| Project/Area Number |
22590623
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Osaka Prefectural Institute of Public Health |
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Principal Investigator |
YOSHIDA Toshiaki 大阪府立公衆衛生研究所, 企画総務部, 主任研究員 (00201856)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | トランスフルトリン / メトフルトリン / プロフルトリン / 防虫剤 / 曝露指標 / 尿中代謝物 / ラット / ガスクロマトグラフィー/質量分析 / 含フッ素ピレスロイド剤 / 同定 / 可塑剤 / 難燃剤 / 殺虫剤 / 有機リン系化合物 / 非職業性曝露 |
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| Research Abstract |
An accurate and precise analytical method was developed for measurement of urinary metabolites in the children exposed to organophosphorus compounds (10 insecticides and 5 flame retardants) and 2 moth repellents. In addition, the urinary excretion kinetics of the metabolites of transfluthrin and profluthrin, which are widely used as insecticides, were examined in rats. Urinary 2,3,5,6-tetrafluorobenzoic acid and 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol were considered to be optimal biomarkers for monitoring transfluthrin and profluthrin exposure, respectively.
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