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Molecular biological analyses of distant organ failure in tourniquet shock mice.

Research Project

Project/Area Number 22590639
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionFukushima Medical University

Principal Investigator

HIRAIWA Kouichi  福島県立医科大学, 法医学講座, 教授 (60124616)

Co-Investigator(Kenkyū-buntansha) KATO Naho  福島県立医科大学, 法医学講座, 助教 (20457766)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords法医病理学 / クラッシュ症候群
Research Abstract

Molecular biological analyses of distant organ failure were performed using tourniquet shock mice for crush syndrome. DNA microarray analysis showed increased expression levels of various genes including Hsp70, c-fos, Cox-2 in soleus muscles after ischemia/reperfusion. Gene expression changes and protein translocation were observed in kidney and liver, suggesting effects on distant organs. Apoptosis was not seen in kidney. It is considered that apoptosis is not related to distant organ failure. Oxidative stress was increased after reperfusion in blood samples. It is considered that oxidative stress induces distant organ failure.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2012 2011 2010 2009 Other

All Presentation (9 results)

  • [Presentation] 緊縛性ショックモデルマウスに対する種々の薬剤の効果2012

    • Author(s)
      西形里絵、加藤菜穂、須藤美和子、水澤郁文、栗崎恵美子、平岩幸一
    • Organizer
      第96 次日本法医学会学術全国集会
    • Year and Date
      2012-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 緊縛性ショックモデルマウスに対する薬剤の効果2011

    • Author(s)
      西形里絵、加藤菜穂、須藤美和子、水澤郁文、栗崎恵美子、平岩幸一
    • Organizer
      第12回日本法医学会学術北日本地方集会
    • Year and Date
      2011-10-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 緊縛性ショックモデルマウスに対する薬剤の効果2011

    • Author(s)
      西形里絵
    • Organizer
      第12回日本法医学会学術北日本地方集会
    • Place of Presentation
      弘前
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 緊縛性ショックモデルマウスにおける遺伝子とタンパクの発現変化2011

    • Author(s)
      西形里絵、加藤菜穂、須藤美和子、水澤郁文、栗崎恵美子、平岩幸一
    • Organizer
      第95 次日本法医学会学術全国集会
    • Year and Date
      2011-06-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 緊縛性ショックモデルマウスにおける遺伝子とタンパクの発現変化2011

    • Author(s)
      西形里絵
    • Organizer
      第95次日本法医学会学術全国集会
    • Place of Presentation
      福島
    • Year and Date
      2011-06-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 緊縛性ショックモデルマウスの諸臓器の遺伝子発現変化2010

    • Author(s)
      西形里絵
    • Organizer
      第11回日本法医学会学術北日本地方集会
    • Place of Presentation
      福島
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 緊縛性ショックモデルマウスの諸臓器の遺伝子発現変化2010

    • Author(s)
      西形里絵、加藤菜穂、須藤美和子、水澤郁文、栗崎恵美子、平岩幸一
    • Organizer
      第11回日本法医学会学術北日本地方集会
    • Year and Date
      2010-10-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 緊縛性ショックモデルマウスの後肢筋組織の遺伝子発現変化2009

    • Author(s)
      西形里絵、加藤菜穂、須藤美和子、水澤郁文、栗崎恵美子、平岩幸一
    • Organizer
      第10回日本法医学会学術北日本地方集会
    • Year and Date
      2009-09-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 緊縛性ショックモデルマウスに対する種々の薬剤の効果

    • Author(s)
      西形 里絵
    • Organizer
      第96次日本法医学会学術全国集会
    • Place of Presentation
      浜松市
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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