| Project/Area Number |
22590599
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | University of Nagasaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKU Tsuneyuki 長崎県立大学, 看護栄養学部, 名誉教授 (50010096)
OMAGARI Katsuhisa 長崎県立大学, 看護栄養学部, 教授 (90244045)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | プレバイオティクス / 水素ガス / 下痢抑制作用 / 難消化性糖質 / 腸内細菌 |
|---|
| Research Abstract |
Non-pathogenic diarrhea is often induced by the enteral nutrition and antibiotic treatment. We have already clarified that the induction of osmotic diarrhea was suppressed by the ingestion of nondigestible oligosaccharide. In this study we examined the interaction among the suppression to diarrhea and the change in intestinal microflora by the ingestion of fructooligosaccharide using modeled animals that induce the diarrhea. It was suggested that the suppression for diarrhea interacted among the higher excretion of hydrogen gas, the better levels of oxidative stress markers, inflammatory cytokines, and lower activities of harmful enzymes derived from intestinal microbes. We believe that the nondigestible saccharides can contribute the improvement of the liquid formula.
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