| Project/Area Number |
22590554
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Nippon Medical School |
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Principal Investigator |
LI Qing 日本医科大学, 医学部, 准教授 (50250048)
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| Co-Investigator(Kenkyū-buntansha) |
KAWADA Tomoyuki 日本医科大学, 大学院医学研究科, 教授 (00224791)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 環境毒性学 / 免疫毒性学 / 農薬中毒 / アポトーシス / 抗癌タンパク / NK活性 / CTL活性 / LAK活性 / 免疫毒性 / カーバメイト系農薬 / Ziram / NK細胞 / T細胞 / Caspase / Cytochrome-C / ミトコンドリア / Perforin / Granzyme A / Granzyme B / Granzyme 3/K / Granulysin / NK (natural killer) / LAK (lymphokine-activated killer) / CTL (cytotoxic T lymphocyte) / ジラム |
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| Research Abstract |
Carbamate pesticides are widely used throughout the world in agriculture as fungicides and insecticides. Since carbamate pesticides contribute to chemical sensitivity and allergy related diseases; therefore, it is very important to investigate the immunotoxicity of carbamate pesticides and its mechanism in the perspecive of preventive medicine. In this study, we found that ziram, a carbamate fungicide, significantly inhibits natural killer (NK), lymphokine-activated killer (LAK) and cytotoxic T lymphocyte (CTL) activities. We have also found that ziram significantly induced apoptosis and necrosis in NK and T cells, and reduced the intracellular levels of anticancer proteins in NK cells, which contributed to the inhibitions of NK, LAK and CTL activities.
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