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Significance of impaired glucose tolerance as the risk factor ofmalignant neoplasms and cardiovascular disease: A cohort study

Research Project

Project/Area Number 22590592
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionSapporo Medical University

Principal Investigator

SAITOH Shigeyuki  札幌医科大学, 保健医療学部, 教授 (60253994)

Co-Investigator(Kenkyū-buntansha) OHNISHI Hirohumi  札幌医科大学, 医学部, 准教授 (20359996)
SHIMAMOTO Kazuaki  札幌医科大学, 学長 (40136940)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords耐糖能異常 / 心血管疾患 / 悪性新生物 / 疫学 / 生活習慣病 / 動脈硬化 / 危険因子
Research Abstract

By means of a cohort study, we evaluated the association between impaired glucose tolerance(IGT)and the occurrence of malignant neoplasms (NEO) and cardiovascular diseases(CVD). In 1986 ・ 1987, inhabitants of 1,989 people were randomly selected and followed for 23.5 years, and the onset and death of both NEOand CVD were registered over this period. As a result, we observed the risk of the NEO and CVD become 2.16 and 2.05, respectively , in comparison with non-IGT in IGT. IGTwas a common risk factor of both NEO and CVD, and the possibility that the management of IGT contributed to the prevention of NEO and CVD in the same way.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2012 2011 2010

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (4 results)

  • [Journal Article] Effects of hypertension on longitudinal trends in blood pressure and plasma metabolic profile: Mixed-effects model analysis2012

    • Author(s)
      Misumata K, Saitoh S, Akasaka H, Mitsumata K, Ohnishi H, Akasaka H, Miura T
    • Journal Title

      Hypertens

      Volume: 60 Pages: 1124-1130

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Atherogenic lipid profiles relates to postprandial hyperglycemia and hyperinsulinemia due to whole body insulin resistance in prediabetic subjects2012

    • Author(s)
      Miyazaki Y, Furugen M, Akasaka H,Saitoh S, Mitsumata K, Miura T
    • Journal Title

      J Diabetes Mellitus

      Volume: 3 Pages: 272-278

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Matsuda-DeFronzo insulin sensitivity index is a better predictor than HOMA-IR of hypertension in Japanese: the Tanno-Sobetsu study2012

    • Author(s)
      Furugen M, Saitoh S, Ohnishi H, Akasaka H, Mitsumata K, Chiba M, Furukawa T, Miyazaki Y, Shimamoto K, Miura T
    • Journal Title

      J Hum Hypertens

      Volume: 26 Pages: 325-333

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration2012

    • Author(s)
      Oguro R, Kamide K, Katsuya T, Akasaka H, Congrains A, Arai Y, Hirose N, Saitoh S, Ohishi M, Miura T, Rakugi H
    • Journal Title

      Exp Gerontol

      Volume: 47 Pages: 183-187

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 地域一般住民高齢者・非高齢者における腹部肥満の糖尿病発症リスクに関する検討-端舒・壮瞥町研究-2011

    • Author(s)
      藤井瑞恵, 大西浩文, 斎藤重幸, 他
    • Journal Title

      日老医誌

      Volume: 48 Pages: 71-77

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Matsuda-DeFronzo insulin sensitivity index is a better predictor than HOMA-IR of hypertension in Japanese : the Tanno-Sobetsu study2011

    • Author(s)
      M Furugen, S Saitoh, H Ohnishi, H, et al
    • Journal Title

      Journal of Human Hypertension

      Volume: 17 Pages: 11-19

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 地域一般住民高齢者・非高齢者における腹部肥満の糖尿病発症リスクに関する検討-端野・壮瞥町研究-2011

    • Author(s)
      藤井瑞恵, 大西浩文, 斎藤重幸, 他
    • Journal Title

      日老医誌

      Volume: 48 Pages: 71-77

    • NAID

      10030469085

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations of metabolic factors, especially serum retinolbinding protein 4 (RBP4), with blood pressure in Japanese2010

    • Author(s)
      Chiba M, Saitoh S, et al
    • Journal Title

      Endocrine Journal

      Volume: 57 Pages: 811-817

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 地域一般住民における ALT、γ-GPT の組み合わせによる新規糖尿病の発症予測に関する検討2011

    • Author(s)
      大西浩文、斎藤重幸
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] 糖尿病が心血管病死亡に与える影響2011

    • Author(s)
      平川洋一郎、土井康文、清原裕、 斎藤重幸
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] Epidemiologic studies of Diabetes and Atherosclerotic Diseases in Japan and the evidence of cardiovascular disease prevention in patients with diabetes2011

    • Author(s)
      Saitoh S
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] Epidemiological aspects of diabetes and metabolic syndrome in Japanese general population2010

    • Author(s)
      Saitoh S
    • Organizer
      14^<th> International Congress of Endcrinology
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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