Pulmonary effect of titanium dioxide and various particles by instillation to rats: in relation with surface area dose metrics.
| Project/Area Number |
22590566
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
OGAMI Akira 産業医科大学, 産業生態科学研究所, 教授 (40301692)
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| Co-Investigator(Kenkyū-buntansha) |
MYOJO Toshihiko 産業医科大学, 産業生態科学研究所, 教授 (00209959)
橋場 昌義 産業医科大学, 産業生態科学研究所, 専門修練医 (90566431)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ナノ粒子 / 気管内注入 / 肺毒性 / 二酸化チタン / 表面積 / ラット / 気管内注入試験 |
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| Research Abstract |
We evaluated the pulmonary effect of nano-titanium dioxide in relation with surface area. We used five nano-titanium dioxide particles from different products. Each material suspension at the dose of lmg Per rat was intratracheally instilled once to maleWistar rats. Pathological results showed that, with the similar surface area, the difference of pulmonary effect was observed by the product of nano-titanium dioxide. Surface area should be one of a significant factor for toxicity of nanoparticles. However, other factors such as manufacturing method or surface characters of particles may be also responsible for the toxicity.
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Report
(4 results)
Research Products
(8 results)
