Molecular epidemiology of metabolic syndrome and atherosclerosis initiating from genome wide association study

• Project/Area Number: 22590547
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MURAMATSU Masaaki 東京医科歯科大学, 難治疾患研究所, 教授 (50230008)
• Co-Investigator(Renkei-kenkyūsha): SAWABE Motoji 東京医科歯科大学, 教授 (30196331) ; MIYAKI Koici 国立国際医療センター研究所, 医療情報解析研究部, 室長 (20327498)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: メタボリック症候群 / 動脈硬化症 / ゲノムワイド関連解析 / 遺伝因子と環境因子 / 交互作用 / 遺伝子多型 / 心筋梗塞 / 冠動脈疾患 / 疾患感受性遺伝子 / 遺伝子-環境因子交互作用 / エネルギー摂取量 / 食事調査 / 環境因子 / 高血圧 / 糖尿病 / コホート研究

Research Abstract

We evaluated susceptibility genes/variations for metabolic syndrome and myocardial infarction in Japanese population, which were primarily found by GWAS in western population. We replicated some of their results in different phenotypes of metabolic syndrome, and also found novel gene-environment and gene-gene interactions in Japanese cohort. The effect of risk gene for myocardial infarction may be different between western and Japanese population.

Research Products

• [Journal Article] Thecombined impact of 12 common variants on hypertension in Japanese men, considering GWAS results (2012)
  • Author(s): Miyaki K, Htun NC, Song Y, Ikeda S, Muramatsu M, Shimbo T
  • Journal Title: J Hum Hypertens Volume: 26 Pages: 430-436
• [Journal Article] Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis a pathological study of1503 consecutive autopsy cases (2012)
  • Author(s): Ikeda S, Tanaka N, Arai T, Chida K, Muramatsu M, Sawabe M
  • Journal Title: Atherosclerosis Volume: 221 Pages: 458-60
• [Journal Article] J Atheroscler Thromb (2012)
  • Author(s): Ko MK, Ikeda S, Mieno-Naka M, Arai T, Zaidi SA, Sato N, Muramatsu M,Sawabe M
  • Journal Title: Association of COMT gene polymorphisms with systemic atherosclerosis in elderly Japanese Volume: 19 Pages: 552-8
• [Journal Article] Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis : A pathological study of 1503 consecutive autopsy cases (2012)
  • Author(s): Ikeda S, Sawabe M, et al
  • Journal Title: Atherosclerosis Volume: 221 Issue: 2 Pages: 221-221
  • DOI: 10.1016/j.atherosclerosis.2012.01.003
  • Peer Reviewed
• [Journal Article] Association of COMT gene polymorphisms with systemic atherosclerosis in elderly Japanese. (2012)
  • Author(s): Ko MK, Ikeda S, Mieno-Naka M, Arai T, Zaidi SA, Sato N, Muramatsu M, Sawabe M.
  • Journal Title: J Atheroscler Thromb Volume: 19 Pages: 552-558
  • NAID: 130004444609
  • Peer Reviewed
• [Journal Article] Association of the catechol-O-methyl transferase gene Val158Met polymorphism with blood pressure and prevalence of hypertension: interaction with dietary energy intake (2011)
  • Author(s): Htun NC, Miyaki K, Song Y, Ikeda S, Shimbo T, Muramatsu M
  • Journal Title: Am J Hypertens Volume: 24 Pages: 1022-1026
• [Journal Article] The combined impact of 12 common variants on hypertension in Japanese men, considering GWAS results (2011)
  • Author(s): Miyaki, et al
  • Journal Title: J Hum Hypertens Volume: (epub ahead of print) Issue: 7 Pages: 430-436
  • DOI: 10.1038/jhh.2011.50
  • Peer Reviewed
• [Journal Article] Association of the COMT gene V158M polymorphism with blood pressure and prevalence of hypertension : interaction with dietary energy intake (2011)
  • Author(s): Htun NC, et al
  • Journal Title: Am J Hypertens Volume: 24 Issue: 9 Pages: 1022-1026
  • DOI: 10.1038/ajh.2011.93
  • Peer Reviewed
• [Journal Article] Association of a cyclin-dependent kirnase 5 regulatory subunit-associated protein 1-like 1(CDKAL1)polymorphism with elevated hemoglobin Alc levels and the prevalence of metabolic syndrome in Japanese men (2010)
  • Author(s): Miyaki K, et al.
  • Journal Title: Am.J.Epidemiol Volume: 172 Pages: 985-991
  • Peer Reviewed
• [Journal Article] Respond to "Gene x Lifestyle Interactions" (2010)
  • Author(s): Miyaki K, et al.
  • Journal Title: Am.J.Epidemiol Volume: 172 Pages: 998-999
  • Peer Reviewed
• [Journal Article] CYP3A5 polymorphism and sensitivity of Blood Pressure to dietary salt (2010)
  • Author(s): Zhang L., et al.
  • Journal Title: J.Hum.Hypertens. Volume: 24 Pages: 345-350
  • Peer Reviewed
• [Presentation] Genome Wide Association Study and Pathway Analysis (GWASPA) of atherosclerosis in three distinct arterial system (2012)
  • Author(s): Syed Ali Zaidi, Soichi Ogishima, Hiroshi Tanaka, Noriko Sato and Masaaki Muramatsu
  • Organizer: 生命医薬情報学連合大会
  • Place of Presentation: 東京
• [Presentation] 他日本人高齢者における心筋梗塞関連遺伝子多型の冠動脈狭窄に対する影響 (2011)
  • Author(s): 池田仁子
  • Organizer: 日本人類遺伝学会第56回大会
  • Place of Presentation: 幕張
  • Year and Date: 2011-10-12
• [Presentation] Genetic Tests for Common Diseases and Its Implications (2011)
  • Author(s): Muramatsu M
  • Organizer: 2^<nd> World DNA and Genome Day
  • Place of Presentation: Dalian, China
  • Year and Date: 2011-04-25
• [Presentation] Gene environment interactions in metabolic syndrome and genetic tests (2010)
  • Author(s): Muramatsu M
  • Organizer: 13th A-IMBN Symposium
  • Place of Presentation: 台北
  • Year and Date: 2010-11-11
• [Presentation] Nutrigenomics of MetabolicSyndrome (2010)
  • Author(s): Muramatsu M
  • Organizer: Aesthetics Asia2010
  • Place of Presentation: Singapore
• [Presentation] Gene-environment interactions in metabolic syndrome andgenetic tests (2010)
  • Author(s): Muramatsu M
  • Organizer: 13th A-IMBN Symposium
  • Place of Presentation: Taipei
• [Book] 「遺伝子予防医療に対する期待」ウェルエイジングのための女性医療 (2011)
  • Author(s): 太田博明
  • Publisher: 村松正明