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Persistent on-going myocardial necrosis in general population

Research Project

Project/Area Number 22590564
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKurume University

Principal Investigator

NIIYAMA Hiroshi  久留米大学, 医学部, 助教 (30309778)

Co-Investigator(Kenkyū-buntansha) ANEGAWA Takahiro  久留米大学, 医学部, 助教 (00511833)
YASUOKA Suguru  久留米大学, 医学部, 助教 (10461435)
ADACHI Hisashi  久留米大学, 医学部, 教授 (40212518)
KAJIMOTO Hidemi  久留米大学, 循環器病研究所, 助教 (50349700)
KAI Hisashi  久留米大学, 医学部, 准教授 (60281531)
TAKEMIYA Kiyoko  久留米大学, 医学部, 助教 (20535075)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords予防医学 / 心筋障害 / 心不全 / 心血管障害 / マーカー
Research Abstract

Circulating high-sensitivity cardiac troponin T (hsTnT) levels are highlighted as a biomarker reflecting persistent, on-going myocardial damages. We sought to examine the correlation between hsTnT levels and conventional cardiovascular risk factors and surrogate markers for cardiovascular events in healthy general subjects who were registered in the Tanushimaru study. hsTnT was detected (the cut-off level: >0.003 ng/mL) in approximately 40% of 2,100 healthy subjects. Univariate analysis reveled that age, estimated glomerular filtration rate (eGFR)(inversely), hypertension, intima-media thickness, and serum uric acid were significantly associated with hsTnT levels. Multiple regression analysis showed that only age was a significant determinant factor for hsTnT levels (p<0.001). Next, we examined the correlation between the incidence of atrial fibrillation (AF) and hsTnT levels in healthy general subjects in Uku study. Multiple regression analysis revealed that eGFR (p<0.001) and sTnT levels (p=0.012) were significant determinant factor for AF. Adjusted hsTnT levels were significantly greater in the subjects with AF than in the non-AF subjects (p=0.015). Moreover, the incidence of AF was positively associated with the quartile stratified by increasing hsTnT levels (p=0.003).

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2013 2012 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results)

  • [Journal Article] Embryonic stem cell-derived endothelial cells engraft into the ischemic hindlimb and restore perfusion.2010

    • Author(s)
      Huang NF, Niiyama H
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 30 Pages: 984-991

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Candesartan-based Treatment for Variability Lowering of Individual Blood Pressure and Heart Rate at Home Study: CAVALIERat HOME.2013

    • Author(s)
      Kai H
    • Organizer
      日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Candesartan-based Treatment for Variability Lowering of Individual Blood Pressure and Heart Rate at Home Study: CAVALIER at HOME2013

    • Author(s)
      Hisashi Kai
    • Organizer
      日本循環器学会学術集会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 非弁膜性心房細動を有する脳梗塞患者からみたCHADS2スコア、CHA2DS2-VAScスコア.2012

    • Author(s)
      姉川敬裕、甲斐久史、梶本英美
    • Organizer
      日本心臓病学会学術集会
    • Place of Presentation
      金沢
    • Related Report
      2012 Final Research Report
  • [Presentation] 非弁膜性心房細動を有する脳梗塞患者からみたCHADS2スコア、CHA2DS2-VAScスコア2012

    • Author(s)
      姉川敬裕
    • Organizer
      日本心臓病学会学術集会
    • Place of Presentation
      金沢市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Low diastolic blood pressure is not an independent risk for cardiovascular death in revascularized coronary artery disease patients2011

    • Author(s)
      Kai H, Niiyama H, 他5名5番目
    • Organizer
      European Society of Cardiology Congress 2011
    • Place of Presentation
      Paris, France
    • Related Report
      2011 Annual Research Report
  • [Presentation] Low diastolic blood pressure is not an independent risk for cardiovascular death inrevascularized coronary artery disease patients.2010

    • Author(s)
      Kai H, Niiyama H
    • Place of Presentation
      Paris, France
    • Related Report
      2012 Final Research Report
  • [Presentation] Increased circulating asymmetricdimethylarginine in chronic kidney disease mice induces endothelial dysfunction by inhibiting Ca/Calmodulin-dependent protein kinase II-eNOS signaling.2010

    • Author(s)
      Kajimoto H, Kai H
    • Organizer
      American Heart Association Scietific Meeting2010
    • Place of Presentation
      Chicago, IL, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Eplerenone prevented the large blood pressurevariability-induced aggravation of cardiac remodeling by inhibiting of perivascular inflammation in spontaneously hypertensive rats.2010

    • Author(s)
      Yasuoka S, Kai
    • Organizer
      European Society of CardiologyCongress 2010
    • Place of Presentation
      Stockholm , Sweden
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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