Molecular biological analyses of distant organ failure in tourniquet shock mice.
| Project/Area Number |
22590639
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
HIRAIWA Kouichi 福島県立医科大学, 法医学講座, 教授 (60124616)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Naho 福島県立医科大学, 法医学講座, 助教 (20457766)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 法医病理学 / クラッシュ症候群 |
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| Research Abstract |
Molecular biological analyses of distant organ failure were performed using tourniquet shock mice for crush syndrome. DNA microarray analysis showed increased expression levels of various genes including Hsp70, c-fos, Cox-2 in soleus muscles after ischemia/reperfusion. Gene expression changes and protein translocation were observed in kidney and liver, suggesting effects on distant organs. Apoptosis was not seen in kidney. It is considered that apoptosis is not related to distant organ failure. Oxidative stress was increased after reperfusion in blood samples. It is considered that oxidative stress induces distant organ failure.
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Report
(4 results)
Research Products
(9 results)
