| Project/Area Number |
22590633
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Ehime University (2012)
Kobe University (2010-2011) |
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Principal Investigator |
ASANO Migiwa 愛媛大学, 大学院・医学系研究科, 教授 (90283879)
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| Co-Investigator(Kenkyū-buntansha) |
UENO Yasuhiro 神戸大学, 大学院・医学研究科, 教授 (30184956)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 酸化ストレス / 過酸化脂質 / オキシステロール / 動脈硬化 / 免疫染色 / 定量分析 / アルコール / 虚血性心疾患 / 高感度分析 |
|---|
| Research Abstract |
We showed oxysterols, malondialdehyde and hexanonyl lysine were increased in atherosclerotic lesions of human aorta. Inaddition, we found 7-ketochokesterol and hexanonyl lysine were accumulated in inner media of aorta by immunohistochemical analysis. Moreover, we showed that in autopsied cases hexanonyl lysine in red blood cells and expression patterns of heat shock protein 70 in glomerular podocytes were useful markers as habitual drinking and death associated with exposure to cold respectively. These results suggest the possibility that such oxidative stress markers involving oxysterols were applied for forensic diagnosis.
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