Conditioning and Extinction Learning of Visceral Pain in Human

• Project/Area Number: 22590646
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: KANO Michiko 東北大学, 医学(系)研究科(研究院), 助教 (20344658)
• Co-Investigator(Renkei-kenkyūsha): FUKUDO Shin 東北大学, 大学院医学系研究科, 教授 (80199249) ; KANAZAWA Motoyori 東北大学, 大学院医学系研究科, 講師 (70323003)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 内臓痛 / 条件付け / ニューロイメージング / 消去 / 回復 / 前頭前野 / ペインマトリックス / 食道 / 内臓感覚 / 心身相関 / 痛覚ネットワーク / 脳画像

Research Abstract

Learning and memory mechanisms involved in the processing of internal bodily sensations may be relevant for elucidating the pathophysiology of functional somatic diseases. We investigated brain processing during associative learning and modification of the learned response to visceral pain using a classical conditioning paradigm and mechanical oesophageal stimulation. Conditioning responses (CR) using visceral pain produced a neural response in the absence of physical visceral pain similar to that occurs during actual visceral pain. Frontal cortex activity may play an important role in extinction learning to regulate acquired CR. The activation in the hippocampus may be associated with memory retrieval of CR after extinction. These findings elucidate the brain mechanism underlying how aversive memory of visceral pain is modified depending on circumstantial change.

Research Products

• [Journal Article] Psychophysiological responses to visceral and somatic pain in functional chest pain identify clinically relevant pain clusters (2014)
  • Author(s): Farmer AD, Coen SJ, Kano M, Naqvi H, Paine PA, Scott SM, Furlong PL, Lightman SL, Knowles CH, Aziz Q
  • Journal Title: Neurogastroenterol Motil Volume: 26(1) Issue: 1 Pages: 139-48
  • DOI: 10.1111/nmo.12245
  • Peer Reviewed
• [Journal Article] 過敏性腸症候群における局所脳活動と神経内分泌反応 (2014)
  • Author(s): 鹿野理子、金澤素、福土審
  • Journal Title: 消化器内科 Volume: 58 Pages: 122-127
  • URL: http://www.kahyo.com/item/SH201402-582
• [Journal Article] Physiological and psychological individual differences influence resting brain function measured by ASL perfusion. (2014)
  • Author(s): Kano M, Coen SJ, Farmer AD, Aziz Q, Williams SC, Alsop DC, Fukudo S, O'Gorman RL.
  • Journal Title: Brain Struct Funct Volume: 219 Issue: 5 Pages: 1673-1684
  • DOI: 10.1007/s00429-013-0593-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Psychophysiological responses to pain identify reproducible human clusters (2014)
  • Author(s): Farmer AD, Coen SJ, Kano M, Paine PA, Shwahdi M, Jafari J, Kishor J, Worthen SF, Rossiter HE, Kumari V, Williams SC, Brammer M, Giampietro VP, Droney J, Riley J, Furlong PL, Knowles CH, Lightman SL, Aziz Q.
  • Journal Title: Pain Volume: 1 Pages: 139-48
  • Peer Reviewed
• [Journal Article] Furlong PL & Aziz Q Psychological traits influence autonomic nervous system recovery following esophageal intubation in health and functional chest pain (2013)
  • Author(s): Farmer AD, Coen SJ, Kano M, Worthen SF, Rossiter HE, Navqi H, Scott SM
  • Journal Title: Neurogastroenterol Motil Neurogastroenterol Motil Volume: 25(12) Issue: 12 Pages: 950-950
  • DOI: 10.1111/nmo.12231
  • Peer Reviewed
• [Journal Article] Physiological and psychological individual differences influence resting brain function measured by ASL perfusion (2013)
  • Author(s): Kano M, Coen SJ, Farmer AD, Aziz Q, Williams SC, Alsop DC, Fukudo S, O'Gorman RL
  • Journal Title: Brain Struct Funct Volume: (Epub ahead of print)
  • URL: http://link.springer.com/article/10.1007%2Fs00429-013-0593-8
  • Peer Reviewed
• [Journal Article] Psychophysiological responses to pain identify reproducible human clusters (2013)
  • Author(s): Farmer AD, Coen SJ, Kano M, Paine PA, Shwahdi M, Jafari J, Kishor J, Worthen SF, Rossiter HE, Kumari V, Williams SC, Brammer M, Giampietro VP, Droney J, Riley J, Furlong PL, Knowles CH, Lightman SL, Aziz Q
  • Journal Title: Pain Volume: 154(11) Issue: 11 Pages: 2266-76
  • DOI: 10.1016/j.pain.2013.05.016
  • Peer Reviewed
• [Journal Article] Preceding stimulation affects brain activation in response to colonic distention in humans. (2013)
  • Author(s): Hamaguchi T, Kano M, Kanazawa M, Itoh M, Yanai K, Fukudo S.
  • Journal Title: Psychosom Med Volume: 75 Issue: 5 Pages: 453-462
  • DOI: 10.1097/psy.0b013e3182926682
  • Peer Reviewed
• [Journal Article] Sex differences in brain response to anticipated and experienced visceral pain in healthy subjects (2013)
  • Author(s): Kano M, Farmer AD, Aziz Q, Giampietro VP, Brammer MJ, Williams SC, Fukudo S, Coen SJ
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 304(8)
  • Peer Reviewed
• [Journal Article] The alexithymic brain : The neural pathways linking alexithymia to physical disorders (2013)
  • Author(s): Kano M and Fukudo S
  • Journal Title: Biopsychosoc Medicine Volume: 7(1), (invited review) Issue: 1 Pages: 1-1
  • DOI: 10.1186/1751-0759-7-1
  • Peer Reviewed
• [Journal Article] Sex differences in brain response to anticipated and experienced visceral pain in healthy subjects. (2013)
  • Author(s): Kano M, Farmer AD, Aziz Q, Giampietro VP, Brammer MJ, Williams SC, Fukudo S, Coen SJ.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 304
  • Peer Reviewed
• [Journal Article] Sex Differences in Brain Activity to Anticipated and Experienced Visceral Pain in Healthy Subjects. (2013)
  • Author(s): Kano M, Farmer AD, Aziz Q, Giampietro V, Brammer MJ, Williams SC, Fukudo S, Coen SJ.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome (2012)
  • Author(s): Sato N, Suzuki N, Sasaki A, Aizawa E, Obayashi T, Kanazawa M, Mizuno T, Kano M, Aoki M, Fukudo S
  • Journal Title: PLoS One Volume: 7(9) Issue: 9 Pages: e42450-e42450
  • DOI: 10.1371/journal.pone.0042450
  • Peer Reviewed
• [Journal Article] Serotonin transporter gene promoter polymorphism and alexithymia (2012)
  • Author(s): Kano M, Kanazawa M, et al
  • Journal Title: Neuropsychobiology Volume: 65 Issue: 2 Pages: 76-82
  • DOI: 10.1159/000329554
  • Peer Reviewed
• [Journal Article] Serotonin transporter gene promoter polymorphism and alexithymia (2012)
  • Author(s): Kano M, Mizuno T, Fukudo S, et al
  • Journal Title: Neuropsychobiology Volume: 65 Pages: 76-82
  • Peer Reviewed
• [Journal Article] Neural substrates of decision making as measured with the Iowa Gambling Task in men with alexithymia (2011)
  • Author(s): Kano M, Fukudo S, et al
  • Journal Title: Psychosom Med Volume: 73 Issue: 7 Pages: 588-597
  • DOI: 10.1097/psy.0b013e318223c7f8
  • Peer Reviewed
• [Journal Article] Neuroticism Influences Brain Activity During the Experience of Visceral Pain (2011)
  • Author(s): Coen SJ, Kano M, Farmer AD, Kumari V, Giampietro V, Brammer M, Williams SC, Aziz Q
  • Journal Title: Gastroenterology Volume: 141 Pages: 909-911
  • Peer Reviewed
• [Journal Article] Effect of repetitive transcranial magnetic stimulation on rectal function and emo tion in humans (2011)
  • Author(s): Aizawa Y, Morishita J, Kano M, Mori T, Izumi SI, Tsutsui K, Iijima T, Kanazawa M, Fukudo S.
  • Journal Title: J Gastroenterol Volume: 46 Issue: 9 Pages: 1171-1180
  • DOI: 10.1007/s00535-011-0423-9
  • Peer Reviewed
• [Journal Article] 消化器病における性差医療:過敏性腸症候群を含む便通異常の性差 (2011)
  • Author(s): 鹿野理子、金澤素、福土審
  • Journal Title: 成人病と生活習慣病 Pages: 1431-1434
  • URL: http://www.tokyo-igakusha.co.jp/f/b/show/b01/414/zc01/1.html
  • Peer Reviewed
• [Journal Article] Neuroticism influences brain activity during the experience of visceral pain (2011)
  • Author(s): Coen SJ, Kano M, Aziz Q, et al
  • Journal Title: Gastroenterology Volume: 141 Pages: 909-917
  • Peer Reviewed
• [Journal Article] Neural substrates of decision making as measured with the Iowa Gambling Task in men with alexithymia (2011)
  • Author(s): Kano M, Ito M, Fukudo S
  • Journal Title: Psychosom Med Volume: 73 Pages: 588-597
  • Peer Reviewed
• [Journal Article] Differential responding of autonomic function to histamine H antagonism in irritable bowel syndrome (2010)
  • Author(s): Hattori T, Watanabe S, Kano M, Kanazawa M, Fukudo S.
  • Journal Title: Neurogastroenterol Motil Volume: 22 Issue: 12 Pages: 1284-1291
  • DOI: 10.1111/j.1365-2982.2010.01568.x
  • Peer Reviewed
• [Journal Article] Effect of autogenic training on general improvement in patients with irritable bowel syndrome : a randomized controlled trial (2010)
  • Author(s): Shinozaki M, Kanazawa M, Kano M, Endo Y, Nakaya N, Hongo M, Fukudo S.
  • Journal Title: Appl Psychophysiol Biofeedback Volume: 35 Issue: 3 Pages: 189-198
  • DOI: 10.1007/s10484-009-9125-y
  • Peer Reviewed
• [Journal Article] Site-specific differences in central processing of visceral stimuli from the rectum and the descending colon in men (2010)
  • Author(s): Kanazawa M, Hamaguchi T, Watanabe S, Terui T, Mine H, Kano M, Fukudo S.
  • Journal Title: Neurogastroenterol Motil Volume: 22 Issue: 2 Pages: 173-180
  • DOI: 10.1111/j.1365-2982.2009.01417.x
  • Peer Reviewed
• [Journal Article] うつ病の脳機能イメージング (2010)
  • Author(s): 鹿野理子、福土審、谷内一彦
  • Journal Title: 日本未病システム学会誌 Volume: 16 (招聘レヴュー) Pages: 35-39
  • URL: http://ci.nii.ac.jp/naid/40017252734
• [Journal Article] Differential responding of autonomic function to histamine H_1 antagonism in irritable bowel syndrome (2010)
  • Author(s): Hattori T, Watanabe S, Kano M, Kanazawa M, Fukudo S.
  • Journal Title: Neurogastroenterol Motil. Volume: 12 Pages: 1284-1291
  • Peer Reviewed
• [Journal Article] Effect of autogenic training on general improvement in patients with irritable bowel syndrome : a randomized controlled trial. (2010)
  • Author(s): Shinozaki M, Kanazawa M, Kano M, Endo Y, Nakaya N, Hongo M, Fukudo S.
  • Journal Title: Appl Psychophysiol Biofeedback. Volume: 35 Pages: 189-198
  • Peer Reviewed
• [Presentation] Increased colonic response to CRH relates to insular activity (2014)
  • Author(s): Kano M, Muratsubaki T, Yagihashi M, Morishita J, Kanazawa M, Fukudo S
  • Organizer: 72th Annual Scientific Meeting of the American Psychosomatic Society
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2014-03-14
• [Presentation] Conditioning and Extinction Learning of Visceral Pain in Healthy Subjects - An FMRI Study (2014)
  • Author(s): Kano M, Coen SJ, Farmer AD, Giampietro VP, Brammer MJ, Fukudo S, Aziz Q
  • Organizer: 7^<th> International Gastrointestinal Consensus Symposium
  • Place of Presentation: Fukushima, Japan
  • Year and Date: 2014-02-15
• [Presentation] Increased colonic responses to CRH injection in subject with IBS and insula activity. (2014)
  • Author(s): Michiko Kano, Tomohiko Muratsubaki, Mao Yagihashi, Joe Morishita, Yukari Tanaka, Motoyori Kanazawa, Shin Fukudo.
  • Organizer: 72th Annual Scientific Meeting of the American Psychosomatic Society
  • Place of Presentation: SanFrancisco, USA
• [Presentation] Influence of Serotonin Transporter Gene Variation and Anxiety-related Personality on Brain Activity during Fear Conditioning in Japanese Subjects–an fMRI study (2013)
  • Author(s): Kano M, Mizuno T, Brammer M, Aoki M, Kawashima R, Fukudo S
  • Organizer: 22^<nd> World congress on psychosomatic medicine
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2013-09-14
• [Presentation] Conditioning and extinction learning of visceral pain in healthy subjects -an fMRIstudy (2013)
  • Author(s): Kano M, Coen SJ, Farmer AD, Giampietro VP, Brammer MJ, Fukudo S, Aziz Q
  • Organizer: The 19th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Seattle, WA, USA
  • Year and Date: 2013-06-19
• [Presentation] Conditioning and Extinction Learning of Visceral Pain in Healthy Subjects - An FMRI Study (2013)
  • Author(s): Kano M, Coen SJ, Farmer AD, Giampietro VP, Brammer MJ, Fukudo S, Aziz Q
  • Organizer: The 114th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2013-05-19
• [Presentation] Conditioning and extinction learning of visceral pain in healthy subjects -an fMRIstudy (2013)
  • Author(s): Kano M, Coen SJ, Farmer AD, Giampietro VP, Brammer MJ, Fukudo S, Aziz Q
  • Organizer: 71th Annual Scientific Meeting of the American Psychosomatic Society
  • Place of Presentation: Miami, USA
  • Year and Date: 2013-03-16
• [Presentation] Conditioning and Extinction Learning of Visceral Pain in Healthy Subjects - An FMRI Study. (2013)
  • Author(s): Kano M, Coen SJ, Farmer AD, Giampietro VP, Brammer MJ, Fukudo S, Aziz Q.
  • Organizer: The 114th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: New Orleans, USA
• [Presentation] Conditioning and extinction learning of visceral pain in healthy subjects -an fMRIstudy (2013)
  • Author(s): Kano M, Coen SJ, Farmer AD, Giampietro VP, Brammer MJ, Fukudo S, Aziz Q
  • Organizer: The 19th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Seattle, USA
• [Presentation] Conditioning and Extinction Learning of Visceral Pain in Healthy Subjects – aｎ fMRI Study. (2013)
  • Author(s): Michiko Kano, Steven J Coen, Adam D Farmer, Vincent Gampietro, Mick Brammer, Shin Fukudo, Qasim Aziz
  • Organizer: American Psychosomatic Medicine, 71st Annual Scientific Meeting
  • Place of Presentation: マイアミ、米国
• [Presentation] アレキシサイミアにおける情動関連意思決定過程の脳機能画像 (2012)
  • Author(s): 鹿野理子、福土審
  • Organizer: 第17回日本心療内科学会総会・学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-11-17
• [Presentation] Gender Differences in Brain Activity Evoked by Visceral Pain in Healthy Subjects (2012)
  • Author(s): M Kano, SJ Coen, et al
  • Organizer: 70th Annual Scientific Meeting of the American Psychosomatic Society
  • Place of Presentation: アテネ、ギリシャ
  • Year and Date: 2012-03-16
• [Presentation] Gender Differences in Brain Activity Evoked by Visceral Pain in Healthy Subjects (2012)
  • Author(s): Kano M, Coen SJ, Farmer AD, Kumari V, Giampietro V, Brammer M, Williams SC, Fukudo S, Qasim Aziz
  • Organizer: 70th Annual Scientific Meeting of the American Psychosomatic Society
  • Place of Presentation: Athens, Greek
  • Year and Date: 2012-03-15
• [Presentation] Influence of Serotonin Transporter Gene Variation and Anxiety-related Personality on Brain Activity during Fear Conditioning in Japanese Subjects (2012)
  • Author(s): M Kano, T Tomoko, et al
  • Organizer: 70th Annual Scientific Meeting of the American Psychosomatic Society
  • Place of Presentation: アテネ、ギリシャ
  • Year and Date: 2012-03-15
• [Presentation] Gender Differences in Brain Activity Evoked by Visceral Pain in Healthy Subjects-an fMRI study (2012)
  • Author(s): Kano M, Coen SJ, Farmer AD, Kumari V, Giampietro V, Brammer M, Williams SC, Fukudo S, Qasim Aziz
  • Organizer: Asian Seminar
  • Place of Presentation: Soul Korea
  • Year and Date: 2012-02-16
• [Presentation] Sex Differences in Brain Activity Evoked by Visceral Pain in Healthy Subjects : an fMRI study (2012)
  • Author(s): M Kano, SJ Coen, et al
  • Organizer: Asian Seminar
  • Place of Presentation: ソウル、韓国
  • Year and Date: 2012-02-15
• [Presentation] Gender Differences in Brain Activity Evoked by Visceral Pain in Healthy Subjects (2011)
  • Author(s): Kano M, Coen SJ, Farmer AD, Kumari V, Giampietro V, Brammer M, Williams SC, Fukudo S, Aziz Q
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] Emotional Development–from Neuroimaging Studies (2011)
  • Author(s): Kano M, Fukudo S. Alextihymia and Cognitive
  • Organizer: The 21st World Congress on Psychosomatic Medicine
  • Place of Presentation: Soul, Korea
  • Year and Date: 2011-08-25
  • Invited
• [Presentation] Alextihymia and Cognitive Emotional Development-from Neuroimaging Studies (2011)
  • Author(s): Michiko Kano, Shin Fukudo
  • Organizer: The 21st World Congress on Psychosomatic Medicine
  • Place of Presentation: ソウル、韓国(招聘)
  • Year and Date: 2011-08-25
• [Presentation] Gender Differences in Brain Activity Evoked by Visceral Pain in Healthy Subjects (2011)
  • Author(s): Kano M, Coen SJ, Farmer AD, and Aziz Q
  • Organizer: British Soociety of Gastroenterology Annual Meeting
  • Place of Presentation: Plenary talk, Manchester, UK
  • Year and Date: 2011-03-16
• [Presentation] Gender Differences in Brain Activity Evoked by Visceral Pain in Healthy Subjects (2011)
  • Author(s): Kano M, Coen SJ, Farmer A, Fukudo S, Aziz Q.
  • Organizer: British Society of Gastroenterology 2011
  • Place of Presentation: Birmingham, UK
  • Year and Date: 2011-03-16
• [Presentation] Gender differences in brain activity evoked by esophagus pain in healthy subjects. (2010)
  • Author(s): Kano M, Coen SJ, Farmer A, Fukudo s, Aziz Q.
  • Organizer: 2010 Joint International Neurogastroenterology and Motility Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2010-08-10
• [Presentation] 心身相関の脳機能イメージング (2010)
  • Author(s): 鹿野理子、金澤素、Coen SJ, Farmer A, 福土審
  • Organizer: 第51回日本心身医学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-06-26
• [Presentation] Gender differences in brain activity evoked by visceral pain in healthy subjects (2010)
  • Author(s): Kano M, Coen SJ, Farmer AD, Fukudo S, Aziz Q
  • Organizer: The 111th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: New Orleans, USA
• [Presentation] アレキシサイミアにおける情動関連意思決定過程の脳機能画像
  • Author(s): 鹿野 理子、福土 審
  • Organizer: 第１７回日本心療内科学会総会・学術大会
  • Place of Presentation: 福岡
• [Book] ストレス科学事典 (2011)
  • Author(s): 鹿野理子
  • Publisher: 実務教育出版