Development of therapeutic method which is based on acupuncture induced proliferation of skeletal muscle stem cells
| Project/Area Number |
22590653
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kobe University |
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Principal Investigator |
TAKAOKA Yutaka 神戸大学, 医学部附属病院, 准教授 (20332281)
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| Co-Investigator(Kenkyū-buntansha) |
ICHINOSE Akihiro 神戸大学, 医学部附属病院, 特命准教授 (90362780)
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| Co-Investigator(Renkei-kenkyūsha) |
OHTA Mika 神戸大学, 医学部附属病院, 学術推進研究員 (20274706)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 東洋医学 / 鍼灸 / 遺伝子発現解析 |
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| Research Abstract |
We studied therapeutic method utilizing electro-acupuncture which induces proliferation of skeletal muscle stem cells. Our results showed that effective stimulation condition for the proliferation of skeletal muscle stem cells was electro-acupuncture of the low-frequency up to 30 Hz,that of mixed mid-frequency and the femtosecond laser radiation. We found no cell damages after thestimulation of such electro-acupuncture and the femtosecond laser. Our analysis of the model mouse of disuse muscle atrophy showed that the electro-acupuncture could inhibit muscle atrophy, changed gene expressions, reduced protein abundance of myostatin and the correlation of AKT/mTOR/FOXO signaling was suggested. The result of our experiment also showed that the electro-acupuncture could maintain not only the muscle mass butthe contractile force of muscle
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] A web based translation program for Japanese text to Braille2010
Author(s)
Aki Sugano, Mika Ohta, Tsuyoshi Oda, Kenji Miura, Shuji Goto, Masako Matsuura, Eiichi Maeda, Toshiko Ohshima, Yuji Matsumoto, Yutaka Takaoka, eBraille
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Journal Title
Internet Research
Volume: 20(5)
Pages: 582-592
Related Report
Peer Reviewed
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