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Relationship between age-dependent decline in cognitive function and lifestyle-related disease risks in a healthy adult population

Research Project

Project/Area Number 22590583
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionNagoya University

Principal Investigator

KONDO Takaaki  名古屋大学, 医学系研究科(保健), 教授 (00195900)

Co-Investigator(Renkei-kenkyūsha) ITO Emi  名古屋大学, 医学系研究科(保健), 講師 (00314021)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords生活習慣病 / 高次脳機能 / 脂肪酸 / 血管内皮中膜肥厚 / 酸化ストレス / 認知機能 / 血管内皮機能 / 前頭葉機能
Research Abstract

We performed an epidemiological study to explore the relationship between such cognitive functions as memory or attention and various biomarkers. Our subjects were 505 (210 males and 295 females) annual health checkup participants aged 40 or more. Particularly focused in this study was the relationship of serum fatty acid composition (%) and cognitive function. Results indicated that clupanodonic acid and DHA has a statistically significant and borderline significant association, respectively, with low attention only in females, but EPA showed no such associations. Males failed to show any relationships between fatty acid composition and cognitive function.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (40 results)

All 2012 2011 2010 Other

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (17 results) Remarks (1 results)

  • [Journal Article] Prevalence of Helicobacter Pylori infection measured with urinary antibody in an urban area of Japan, 2008-20102012

    • Author(s)
      Tamura T, Morita E, Kondo T, Ueyama J, Tanaka T, Kida Y, Hori Y, Inoue S, Tomita K, Okada R, Kawai S, Hishida A, Naito M, Wakai K, Hamajima N
    • Journal Title

      Nagoya J Med Sci

      Volume: 74 Pages: 63-70

    • NAID

      120003837118

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preventive medical services uncovered by public health insurance at Daiko Medical Center in Japan, 2004-20112012

    • Author(s)
      Tamura T, Kurata M, Kondo T, Goto Y, Kamiya Y, Kawai S, Mitsuda Y, Hamajima N
    • Journal Title

      Nagoya J Med Sci

      Volume: 74 Pages: 115-121

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Urinary concentrations of organophosphorus insecticide metabolites in Japanese workers2012

    • Author(s)
      Ueyama J, Saito I, Kondo T, Taki T, Kimata A, Saito S, Ito Y, Murata K, Iwata T, Goto M, Shibata E, Wakusawa S, Kamijima M
    • Journal Title

      Chemosphere

      Volume: 87 Pages: 1403-1409

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 女性家族介護者の筋骨格系症状に関連する生活習慣要因2012

    • Author(s)
      鈴木岸子, 玉腰浩司, 星野純子, 塚本早苗, 近藤高明, 榊原久孝, 堀容子
    • Journal Title

      日本看護医療学会雑誌

      Volume: 14 Pages: 13-22

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of hypertension-related factors in female home caregivers in Japan - Comparison with general community non-caregivers2012

    • Author(s)
      星野 純子
    • Journal Title

      Journal of Clinical Nursing

      Volume: 22 Issue: 3-4 Pages: 466-478

    • DOI

      10.1111/j.1365-2702.2011.04039.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of light smoking on extra-high-frequency auditory thresholds in young adults.2011

    • Author(s)
      Ohgami N, Kondo T, Kato, M
    • Journal Title

      Toxicol Ind Health

      Volume: 27 Pages: 143-147

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of UGT1A1 Gly71Arg with urine urobilinogen2011

    • Author(s)
      Kataoka R, Kimata A, Yamamoto K, Hirosawa N, Ueyama J, Kondo T, Okada R, Kawai S, Hishida A, Naito M, Morita E, Wakai K, Hamajima N
    • Journal Title

      Nagoya J Med Sci

      Volume: 73 Pages: 33-40

    • NAID

      120003043298

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement in Helicobacter pylori eradication rate through CYP2C19 genotyping at a clinic2011

    • Author(s)
      Tamura T, Kurata M, Inoue S, Kondo T, Goto Y, Kamiya Y, Kawai S, Hamajima N
    • Journal Title

      Nagoya J Med Sci

      Volume: 73 Pages: 25-31

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lifestyle characteristics of dietary supplement users from a Japanese civil servant population2011

    • Author(s)
      Kondo T, Ueyama S
    • Journal Title

      Bull Soc Med

      Volume: 28 Pages: 57-64

    • NAID

      10028256855

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 介護と高血圧との関連:横断調査による検討2011

    • Author(s)
      星野純子, 堀容子, 近藤高明, 玉腰浩司, 大西丈二, 豊嶋英明, 榊原久孝
    • Journal Title

      日本循環器病予防学雑誌

      Volume: 48 Pages: 180-190

    • NAID

      10029555522

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sunlight exposure-mediated DNA damage in young adults2011

    • Author(s)
      Kato M, Iida M, Goto Y, Kondo T, Yajima I
    • Journal Title

      Cancer Epidemiol Biomarkers Prev

      Volume: 20 Pages: 1622-1628

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Study profile on baseline survey of Daiko Study in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study)2011

    • Author(s)
      Morita E, Hamajima N, Hishida A, Aoyama K, Okada R, Kawai S, Tomita K, Kuriki S, Tamura T, Naito M, Kondo T, Ueyama J, Kimata A, Yamamoto K, Hori Y, Hoshino J, Hamamoto R, Tsukamoto S, Onishi J, Hagikura S, Naito H, Hibi S, Ito Y, Wakai K
    • Journal Title

      Nagoya J Med Sci

      Volume: 73 Pages: 187-195

    • NAID

      120003277478

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 女性における家族介護者の高血圧自覚の有無による血圧管理状況.2011

    • Author(s)
      鈴木洋子, 堀容子, 星野純子, 濱本律子, 杉山晃子, 岡田武, 永井邦芳, 近藤高明, 玉腰浩司, 岡本和士, 長澤伸江, 豊嶋英明, 榊原久孝
    • Journal Title

      日本公衆衛生学会雑誌

      Volume: 58 Pages: 1016-1025

    • NAID

      10030270256

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Study profile on baseline survey of Daiko Study in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study)2011

    • Author(s)
      森田えみ
    • Journal Title

      Nagoya Journal of Medical Science

      Volume: 73 Pages: 187-195

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of DDVP on urinary excretion levels of pyrethroid metabolite 3-phenoxybenzoic acid in rats2011

    • Author(s)
      広澤奈緒子
    • Journal Title

      Toxicology Letter

      Volume: 203 Issue: 1 Pages: 28-32

    • DOI

      10.1016/j.toxlet.2011.02.016

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lifestyle characteristics of dietary supplement users from a Japanese civil servant population2011

    • Author(s)
      近藤高明
    • Journal Title

      Bulletin of Social Medicine

      Volume: 28 Pages: 57-64

    • NAID

      10028256855

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Body mass index and all-cause mortality among Japanese older adults: findings from the Japan Collaborative Cohort Study2010

    • Author(s)
      Tamakoshi A, Yatsuya H, Lin Y, Tamakoshi K, Kondo T, Suzuki S, Yagyu K, Kikuchi S for the JACC Study Group.
    • Journal Title

      Obesity

      Volume: 18 Pages: 362-369

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations of plasma IL-8 levels with Helicobacter pylori seropositivity, gastric atrophy, and IL-8 T251A genotypes2010

    • Author(s)
      Naito M, Eguchi H, Goto Y, Kondo T, Nishio K, Ishida, Kawai S, Okada R, Hishida A, Wakai K, Hamajima N
    • Journal Title

      Epidemiol Infect

      Volume: 138 Pages: 512-518

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] β-Glucuronidase activity is a sensitive biomarker to assess low-level organophosphorus insecticide exposure2010

    • Author(s)
      Ueyama J, Satoh T, Kondo T, Takagi K, Shibata E, Goto M, Kimata A, Saito I, Hasegawa T, Wakusawa S, Kamijima M
    • Journal Title

      Toxicol Lett

      Volume: 193 Pages: 115-119

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Revised method for routine determination of urinary dialkyl phosphates using gas chromatography-mass spectrometry2010

    • Author(s)
      Ueyama J, Kamijima M, Kondo T, Takagi K, Shibata E, Hasegawa T, Wakusawa S, Taki T, Gotoh M, Saito I
    • Journal Title

      J Chromatogr B

      Volume: 878 Pages: 1257-1263

    • NAID

      10028035703

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 地域単位のソーシャル・キャピタルの測定尺度の妥当性に関する検討 エコ・メトリックな環境測定を行う「近隣効果尺度」と地域の健康2010

    • Author(s)
      大賀英史, 大森豊緑, 近藤高明, 小山修
    • Journal Title

      厚生の指標

      Volume: 57 Pages: 32-39

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Revised method for routine determination of urinary dialkyl phosphates using gas chromatography-mass spectrometry2010

    • Author(s)
      Ueyama Jun
    • Journal Title

      Journal of Chromatography B

      Volume: 878 Pages: 1257-1263

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 日本多施設共同コーホート研究に参加した家族介護者における心身の健康状態2012

    • Author(s)
      岡村雪子, 玉腰浩司, 星野純子, 森祥子, 近藤高明, 榊原久孝, 塚本早苗, 牧野史子, 濱田有希, 徳永嶺, 堀容子
    • Organizer
      第14回日本看護医療学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-08
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト集団におけるドコサヘキサエン酸(DHA)摂取と血漿、赤血球膜組織リン脂質の脂肪酸構成との関連2012

    • Author(s)
      渡邉美貴, 立石多貴子, 松尾恵太郎, 細野覚代, 尾瀬功, 加藤久登, 田中英夫, 近藤高明
    • Organizer
      第58回東海公衆衛生学会学術大会
    • Place of Presentation
      津
    • Year and Date
      2012-07-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 健常成人集団での血清脂肪酸構成とカロテノイドとの関連2012

    • Author(s)
      井村陽介, 近藤高明, 田中哲也, 喜田優人, 上山純, 冨岡沙紀, 長谷川直美, 深見明希, 鈴木康司, 井上孝, 伊藤宜則, 浜島信之
    • Organizer
      第58回東海公衆衛生学会学術大会
    • Place of Presentation
      津
    • Year and Date
      2012-07-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 健常成人集団での血清脂肪酸構成と動脈硬化指標との関連2012

    • Author(s)
      近藤高明, 田中哲也, 喜田優人, 井村陽介, 上山純, 冨岡沙紀, 長谷川直美, 深見明希, 市野直浩, 刑部恵介, 杉本恵子, 鈴木康司, 井上孝, 伊藤宜則, 浜島信之
    • Organizer
      第58回東海公衆衛生学会学術大会
    • Place of Presentation
      津
    • Year and Date
      2012-07-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 血清脂肪酸(FA)とFA摂取量およびメタボリックシンドローム(MetS)リスク2012

    • Author(s)
      田中哲也, 近藤高明, 喜田優人, 上山純, 鈴木康司, 井上孝, 伊藤宜則, 若井建志, 浜島信之
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 血清脂肪酸(FA)とFA摂取量およびメタボリックシンドローム(MetS)リスク2012

    • Author(s)
      田中哲也
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都大学(京都府)
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 健常成人集団での血清脂肪酸構成と動脈硬化指標との関連2012

    • Author(s)
      近藤 高明
    • Organizer
      第58回東海公衆衛生学会学術大会
    • Place of Presentation
      三重県立看護大学(三重県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 健常成人集団での血清脂肪酸構成とカロテノイドとの関連2012

    • Author(s)
      井村 陽介
    • Organizer
      第58回東海公衆衛生学会学術大会
    • Place of Presentation
      三重県立看護大学(三重県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト集団におけるドコサヘキサエン酸(DHA)摂取と血漿、赤血球膜組織リン脂質の脂肪酸構成との関連2012

    • Author(s)
      渡邉 美貴
    • Organizer
      第58回東海公衆衛生学会学術大会
    • Place of Presentation
      三重県立看護大学(三重県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 健常成人集団での血清脂肪酸構成と低度炎症マーカーとの関連2011

    • Author(s)
      近藤高明, 田中哲也, 喜田優人, 井村陽介, 冨岡沙紀, 長谷川直美, 深見明希, 上山純, 鈴木康司, 井上孝, 伊藤宜則, 浜島信之
    • Organizer
      第57回東海公衆衛生学会学術大会
    • Place of Presentation
      大府
    • Year and Date
      2011-07-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 健常成人集団における血清脂肪酸構成割合と食習慣およびmetabolic syndrome(MetS)との関連2011

    • Author(s)
      田中哲也, 近藤高明, 喜田優人, 井村陽介, 冨岡沙紀, 長谷川直美, 深見明希, 上山純, 鈴木康司, 井上孝, 伊藤宜則, 若井建志, 浜島信之
    • Organizer
      第57回東海公衆衛生学会学術大会
    • Place of Presentation
      大府
    • Year and Date
      2011-07-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 健常成人集団での血清脂肪酸構成と低度炎症マーカーとの関連2011

    • Author(s)
      近藤高明
    • Organizer
      第57回東海公衆衛生学会学術大会
    • Place of Presentation
      愛知健康の森(愛知県)
    • Year and Date
      2011-07-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 一般健常集団における血清中脂肪酸とメタボリックシンドローム診断項目との関連2011

    • Author(s)
      田中哲也, 近藤高明, 喜田優人, 上山純, 浜島信之, 鈴木康司, 井上孝, 倉岡光穂, 王音倩, 蓮井恵子
    • Organizer
      第81回日本衛生学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 問診票による身体活動量推定量と血圧や血清生化学検査値との関連2011

    • Author(s)
      近藤高明, 加藤千秋, 喜田優人, 田中哲也, 上山純
    • Organizer
      第81回日本衛生学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 健常成人集団での血清carotenoid値とmetabolic syndrome診断項目集積数との関連2010

    • Author(s)
      田中哲也, 近藤高明, 喜田優人, 一ノ谷英憲, 山本佳那実, 鈴木麻予, 服部由花, 木全明子, 上山純
    • Organizer
      第56回東海公衆衛生学会学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-07-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 非喫煙成人女性での尿中コチニン値と受動喫煙との関連2010

    • Author(s)
      喜田優人, 近藤高明, 田中哲也, 中川優子, 木下香織, 鈴木麻予, 服部由花, 一ノ谷英憲, 倉岡光穂, 木全明子, 上山純, 森田えみ, 田村高志, 栗木砂家加, 冨田耕太郎, 岡田理恵子, 川合紗世, 菱田朝陽, 内藤真理子, 若井建志, 浜島信之
    • Organizer
      第56回東海公衆衛生学会学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-07-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 日本多施設共同コーホート研究(J-MICC Study)大幸研究ベースライン調査の概要2010

    • Author(s)
      森田えみ, 若井建志, 栗木砂家加, 冨田耕太郎, 田村高志, 青山京子, 伊藤宜則, 岡田理恵子, 川合紗世, 菱田朝陽, 内藤真理子, 浜島信之, 大西丈二, 堀容子, 塚本早苗, 濱本律子, 杉山晃子, 近藤高明, 上山純, 木全明子, 山本佳那実, 廣澤奈緒子, 一ノ谷英憲, 喜田優人, 田中哲也
    • Organizer
      第17回日本がん予防学会
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-15
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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