| Project/Area Number |
22590601
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
SAKATA Kiyomi 岩手医科大学, 医学部衛生学公衆衛生学講座, 教授 (50225794)
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| Co-Investigator(Kenkyū-buntansha) |
HITOMI Jiro 岩手医科大学, 医学部, 教授 (00218728)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | バイオマーカー / アテローム血栓症 / 動脈硬化 / 診断薬 / コホート研究 / 脳卒中 / 心筋梗塞 / 危険因子 |
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| Research Abstract |
Utilizing 468 preserved serums used for cohort studies whose initial follow-up was more than 6 years ago, serum levels of S100A12 protein and breakdown product of complement component C3a were measured, and comparison with their baseline results was made.Spearman’s coefficient of correlation of the serum concentration between S100A12 and C3a was 0.504 with p-value ≦ 0.0001. The correlation coefficients of S100A12 concentration with the level of triglyceride and that with leukocyte counts were significant. The correlation coefficients of the concentration of the breakdown product of C3a with HDL cholesterol level, leukocyte counts, blood sugar level, HbAlc, systolic blood pressure, diastolic blood pressure, and Body Mass Index were also significant. Neither existing condition nor incident stroke had significant association with S100A12 or C3a.
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