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Research about the damage of lung exposed by Asian sand dust.

Research Project

Project/Area Number 22590559
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionSuzuka University of Medical Science

Principal Investigator

INOUE Sumiko  鈴鹿医療科学大学, 薬学部, 准教授 (20378657)

Co-Investigator(Renkei-kenkyūsha) HIRAKU Yuusuke   (30324510)
KAWANISHI Shousuke   (10025637)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords黄砂 / 肺細胞 / ICR マウス / 炎症 / 8-ニトログアニン / 8-oxodG / 酸化的損傷 / プロテオミクス / OVA / SiO_2 / 肺 / 8-nitroguanine / プロテオーム / ICRマウス / Al_2O_3
Research Abstract

The potential pulmonary toxicity by Asian sand dust was investigated. ICR mice were given suspended Asian sand dust with saline by intranasal droplet application once/a week, totally 4 times. Histologically examined lungs showed inflammation by Asian sand dust and association of oxidative stress. Quantitative study by HPLC showed 8-oxodG in lung of mice exposed by Asian sand dust increased significantly. These results suggest that Asian sand dust induces the formation of oxidative species in the lung and leads to inflammation.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2012 2011 2010

All Journal Article (5 results) Book (2 results)

  • [Journal Article] Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis.2012

    • Author(s)
      Murata M, Thanan R, Ma N, Kawanishi S.
    • Journal Title

      J Biomed Biotechnol.

      Volume: 2012 Pages: 623019-623019

    • Related Report
      2012 Final Research Report
  • [Journal Article] 家族性脳動静脈奇形と遺伝子2011

    • Author(s)
      小泉昭夫、井上純子
    • Journal Title

      Clinical Neuroscience2

      Volume: 9 Pages: 1147-1150

    • Related Report
      2012 Final Research Report
  • [Journal Article] 家族性脳動静脈奇形と遺伝子2011

    • Author(s)
      小泉昭夫、井上純子
    • Journal Title

      Clinical Neuroscience(月刊臨床神経科学)

      Volume: Vol.29 Pages: 1151-1153

    • Related Report
      2011 Annual Research Report
  • [Journal Article] The role of iNOS-mediated DNA damage in infection- and asbestos-induced carcinogenesis2010

    • Author(s)
      Hiraku Y, Kawanishi S, Ichinose T,Murata,M
    • Journal Title

      Ann. NY Acad. Sci.

      Volume: 1203 Pages: 15-22

    • Related Report
      2012 Final Research Report
  • [Journal Article] Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance2010

    • Author(s)
      Hiraku, Y.
    • Journal Title

      Environ. Health Prev. Med.

      Volume: 15 Pages: 63-72

    • NAID

      10026959928

    • Related Report
      2012 Final Research Report
  • [Book] 8-Nitroguanine: A potential biomarker to evaluate the risk of inflammation-related carcinogenesis. In: Biomarker2012

    • Author(s)
      Ma N, Murata M, Ohnishi S, Thanan R, Hiraku Y, Kawanishi S.
    • Publisher
      Khan TK (ed.). InTech
    • Related Report
      2012 Final Research Report
  • [Book] Prognostic significance of nitrative DNA damage in infection- and inflammation-related carcinogenesis, In: Nitric Oxide and Cancer: Prognosis, Prevention and Therapy2010

    • Author(s)
      Hiraku, Y., Kawanishi, S.
    • Publisher
      Springer, New York, NY, USA
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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