| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
To clarify epidemics of Norovirus infection, we examined genetic and antigenetic diversity of Norovirus GII.2 and GII.6 strains periodically detected in Osaka city Japan using the VLPs. Although each variant GII.2 strains possessed different antigenicity, did not change the hist-blood group antigen(HBGA) binding ability. These GII.2 variant strains were considered as neutralize escape mutant. Norovirus GII.6 strains werefurther classified into 3 genetic clusters, and the HBGA binding ability and the antigenicity differed each other. The periodically epidemics of Norovirus GII.6 strains were occurred by at least 3 different variants.
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