| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Research Abstract |
Molecular biological analyses of distant organ failure were performed using tourniquet shock mice for crush syndrome. DNA microarray analysis showed increased expression levels of various genes including Hsp70, c-fos, Cox-2 in soleus muscles after ischemia/reperfusion. Gene expression changes and protein translocation were observed in kidney and liver, suggesting effects on distant organs. Apoptosis was not seen in kidney. It is considered that apoptosis is not related to distant organ failure. Oxidative stress was increased after reperfusion in blood samples. It is considered that oxidative stress induces distant organ failure.
|
