Analysis of the skin cancer induced by ultraviolet

• Project/Area Number: 22590558
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Chubu University
• Principal Investigator: YAMANOSHITA Osamu 中部大学, 生命健康科学部, 講師 (50424924)
• Co-Investigator(Kenkyū-buntansha): KATO Masashi 名古屋大学, 医学部, 教授 (10281073)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 皮膚ガン / 紫外線 / 悪性黒色腫 / 皮膚がん / 皮膚癌

Research Abstract

We analyzed the down-regulation gene with tumor progression in melanoma. UV radiation down-regulates expression of the gene in murine benign tumor. Down-regulation of the gene was observed with tumor progression in human melanoma. Expression of the gene in melanoma decreased cell growth and invasive ability. These results suggested that the gene may prevent progression of melanoma.

Research Products

• [Journal Article] Enhanced carcinogenicity by coexposure to arsenic and iron and a novel remediation system for the elements in well drinking water. (2013)
  • Author(s): Kumasaka YM, et al.
  • Journal Title: Arch Toxicol. Volume: 87 Issue: 3 Pages: 439-447
  • DOI: 10.1007/s00204-012-0964-6
  • Peer Reviewed
• [Journal Article] RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy. (2012)
  • Author(s): Ya manoshita O Kato M
  • Journal Title: Dermatol Res Pract. Volume: 2012 Pages: 354191-354191
  • DOI: 10.1155/2012/354191
  • Peer Reviewed
• [Journal Article] Molecular Network Associated with MITF in Skin Melanoma Development and Progression. (2011)
  • Author(s): Ya manoshita O Kato M
  • Journal Title: J Skin Cancer. Volume: 2011 Pages: 730170-730170
  • DOI: 10.1155/2011/730170
  • Peer Reviewed
• [Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation. (2010)
  • Author(s): Kato M.
  • Journal Title: J Cell Biochem Volume: 110 Pages: 399-407
  • Peer Reviewed
• [Presentation] 悪性黒色腫におけるNKX3.1遺伝子変異の解析 (2013)
  • Author(s): 山ノ下 理
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢市
  • Year and Date: 2013-03-25
• [Presentation] 悪性黒色腫におけるNKX3.1遺伝子変異の解析
  • Author(s): 山ノ下 理
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢大学（石川県）