude wild type allele such as blood cells, mesenchymal cells and endothelial cells, further investigate the genetic heterogeneity .