| Project/Area Number |
22590568
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Louis Pasteur Center For Medical Research |
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Principal Investigator |
UCHIYAMA Iwao 財団法人ルイ・パストゥール医学研究センター, 上席研究員 (20151897)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Toshikazu 京都府立医科大学, 学長 (60128725)
TAKANO Hirohisa 京都大学, 大学院・工学研究科, 教授 (60281698)
TANIGAWA Mari 財団法人ルイ・パストゥール医学研究センター, 臨床免疫機能研究室, 室長 (50291018)
AZUMA Kenichi 近畿大学, 医学部, 講師 (80469246)
MURAYAMA Rumiko 京都大学, 大学院・工学研究科, 助教 (20280761)
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| Research Collaborator |
AZUMA Michiyo 畿央大学, 健康科学部, 准教授 (10314527)
BANBA Ikuko 近畿大学, 医学部, 助教 (20465470)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 化学物質過敏症 / シックハウス / ストレス / 免疫学 / 環境 |
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| Research Abstract |
We investigated indoor environmental quality, immunological status, and response to olfactory stimulus regarding patients with Multiple Chemical Sensitivity (MCS) in Hyakumanben clinic “Sick house outpatient”. MCS patients lived at very clean indoor environmental spaces in their houses. The immunological status of MCS is not Th2 dominant and different from allergy. Prefrontal cortex (PFC) area of MCS patients activated by olfactory stimuli. The excess responses of PFC to odorous substances, specific changes of immune system were indicated as characteristics of MCS.
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