Research about the damage of lung exposed by Asian sand dust.

• Project/Area Number: 22590559
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Suzuka University of Medical Science
• Principal Investigator: INOUE Sumiko 鈴鹿医療科学大学, 薬学部, 准教授 (20378657)
• Co-Investigator(Renkei-kenkyūsha): HIRAKU Yuusuke (30324510) ; KAWANISHI Shousuke (10025637)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 黄砂 / 肺細胞 / ICR マウス / 炎症 / 8-ニトログアニン / 8-oxodG / 酸化的損傷 / プロテオミクス / OVA / SiO_2 / 肺 / 8-nitroguanine / プロテオーム / ICRマウス / Al_2O_3

Research Abstract

The potential pulmonary toxicity by Asian sand dust was investigated. ICR mice were given suspended Asian sand dust with saline by intranasal droplet application once/a week, totally 4 times. Histologically examined lungs showed inflammation by Asian sand dust and association of oxidative stress. Quantitative study by HPLC showed 8-oxodG in lung of mice exposed by Asian sand dust increased significantly. These results suggest that Asian sand dust induces the formation of oxidative species in the lung and leads to inflammation.

Research Products

• [Journal Article] Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis. (2012)
  • Author(s): Murata M, Thanan R, Ma N, Kawanishi S.
  • Journal Title: J Biomed Biotechnol. Volume: 2012 Pages: 623019-623019
• [Journal Article] 家族性脳動静脈奇形と遺伝子 (2011)
  • Author(s): 小泉昭夫、井上純子
  • Journal Title: Clinical Neuroscience2 Volume: 9 Pages: 1147-1150
• [Journal Article] 家族性脳動静脈奇形と遺伝子 (2011)
  • Author(s): 小泉昭夫、井上純子
  • Journal Title: Clinical Neuroscience(月刊臨床神経科学) Volume: Vol.29 Pages: 1151-1153
• [Journal Article] The role of iNOS-mediated DNA damage in infection- and asbestos-induced carcinogenesis (2010)
  • Author(s): Hiraku Y, Kawanishi S, Ichinose T,Murata,M
  • Journal Title: Ann. NY Acad. Sci. Volume: 1203 Pages: 15-22
• [Journal Article] Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance (2010)
  • Author(s): Hiraku, Y.
  • Journal Title: Environ. Health Prev. Med. Volume: 15 Pages: 63-72
  • NAID: 10026959928
• [Book] 8-Nitroguanine: A potential biomarker to evaluate the risk of inflammation-related carcinogenesis. In: Biomarker (2012)
  • Author(s): Ma N, Murata M, Ohnishi S, Thanan R, Hiraku Y, Kawanishi S.
  • Publisher: Khan TK (ed.). InTech
• [Book] Prognostic significance of nitrative DNA damage in infection- and inflammation-related carcinogenesis, In: Nitric Oxide and Cancer: Prognosis, Prevention and Therapy (2010)
  • Author(s): Hiraku, Y., Kawanishi, S.
  • Publisher: Springer, New York, NY, USA