| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In order to establish the animal model for sarcopenia, we performed comparative analyses for phenotypes and molecular mechanisms between aged Spontaneously Hypertensive Rats (SHR) and Wistar Kyoto Rats (WKY). Muscle mass, infiltration of inflammatory cells in skeletal muscle, insulin resistance, the increased expression of the genes related to muscle protein degradation and the decreased expression of the marker of muscle satellite cells were observed in aged SHR not in WKY. These results might justify aged SHR as a sacopenia model.
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