Development of new method for allergen sensitization to mice lung.

• Project/Area Number: 22590549
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Kochi University
• Principal Investigator: HIROTA Ryoji 高知大学, 教育研究部医療学系, 講師 (20448385)
• Co-Investigator(Kenkyū-buntansha): 菅沼 成文 高知大学, 教育研究部医療学系, 教授 (50313747) ; 栄徳 勝光 高知大学, 教育研究部医療学系, 助教 (50552733)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 喘息マウスモデル / ダニ抗原 / 芳香族類炭化水素 / ストレスフリー / ディーゼル / ディーゼル排気ガス / 気管支喘息モデルマウス / 気道抵抗 / 芳香族炭化水素類 / 重金属 / 生分解性のポリマー / 非拘束 / アレルギー

Research Abstract

We tried to develop the new method for making asthmatic mice which could be done a single instillation of allergen. This method can reduce much stress during instillation of allergen to mice. While mice were shown the asthmatic symptoms and histological changes, these responces were weak. Our method needs to update for this purpose.

Research Products

• [Journal Article] Limonene Inhalation Reduces A--ergic Airway Inflammation in Dermatophagoides farinae-treated Mice (2012)
  • Author(s): HIROTA R, NAKAMURA H, Bhatti SA
  • Journal Title: Inhalation toxicology Pages: 373-381
  • Peer Reviewed
• [Journal Article] Propolis Inhalation Reduces Allergic Airway Inflammation in Dermatophagoides farinae -treated Mice (2012)
  • Author(s): HIROTA R, NGATU NR, NAKAMURA H, SUGANUMA N
  • Journal Title: J Prev. Med Pages: 95-102
  • NAID: 40019551917
  • Peer Reviewed
• [Journal Article] Limonene inhalation reduces allergic airway inflammation in Dermatophagoides farinae-treated mice (2012)
  • Author(s): Hirota R, Nakamura H, Bhatti SA, Ngatu NR, Muzembo BA, Dumavibhat N, Eitoku M, Sawamura M, Suganuma N
  • Journal Title: Inhal Toxicol Volume: 24(6) Issue: 6 Pages: 373-381
  • DOI: 10.3109/08958378.2012.675528
  • Peer Reviewed
• [Journal Article] Propolis Inhalation Reduces Allergic Airway Inflammation in Dermatophagoides farinae -treated Mice. (2012)
  • Author(s): HIROTA R, NGATU NR, NAKAMURA H, SUGANUMA N.
  • Journal Title: J Prev. Med. Volume: 7 Pages: 95-102
  • NAID: 40019551917
  • Peer Reviewed
• [Journal Article] Brazilian green propolis extracts improve Tinea pedis interdigitalis and Tinea corporis (IF=1.498) (2012)
  • Author(s): Ngatu, N.R.; Hirota, R., (15人2番目)
  • Journal Title: JAltemComplementMed Volume: 18 Issue: 1 Pages: 8-9
  • DOI: 10.1089/acm.2011.0696
  • Peer Reviewed
• [Journal Article] Anti-inflammatory effects of sacran, a novel polysaccharide from Aphanothece sacrum, on 2,4,6-trinitrochlorobenzene-induced allergic dermatitis in vivo (2012)
  • Author(s): Ngatu.NR
  • Journal Title: Ann.Allergy Asthma Immunol. Volume: Vol.108 Issue: 2 Pages: 117-122
  • DOI: 10.1016/j.anai.2011.10.013
  • Peer Reviewed
• [Journal Article] 環境衛生の面より考える思春期のアレルギー (2011)
  • Author(s): 中村裕之; 人見嘉哲; 神林康弘; 日比野由利; 柴田亜紀; 弘田量二; 福富友馬; 松崎一葉; 烏帽子田彰
  • Journal Title: 日本思春期学会 Volume: 29 Pages: 115-122
  • NAID: 10028178575
  • Peer Reviewed
• [Journal Article] Perception of the risk of sexual transmission of HIV among Congolese and Japanese university students (2011)
  • Author(s): Ngatu NR, Hirota R, Eitoku M, Muzembo BA, Nishimori M, Kuramochi M, Shintani S, Inoue S, Takiuchi R, Maegawa M, Ribble D, Mbenza MA, Situakibanza NTH, Mbanzulu PD, Suganuma N
  • Journal Title: Environmental Health and Preventive Medici ne Volume: 3 Issue: 2 Pages: 281-287
  • DOI: 10.1007/s12199-011-0232-z
  • NAID: 10030542967
  • Peer Reviewed
• [Journal Article] Practice of universal precautions and risk of occupational blood-borne viral infection among Congolese health care workers (2011)
  • Author(s): Ngatu NR, Phillips EK, Wembonyama SO, Hirota R, Kaunge NJ, Mbutshu LH, Perry J, Yoshikawa T, Jagger J, Suganuma N
  • Journal Title: American Journal of Infection Control Volume: 108 Issue: 1 Pages: 117-122
  • DOI: 10.1016/j.ajic.2011.01.021
  • Peer Reviewed
• [Journal Article] Assessment of lifestyle effect on oxidative stress biomarkers in free-living elderly in rural Japan (IF=1.782) (2011)
  • Author(s): Muzembo, B.A.; Narongpon, D.; Ngatu, N.R.; Eitoku, M.; Hirota, R.; Suganuma, N.
  • Journal Title: Geriatr Gerontol Int Volume: (Epub ahead of print) Issue: 3 Pages: 1-8
  • DOI: 10.1111/j.1447-0594.2011.00793.x
  • Peer Reviewed
• [Journal Article] Goishi Tea Consumption Inhibits Airway Hyperresponsiveness in BALB/ c Mice (2011)
  • Author(s): Hirota R, Ngatu NR, Miyamura M, Nakamura H, Suganuma N
  • Journal Title: BMC Immunology Volume: 12 Issue: 1 Pages: 45-45
  • DOI: 10.1186/1471-2172-12-45
  • Peer Reviewed
• [Journal Article] Meta-analysis of Acupuncture for Lumbago.(IF=no data) (2011)
  • Author(s): Hirota, R.; Oka, A.; Kuramoto, J.; Tanigawa, M.; Tsurunaga, G.; Nakamura, (9人中1人目)
  • Journal Title: J Prev.Med. Volume: 6 Pages: 133-138
  • Peer Reviewed
• [Journal Article] 環境衛生の面より考える思春期のアレルギー (2011)
  • Author(s): 中村裕之, 人見嘉哲, 神林康弘, 日比野由利, 柴田亜紀, 弘田量二, 福富友馬, 松崎一葉, 烏帽子田彰
  • Journal Title: 日本思春期学会誌 Volume: 29 Pages: 115-122
  • NAID: 10028178575
  • Peer Reviewed
• [Journal Article] Anti-inflammatory effects of limonene from yuzu (Citrus junos Tanaka) essential oil on eosinophils. (2010)
  • Author(s): R Hirota, NN Roger, H Nakamura, HS Song, M Sawamura, N Suganuma
  • Journal Title: J Food Sci Volume: 75 Pages: 87-92
  • Peer Reviewed
• [Journal Article] Nationwide Cross-Sectional Population-Based Study on the Prevalences of Asthma and Asthma Symptoms among Japanese Adults. (2010)
  • Author(s): Y Fukutomi, R Hirota (18番目21人)
  • Journal Title: Int Arch Allergy Immunol Volume: 153 Pages: 280-287
  • Peer Reviewed
• [Journal Article] 環境中化学物質によるアレルギー発症機序の解析 (2010)
  • Author(s): 中村裕之, 人見嘉哲, 弘田量二
  • Journal Title: アレルギーの臨床 Volume: 30 Pages: 917-920
  • Peer Reviewed
• [Presentation] Development of New Preventive method for Allergic Disease Using Filter Removing Environmental Chemicals (2012)
  • Author(s): R.Hirota; Dumavibhat, N.; Y.Kang; H.Nakamura; K.Sakurai; N.Suganuma
  • Organizer: 第30回国際保健医療学会西日本地方会
  • Place of Presentation: 高知大学(高知市)
  • Year and Date: 2012-03-03
• [Presentation] Development of New Preventive method for Allergic Disease Using Filter Removing Environmental Chemicals (2012)
  • Author(s): R.Hirota; Dumavibhat, N.; Y.Kang; H.Nakamura; K.Sakurai; N.Suganuma
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都大学(京都市)
• [Presentation] 南国土佐からやってきゆう、健康にえい、優れちゅう植物のはなし.マテリアルサイエンス研究科セミナー2011 (2011)
  • Author(s): 弘田量二
  • Organizer: 北陸先端大セミナー
  • Place of Presentation: 北陸先端大(石川県)(招待講演)
  • Year and Date: 2011-07-26
• [Presentation] Development of New Preventive method for Allergic Disease Using Filter Removing Environmental Chemicals (2011)
  • Author(s): R.Hirota; Dumavibhat, N.; Y.Kang; H.Nakamura; K.Sakurai; N.Suganuma
  • Organizer: 第55回中国四国合同産業衛生学会
  • Place of Presentation: 高知市あんしんセンター(高知市)
• [Presentation] Development of New Preventive method for Allergic Disease Using Filter Removing Environmental Chemicals. (2011)
  • Author(s): R.Hirota, N.Suganuma
  • Organizer: ACOH 2011
  • Place of Presentation: バンコク(タイ)
• [Presentation] アレルゲンで刺激されたマウスにおける多環式芳香族炭化水素類の気道過敏症増強作用と病理組織変化 (2010)
  • Author(s): 弘田量二, 菅沼成文
  • Organizer: 第8回予防医学会学術総会
  • Place of Presentation: 石川県立音楽堂交流ホール(石川県)
• [Remarks]
  • URL: http://www.kochi-ms.ac.jp/~ff_evrnm/html/staff_rh.html
• [Patent(Industrial Property Rights)] 多環芳香族炭化水素の除去方法 (2012)
  • Inventor(s): 弘田量二; Y.Kang; H.Nakamura; K.Sakurai; N.Suganuma
  • Industrial Property Rights Holder: 高知大学, ほか
  • Industrial Property Number: 2012-020278
  • Filing Date: 2012-02-02
• [Patent(Industrial Property Rights)] アトピー性皮膚炎の抗炎症作用物質 (2011)
  • Inventor(s): 弘田量二; Roger, N
  • Industrial Property Rights Holder: 高知大学
  • Filing Date: 2011-05-24
  • Overseas