Is the secondary prevention strategy with the community-based clinical path effective for the suppression of cardiovascularevents in patients with myocardial infarction?

• Project/Area Number: 22590611
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Nippon Medical School
• Principal Investigator: IBUKI Chikao 日本医科大学, 医学部, 講師 (80193639)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 心筋梗塞 / 冠動脈疾患 / 2次予防 / 地域連携 / クリニカルパス / コレステロール / 地域医療 / スタチン / 循環器 / 高血圧

Research Abstract

We investigated whether the therapeutic system with ‘the community-based clinical path for patients with acute myocardial infarction’, based on the guideline for the secondary prevention of myocardial infarction, could contribute to the recurrence of cardiovascular events in coronary heart disease (CHD) patients. We have shown that among patients with CHD 47% cases achieved the target (<100mg/dL) of LDL-cholesterol (LDL-C) proposed by the guideline. In patients treated with percutaneous coronary intervention the % reduction in LDL-C level for the early period (3 months) of the statin treatment was prerequisite for the prevention of future (5 years) coronary events. In the following interventional study focusing on the pathological significance of low level of HDL-cholesterol (HDL-C), pitavastatin administration for patients with CHD with low (< 40mg/dL) HDL-C resulted in the improvement of the lipid profile (increase in HDL-C and decrease in LDL-C/HDL-C ratio) and the reduction of high sensitive troponin T (hsTnT), suggesting that the beneficial effect of the statin treatment against cardiovascular events should be attributable not only to the improvement of the lipid profile but also the alleviation of myocaridial damage.
In conclusion our studies clarified the importance of the management of the lipid profile (LDL-C and HDL-C) and the statin treatment in terms of the secondary prevention of CHD. For efficacious management of the ’path’, we have created the educational DVD elucidating the standard care system for myocardial infarction patients, and the DVDs have being delivered to community-based physicians.

Research Products

• [Journal Article] Switching to Pitavastatin inStatin-Treated Low HDL-C Patients Further Improves the Lipid Profile and Attenuates Minute Myocardial Damage (2012)
  • Author(s): Ibuki C, Seino Y, Otsuka T, Kimata N, Inami T, Murakami D, Mizuno K
  • Journal Title: Journal of Clinical Medicine Research Volume: 4(6) Pages: 385-392
  • DOI: 10.4021/jocmr1108w
  • Peer Reviewed
• [Journal Article] Links betweensleep disordered breathing,coronaryAtherosclerotic burden, and cardiac biomarkers in patients with stable coronary artery disease (2012)
  • Author(s): Inami T, Seino Y, Otuska T, Yamamoto M, Kimata N, Murakami D, Tkano M, Ohba T, Ibuki C, Mizuno K
  • Journal Title: Journal of Cardiology Volume: 60(3) Pages: 180-186
  • Peer Reviewed
• [Journal Article] オシロメトリック法による上腕動脈面積測定の再現性および正確性に関する検討 (2012)
  • Author(s): 宗像亮、大塚俊昭、梅田宗紀、加藤活人、雪吹周生、清野精彦
  • Journal Title: THERAPEUTIC RESEARCH Volume: 33(11) Pages: 1701-1709
  • Peer Reviewed
• [Journal Article] Subjective evaluation of the frequency of salty food intake and its relationship to urinary sodium excretion and blood pressure in a middle-aged population (2012)
  • Author(s): Otsuka T, Kato K, Ibuki C, Kodani E, Kusama Y
  • Journal Title: Environ Health Prev Med Volume: Inpress
  • NAID: 10031189210
  • Peer Reviewed
• [Journal Article] Links between sleep disordered breathing, coronary atherosclerotic burden, and cardiac biomarkers in patients with stable coronary artery disease. (2012)
  • Author(s): Inami T, Seino Y, Otsuka T, Yamamoto M, Kimata N, Murakami D, Takano M, Ohba T, Ibuki C, Mizuno K
  • Journal Title: Journal of Cardiology Volume: 60 Pages: 180-186
  • Peer Reviewed
• [Journal Article] オシロメトリック法による上腕動脈面積測定の再現性および正確性に関する検討 (2012)
  • Author(s): 宗像亮、大塚俊昭、梅田宗紀、加藤活人、雪吹周生、清野精彦
  • Journal Title: THERAPEUTIC RESEARCH Volume: 33 Pages: 1701-1709
  • Peer Reviewed
• [Journal Article] Atypical Exercise Stress Myocardial Perfusion SPECT Imaging in a Patient With Effort Angina Pectoris (2011)
  • Author(s): Otsuka T, Miyauchi H, Ibuki C, Toba M, Tokuyama K, Ishii K, Kodani E, Kusama Y, Atarashi H, Kishida H, Mizuno K
  • Journal Title: Circulation Journal Volume: 75(1) Pages: 218-220
  • NAID: 10027426116
  • URL: http://dx.doi.org/10.1253/circj.CJ-10-0526
  • Peer Reviewed
• [Journal Article] The possibility of delayed arterial healing 5 years after implantation of sirolimus-eluting stents: Serial observations by coronary angioscopy (2011)
  • Author(s): Yamamoto M, Takano M, Murakami D, Inami T, Kobayashi N, Inami S, Okamatsu K, Ohba T, Ibuki C, Hata N, Mizuno K
  • Journal Title: American Heart Journal Volume: 161(6) Pages: 1200-1206
  • URL: http://dx.doi.org/10.1016/j.ahj.2011.03.006
  • Peer Reviewed
• [Journal Article] 急性心不全 (2011)
  • Author(s): 雪吹周生,清野精彦
  • Journal Title: 救急医学救急薬剤プラクティカルガイド Volume: 35(10) Pages: 1245-1251
  • Peer Reviewed
• [Journal Article] Secondary preventive effects of a calcium antagonist for ischemic heart attack: randomized parallel comparison with ss-blockers (2011)
  • Author(s): Nakagomi A, Kodani E, Takano H, Uchida T, Sato N, Ibuki C, Kusama Y, Seino Y, Munakata K, Mizuno K, Takano T
  • Journal Title: Circulation Journal Volume: 75(7) Pages: 1696-1705
  • URL: http://dx.doi.org/10.1253/circj.CJ-10-1078
  • Peer Reviewed
• [Journal Article] Atypical Exercise Stress Myocardial Perfusion SPECT Imaging in a Patient With Effort Angina Pectoris (2011)
  • Author(s): Otsuka T, Miyauchi H, Ibuki C, Toba M, Tokuyama K, Ishii K, Kodani E, Kusama Y, Atarashi H, Kishida H, Mizuno K
  • Journal Title: Circulation Journa Volume: 75(1) Pages: 218-220
  • NAID: 10027426116
  • Peer Reviewed
• [Journal Article] The Possibility of delayed arterial healing 5 years after implantation of sirolimus-eluting stents : Serial observations by coronary angioscopy (2011)
  • Author(s): Yamamoto M, Takano M, Murakami D, Inami T, Kobayashi N, Inami S, Okamatsu K, Ohba T, Ibuki C, Hata N, Mizuno K
  • Journal Title: American Heart Journal Volume: 161(6) Pages: 1200-1206
  • Peer Reviewed
• [Journal Article] Prevention of Cardiovascular events with calcium channel blocker-based combination therapies in patients with hypertension : a randomized controlled trial (2011)
  • Author(s): Matsuzaki M, Ogihara T, Umemoto S, Rakugi H, Matsuoka H, Shimada K, Abe K, Suzuki N, Eto T, Higaki J, Ito S, Kamiya A, Kikuchi K, Suzuki H, Tei C, Ohashi Y, Saruta T, Combination of Hypertension to Prevent Cardiovascular Events Triap Group (Aoki S, Ibuki C, Murakami D, Ohba T, Seimiya K, Seino Y, Takano M, Tokuyama K, Yodogawa K), K Mizuno
  • Journal Title: Journal of Hypetension Volume: 29(8) Pages: 1649-1659
  • Peer Reviewed
• [Journal Article] Secondary preventive effects of a calcium antagonist for iscemic heart attack : randomized parallel comparison with β-blockers (2011)
  • Author(s): Nakagomi A, Kodani E, Takano H, Uchida T, Sato N, Ibuki C, Kusama Y, Seino Y, Munakata K, Mizuno K, Takano T
  • Journal Title: Circulation Journa Volume: 75(7) Pages: 1696-1705
  • Peer Reviewed
• [Journal Article] Successful Blood Pressure Control with Additive Administration of Eplerenone, an Aldosterone Receptor Blocker, in a Patient with Bilateral Renovascular Hypertension Treated with Angioplasty (2010)
  • Author(s): Ibuki C, Kawamata H, Seino Y, MizunoK
  • Journal Title: Internal Medicine Volume: 49 Issue: 22 Pages: 2455-2459
  • DOI: 10.2169/internalmedicine.49.4055
  • NAID: 130000413376
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] JCS Joint Working Group, Guidelines for Diagnosis andTreatment of Patients With Vasospastic Angina (Coronary Spastic Angina) (JCS 2008) (2010)
  • Author(s): Ibuki C
  • Journal Title: Circulation Journal Volume: 74(8) Pages: 1745-1762
  • URL: http://dx.doi.org/10.1253/circj.CJ-10-74-0802
  • Peer Reviewed
• [Journal Article] Relationship Between LDL-C ReductionAfter Coronary Revascularization and Prevention of Recurrent Cardiovascular Events (2010)
  • Author(s): Nishiwaki T, Kishi D, Yoshie F, FukudaK, Ibuki C, Seino Y, Satoh M
  • Journal Title: Journal of Pharmacy & Pharmaceutical Sciences Volume: 13(2) Pages: 254-262
  • Peer Reviewed
• [Journal Article] Association between high-sensitivitycardiac troponin T levels and the predicted cardiovascular risk in middle-aged men without overt cardiovascular disease (2010)
  • Author(s): Otsuka T, Kawada T, Ibuki C, Seino Y
  • Journal Title: American Heart Journal Volume: 159(6) Issue: 6 Pages: 972-978
  • DOI: 10.1016/j.ahj.2010.02.036
  • Peer Reviewed
• [Journal Article] Relation of Smoking Status to Serum Level of N-Terminal Pro-Brain Natriuretic Peptide in Middle-Aged Men Without Overt Cardiovascular Disease (2010)
  • Author(s): Otsuka T, Kawada T, Seino Y, Ibuki C, Katsumata M, Kodani E
  • Journal Title: American Journal of Cardiology Volume: 106(10) Issue: 10 Pages: 1456-1460
  • DOI: 10.1016/j.amjcard.2010.06.075
  • Peer Reviewed
• [Journal Article] Radial Arterial Wave Reflection is Associated with the MEGA RiskPrediction Score, an Indicator of Coronary Heart Disease Risk, in Middle-Aged Men with Mild to Moderate Hypercholesterolemia (2010)
  • Author(s): Otsuka T, Kawada T, Ibuki C, Kusama Y
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 17(7) Pages: 688-694
  • NAID: 130004444441
  • URL: http://dx.doi.org/10.5551/jat.2949
  • Peer Reviewed
• [Journal Article] 妊娠後に高安動脈炎と診断し,ステロイド投与にて無事出産し得た1症例 (2010)
  • Author(s): 雪吹周生
  • Journal Title: 心臓 Volume: 42(10) Pages: 1323-1329
  • NAID: 130002147202
  • Peer Reviewed
• [Journal Article] Guidelines for Diagnosis and Treatment of Patients With Vasospastic Angina (Coronary Spastic Angina) (JCS 2008) (2010)
  • Author(s): Ibuki C, JCS Joint Working Group
  • Journal Title: Cirlucation Journal Volume: 74(8) Pages: 1745-1762
  • Peer Reviewed
• [Journal Article] Relationship Between LDL-C Reduction After Coronary Revascularization and Prevention of Recurrent Cardiovascular Events (2010)
  • Author(s): Nishiwaki T, Kishi D, Yoshie F, Fukuda K, Ibuki C, Seino Y, Satoh M
  • Journal Title: Journal of Phamacy & Phamaceutical Sciences Volume: 13(2) Pages: 254-262
  • Peer Reviewed
• [Journal Article] Association between high-sensitivity cardiac troponin T levels and the predicted cardiovascular risk in middle-aged men without overt cardiovacular disease (2010)
  • Author(s): Otsuka T, Kawada T, Ibuki C, Seino Y
  • Journal Title: American Heart Journal Volume: 59(6) Pages: 972-978
  • Peer Reviewed
• [Journal Article] Relation of Smoking Status to Serum Level of N-Terminal Pro-Brain Natriuretic Peptide in Middle-Agged Men Without Overt Cardiovascular Disease (2010)
  • Author(s): Otsuka T, Kawada T, Seino Y, Ibuki C, Katsumata M, Kodani E
  • Journal Title: American Journal of Cardiology Volume: 106(10) Pages: 1456-1460
  • Peer Reviewed
• [Journal Article] Radial Arterial Wave Reflection is Associated with the MEGA Risk Prediction Score, an Indicator of Coronary Heart Disease Risk, in Middle-Aged Men With Mild of Moderate Hypercholesterolemia (2010)
  • Author(s): Otsuka T, Kawada T, Ibuki, C, Fusama Y
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 17(7) Pages: 688-694
  • NAID: 130004444441
  • Peer Reviewed
• [Presentation] Ibuki CDrug-Acetylcholline Provocation Test for Assessment of Therapeutic Efficacyin Patients with RefractoryVasospastic Angina-Importance (2013)
  • Author(s): Murakami D
  • Organizer: 第77回日本循環器学会(ポスター)
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2013-03-17
• [Presentation] Characteristic Features of Disordered Breathing in the Convalescent PhaseDissection-Comparative Analysis withStable Coronary Artery Disease (2013)
  • Author(s): Seino Y, Kanou S, Shimura T, Kurihara O, Yamamoto M, Kimata M, Inami T, Kobayashi N, Munakata R, Ohba T, IbukiC, Seino Y, Mizuno K
  • Organizer: 第77回日本循環器学会 (Round Table Discussion)
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2013-03-15
• [Presentation] 川崎病再燃により巨大冠動脈瘤が形成され切迫破裂による大量心嚢液貯留が疑われた一例 (2013)
  • Author(s): 纐纈敦
  • Organizer: 日本循環器学会関東甲信越地方会（第227回）
  • Place of Presentation: 東京
• [Presentation] Drug-Acetylcholline Provocation Test for Assessment of Therapeutic Efficacy in Patients with Refractory Vasospastic Angina-Importance of CCB Combinatioｎ Ｔｈｅｒａｐｙ (2013)
  • Author(s): Ｍｕｒａｋａｍｉ Ｄ
  • Organizer: 日本循環器学会学術集会（第７７回）
  • Place of Presentation: 横浜
• [Presentation] Characteristic Features of Disordered Breathing in the Convalescent Phase Dissection-Comparative Analysis with Stable Coronary Artery Disease- (2013)
  • Author(s): Ｓｅｉｎｏ Ｙ
  • Organizer: 日本循環器学会学術集会（第７７回）
  • Place of Presentation: 横浜
• [Presentation] 前糖尿病と冠動脈硬化:血管内視鏡からの検討 (2012)
  • Author(s): 栗原理、雪吹周生
  • Organizer: 第26回日本冠疾患学会(一般演題)
  • Place of Presentation: 東京ステーションコンファレンス
  • Year and Date: 2012-12-13
• [Presentation] Ibuki C Impact of Prediabetic Status on Coronary Atherosclerosis: A multivesselangioscopic study (2012)
  • Author(s): Kurihara O
  • Organizer: American Heart Association Scientific Session 2012 (一般演題)
  • Place of Presentation: Los Angels Convention Center(米国)
  • Year and Date: 2012-11-07
• [Presentation] 中年男性集団における高血圧発症予測因子としての血清シスタチンCと推算糸球体濾過量の比較 (2012)
  • Author(s): 大塚俊昭、雪吹周生
  • Organizer: 第35回日本高血圧学会(ポスター)
  • Place of Presentation: ウエスティンナゴヤキャッスル(名古屋)
  • Year and Date: 2012-09-22
• [Presentation] 低HDL-C患者におけるPitavastatinへのスタチン変更はさらなる脂質プロファイル改善と微小心筋傷害軽減をもたらす (2012)
  • Author(s): 雪吹周生
  • Organizer: 第60回日本心臓病学会(ポスター)
  • Place of Presentation: 石川県立音楽堂他(金沢)
  • Year and Date: 2012-09-14
• [Presentation] バイオマーカー診断は画像診断を凌駕するか?Vulnerable Plaque and Vulnerable Blood (2012)
  • Author(s): 清野精彦、雪吹周生
  • Organizer: 第60回日本心臓病学会(教育プログラム)
  • Place of Presentation: 石川県立音楽堂他(金沢)
  • Year and Date: 2012-09-14
• [Presentation] High-Risk Plaques Associated with Peri-procedural Myocardial Injury Following Perctaneous Coronary Intervention : Assessment by High-Sensitivity Troponin-Tand Optical Coherence Tomography (2012)
  • Author(s): Kurihara O, Yamamoto M, Shimura T, Kimata N, Yamamoto T, Inami T, Munakata R, Murakami D, Abe J, Maruyama M, Takano M, Ohba T, Ibuki C, Seino Y, Mizuno K
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-18
• [Presentation] Efficacy and Limitation of Oral Inotropic Agents for the Treatment of chronic Heart Failure : Single Center Retrospective Analyses (2012)
  • Author(s): 第76回日本循環器学会
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-18
• [Presentation] Prevention of Myocardial Injury with Short=periodand High-Statin During Coronary Intervention: PRIMITIVE Study (2012)
  • Author(s): Takano H, Ibuki C
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-03-16
• [Presentation] Serum Cystatin C Predicts the 4-Year Risk of Incident Hypertension in Middle-aged Subjectswithout Chronic Kidney Disease (2012)
  • Author(s): Otsuka T, Ibuki C
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-03-16
• [Presentation] High-Risk PlaquesAssociated with Peri-procedural Myocardial Injury Following Percutaneous Coronary Intervention: Assessment by High-Sensitivity Troponin-T and Optical Coherence Tomography (2012)
  • Author(s): Kurihara O, Ibuki C
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-03-16
• [Presentation] Prevention of Myocardial Injury with Short-period and High-Statin During Coronary Intervention : PRIMITIVE Study (2012)
  • Author(s): Takano H, Ohba T, Yamamoto E, Miyachi H, Inui K, Kawanaka H, Kamiya M, Kikuchi A, Takahashi Y, Tanabe J, Inami S, Takagi G, Asai K, Yasutake M, Ibuki C, Tanaka K, Kusama Y, Seino Y, Munakata K, Mizuno K
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-16
• [Presentation] Serum Cystatin C Predicts the 4-Year Risk of Incident Hypertention in Middle-aged Subjects without Chronic Kidney Disease (2012)
  • Author(s): Otsuka T, Kato K, Kodani E, Ibuki C, Seino Y
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-16
• [Presentation] 低HDL-C患者におけるPitavastatinへのスタチン変更はさらなる脂質プロファイル改善と微小心筋傷害軽減をもたらす (2012)
  • Author(s): 雪吹周生
  • Organizer: 日本心臓病学会（第60回）
  • Place of Presentation: 金沢
• [Presentation] マラソン後心室細動を発症しBrugada症候群との鑑別を要した若年冠攣縮性狭心症の一例 (2012)
  • Author(s): 武内紗矢佳
  • Organizer: 日本循環器学会関東甲信越地方会（第224回）
  • Place of Presentation: 東京
• [Presentation] FFRを指標にPCI治療適応外とした病変部に発症した急性冠症候群の一例：OCTからの考察 (2012)
  • Author(s): 栗原理
  • Organizer: 日本血管内治療学会（第18回）
  • Place of Presentation: 東京
• [Presentation] 安定冠動脈疾患における睡眠時無呼吸と冠動脈病変の進展および心筋バイオマーカの関連性 (2012)
  • Author(s): 稲見徹
  • Organizer: 日本血管内治療学会（第18回）
  • Place of Presentation: 東京
• [Presentation] PCIに伴う心筋傷害と病変の特徴：OCTからの考察 (2012)
  • Author(s): 加納誠士
  • Organizer: 日本血管内治療学会（第18回）
  • Place of Presentation: 東京
• [Presentation] バイオマーカー診断は画像診断を凌駕するか？ Vulnerable Plaque and Vulnerable Blood (2012)
  • Author(s): 清野精彦
  • Organizer: 日本心臓病学会（第60回）
  • Place of Presentation: 金沢
  • Invited
• [Presentation] 中年男性集団における高血圧発症予測因子としての血清シスタチンCと推算糸球体濾過量の比較 (2012)
  • Author(s): 大塚俊昭
  • Organizer: 日本高血圧学会（第35回）
  • Place of Presentation: 名古屋
• [Presentation] Impact of Prediabetic Status on Coronary Atherosclerosis: A multivessel angioscopic study (2012)
  • Author(s): Kurihara O
  • Organizer: American Heart Association Scientific Sessions 2012
  • Place of Presentation: LosAngels
• [Presentation] 前糖尿病と冠動脈硬化：血管内視鏡からの検討 (2012)
  • Author(s): 栗原理
  • Organizer: 日本冠疾患学会（第26回）
  • Place of Presentation: 東京
• [Presentation] プラーク黄色度は待機的PCIにおける末梢塞栓による心筋傷害および一過性の造影遅延と強く相関する:血管内視鏡からの考察 (2011)
  • Author(s): 村上大介、高野雅充、志村徹郎、栗原理、木股仲恒、山本真功、稲見徹、宗像亮、稲見茂信、岡松健太郎、大場崇芳、雪吹周生、清野精彦、水野杏一
  • Organizer: 第25回日本心臓血管内視鏡学会
  • Place of Presentation: 京都
  • Year and Date: 2011-10-08
• [Presentation] SES留置後、長期にわたり抗血小板薬を2剤を中止したにもかかわらず、ステント血栓症に至らなかった1例:なぜステント血栓症は生じなったのか? (2011)
  • Author(s): 志村徹郎、村上大介、木股仲恒、山本真功、稲見徹、高野雅充、大場崇芳、雪吹周生、清野精彦、水野杏一
  • Organizer: 第25回日本心臓血管内視鏡学会
  • Place of Presentation: 京都
  • Year and Date: 2011-10-01
• [Presentation] 治療方針決定に難渋し肺血栓塞栓症を反復発症した外国人旅行男性の一例 (2011)
  • Author(s): 加納誠二、山本真功、栗原理、木股仲恒、白壁彰宏、稲見徹、村井綱児、村上大介、淀川顕司、阿部純子、高野雅充、丸山光紀、大場崇芳、雪吹周生、清野精彦、水野杏一
  • Organizer: 第221回日本循環器学会関東甲信越地方会
  • Place of Presentation: 東京
  • Year and Date: 2011-09-10
• [Presentation] Links between sleep apnea syndrome, coronary atherosclerotic burden and cardiac biomarkers in patients with stable coronary artery disease (2011)
  • Author(s): Inami T, Ibuki C
  • Organizer: ESC Congress 2011
  • Place of Presentation: Paris国際会議場(フランス)
  • Year and Date: 2011-08-28
• [Presentation] Links between sleep apnoea syndrome, coronary atherosclerotic burden and cardiac biomarkers in patients with stable coronary artery disease (2011)
  • Author(s): Inami T, Seino Y, Yamamoto M, Kimata N, Murakami D, Takano M, Ohba T, Ibuki C, Mizuno K
  • Organizer: ESC Congress 2011
  • Place of Presentation: パリ
  • Year and Date: 2011-08-28
• [Presentation] Detection of high risk plaque associated with periprocedural myocardial injur following percutaneous coronary intervention assessed by high-sensitivity troponin-T and optical coherence tomography (2011)
  • Author(s): Kurihara O, Ibuki C
  • Organizer: ESC Congress
  • Place of Presentation: Paris国際会議場(フランス)
  • Year and Date: 2011-08-11
• [Presentation] Detection of high risk plaque associated with periprocedural myocardial injury following perctaneous coronary intervention assessed by high-sensitivity troponin-T and optical coherence tomography (2011)
  • Author(s): Kurihara O, Yamamoto M, Seino Y, Otsuka T, Negishi K, Inami T, Murakami D, Okamatsu K, Tanako M, Ohba T, Ibuki C, Mizuno K
  • Organizer: ESC Congress
  • Place of Presentation: パリ
  • Year and Date: 2011-08-11
• [Presentation] Links between SleepApnea Syndrome and Aortic Dissection: Differences in Patent False Lumen Type versus Thrombosed Type (2011)
  • Author(s): Inami T, Ibuki C
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: パシフィコ 横浜
  • Year and Date: 2011-08-04
• [Presentation] Obesity is an IndependentDeterminant of Nocturnal Blood Pressure Lowering with Addition of Hydrochlorthiazide as the Fixed-dose Combination with Losartan (2011)
  • Author(s): Ibuki C
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-08-04
• [Presentation] Links between Sleep Apnea Syndrome and Aortic Dissection : Differences in Patent Folse Lumen Type versus Thrombossed Type (2011)
  • Author(s): Inami T, Seino Y, Kurihara O, Yamamoto M, Kimata N, Murai K, Murakami D, Takano M, Ohara T, Ibuki C, Hata N., Mizuno K
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-08-04
• [Presentation] Obesity is an Independent Determinant of Noctural Blood Pressure Loweing with Addition of Hydrochlorthiazide as the Fixed-doze Combination with Losartan (2011)
  • Author(s): Ibuki C, Seino Y, Mizuo K
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-08-04
• [Presentation] Endothelial dysfunction after SES Implantation remains even in long-term follow-up (2011)
  • Author(s): Murakami D, Yamamoto M, Kimata N, Inami T, Murai K, Takano M, Ohba T, Ibuki C, Seino Y, Mizuno K
  • Organizer: 第20回日本心血管インターベンション治療学会
  • Place of Presentation: 大阪
  • Year and Date: 2011-07-23
• [Presentation] A possibility of early stenotic progression due to lipidic plaque disruption underreceiving appropriate medical therapy (2011)
  • Author(s): Shimura T, Murakami D, Yamamoto M, Inami T, Murai K, Takano M, Ohba T, Ibuki C, Seino Y, Mizuno K
  • Organizer: 第20回日本心血管インターベンション治療学会
  • Place of Presentation: 大阪
  • Year and Date: 2011-07-22
• [Presentation] 冠動脈疾患と頸動脈疾患を合併した2例に対する治療体系構築の比較 (2011)
  • Author(s): 江渕彗悟、大場崇芳、山本真功、根岸経太、木股仲恒、稲見徹、村井綱児、村上大介、阿部純子、淀川顕司、高野雅充、大野則彦、雪吹周生、清野精彦、水野杏一
  • Organizer: 第220回日本循環器学会関東甲信越地方会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-04
• [Presentation] Obesity is an Independent Determinant of Nocturnal Blood Pressure Lowering with Addition of Hydrochlorthiazide as the Fixed-dose Combination with Losartan (2011)
  • Author(s): Ibuki C, Seino Y, Mizuno K
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-18
• [Presentation] 急性期に於ける大動脈解離と睡眠時無呼吸症候群の関連性 (2011)
  • Author(s): 稲見徹,雪吹周生
  • Organizer: 第38回日本集中治療医学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-02-26
• [Presentation] 静注強心薬離脱困難な重症心不全患者における経口強心薬治療と展望 (2011)
  • Author(s): 村井綱児,雪吹周生
  • Organizer: 第38回日本集中治療医学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-02-26
• [Presentation] 急性期に於ける大動脈解離と睡眠時無呼吸症候群の関連性 (2011)
  • Author(s): 稲見徹, 栗原理, 白壁彰宏, 小林宣明, 品田卓郎, 圷宏一, 横山真也, 雪吹周生, 畑典武, 清野精彦
  • Organizer: 第38回日本集中治療医学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-02-26
• [Presentation] 静注強心薬解離困難な重症心不全患者における経口強心薬治療と展望 (2011)
  • Author(s): 村井綱児, 清野精彦, 木股仲恒, 稲見徹, 山本真功, 村上大介, 阿部純子, 淀川顕司, 雪吹周生, 水野杏一
  • Organizer: 第38回日本集中治療医学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-02-26
• [Presentation] 高血圧患者に対するLosartan/HCTZ配合剤投与は昼間・夜間血圧いずれに対しても48週間安定した降圧効果を示す:地域連携研究"INBAstudy"より (2010)
  • Author(s): 雪吹周生
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2010-10-17
• [Presentation] 高血圧患者に対するLosartan/HCTZ配合剤投与は昼間・夜間血圧いずれに対しても48週間安定した降圧効果を示す:地域連携研究"INBA Study"より (2010)
  • Author(s): 雪吹周生, 清野精彦, 大塚俊昭, 水野杏一
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-17
• [Presentation] 「塩辛い食品」摂取状況に関する主観的評価は将来の血圧上昇を予測するか? (2010)
  • Author(s): 大塚俊昭,雪吹周生
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2010-10-16
• [Presentation] 「塩辛い食品」摂取状況に関する主婦的評価は将来の血圧上昇を予測するか? (2010)
  • Author(s): 大塚俊昭, 雪吹周生, 清野精彦, 小谷英太郎, 草間芳樹
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-16
• [Presentation] 血管内視鏡で定量的色調評価された黄色プラークとVH-IVUSで定義されたTCFAの関係 (2010)
  • Author(s): 志村徹郎, 山本真功, 高野雅充, 栗原理, 根岸経太, 村上大介, 雪吹周生, 清野精彦, 水野杏一
  • Organizer: 第24回日本心臓血管内視鏡学会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-02
• [Presentation] Losartan/HCTZ配合剤は高BMI高血圧患者において顕著な夜間降圧効果を示す:地域連携研究(INBA)study (2010)
  • Author(s): 雪吹周生
  • Organizer: 第58回日本心臓病学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-09-18
• [Presentation] Losartan/HCTZ配合剤は高BMI高血圧患者において顕著な夜間高圧効果を示す:地域連携研究(INBA)Study (2010)
  • Author(s): 雪吹周生, 清野精彦, 大塚俊昭, 水野杏一
  • Organizer: 第58回日本心臓病学会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-18
• [Presentation] 慢性腎機能障害を有する末梢動脈疾患患者に対する炭酸ガス造影DSA併用カテーテルインターベンションの有用性 (2010)
  • Author(s): 木股仲恒, 清野精彦, 山本真功, 稲見徹, 村井綱児, 村上大介, 高野雅充, 大場崇芳, 雪吹周生, 川俣博志, 水野杏一
  • Organizer: 第58回日本心臓病学会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-18
• [Presentation] 慢性心不全における経口狭心薬療法の有用性と問題点:Real World analysis (2010)
  • Author(s): 村井綱児,雪吹周生
  • Organizer: 第58回日本心臓病学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-09-17
• [Presentation] 慢性心不全における経口狭心薬療法の有用性と問題点:Real World analysis (2010)
  • Author(s): 村井綱児, 清野精彦, 木股仲恒, 山本真功, 稲見徹, 村上大介, 阿部純子, 淀川顕司, 高野雅充, 大場崇芳, 大野則彦, 雪吹周生, 水野杏一, 下村直樹, 福田恵子
  • Organizer: 第58回日本心臓病学会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-17
• [Presentation] 重度の睡眠時無呼吸症候群を合併した急性大動脈解離の1症例 (2010)
  • Author(s): 根岸経太, 栗原理, 木股仲恒, 山本真功, 村井綱児, 村上大介, 阿部純子, 淀川顕司, 高野雅充, 大野則彦, 大揚崇芳, 雪吹周生, 清野精彦, 水野杏一
  • Organizer: 第217回日本循環器学会関東甲信越地方会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-11
• [Presentation] 腎機能障害を有する閉塞性動脈硬化症患者のEVTに際し炭酸ガス造影の併用が有用であった1例 (2010)
  • Author(s): 木股仲恒, 山本真功, 稲見徹, 村上大介, 大場崇芳, 雪吹周生, 清野精彦, 川俣博, 岡田進, 水野杏一
  • Organizer: 第216回日本循環器学会関東甲信越地方会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-12
• [Book] 心筋梗塞地域連携クリニカルパスにおける2次予防戦略は心血管イベント抑制に有効か？（ＤＶＤ） (2013)
  • Author(s): 雪吹周生
  • Total Pages: 1
  • Publisher: シカケ株式会社
• [Book] 循環器疾患最新の治療2012-2013 再灌流傷害 (2012)
  • Author(s): 雪吹周生、清野精彦
  • Publisher: 株式会社南江堂
• [Book] 循環器疾患最新の治療２０１２－２０１３ :再灌流傷害 (2012)
  • Author(s): 雪吹周生、清野精彦
  • Total Pages: 6
  • Publisher: 株式会社南江堂
• [Book] ER/ICUでの薬の使い方Q&A:プロの実践と秘訣に学ぶ (2011)
  • Author(s): 雪吹周生
  • Publisher: 総合医学社
• [Book] 循環器内科学 (2010)
  • Author(s): 雪吹周生
  • Publisher: シュプリンガー・ジャパン株式会社
• [Book] 救急・集中治療ガイドライン2010-2011 (2010)
  • Author(s): 雪吹周生
  • Publisher: 総合医学社
• [Book] 治療薬ハンドブック薬剤選択と処方のポイント2011 (2010)
  • Author(s): 雪吹周生
  • Publisher: 株式会社じほう社
• [Book] 治療薬ハンドブック 薬剤選択と処方のポイント 2011 (2010)
  • Author(s): 雪吹周生
  • Total Pages: 6
  • Publisher: 株式会社じほう社
• [Book] 心筋梗塞地域連携クリニカルパスにおける2次予防戦略は心血管イベント抑制に有効か?(DVD)
  • Author(s): 雪吹周生
  • Publisher: 株式会社シカケ