| Project/Area Number |
22590653
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General internal medicine (including Psychosomatic medicine)
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
TAKAOKA Yutaka 神戸大学, 医学部附属病院, 准教授 (20332281)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ICHINOSE Akihiro 神戸大学, 医学部附属病院, 特命准教授 (90362780)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OHTA Mika 神戸大学, 医学部附属病院, 学術推進研究員 (20274706)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 東洋医学 / 鍼灸 / 遺伝子発現解析 |
|---|
| Research Abstract |
We studied therapeutic method utilizing electro-acupuncture which induces proliferation of skeletal muscle stem cells. Our results showed that effective stimulation condition for the proliferation of skeletal muscle stem cells was electro-acupuncture of the low-frequency up to 30 Hz,that of mixed mid-frequency and the femtosecond laser radiation. We found no cell damages after thestimulation of such electro-acupuncture and the femtosecond laser. Our analysis of the model mouse of disuse muscle atrophy showed that the electro-acupuncture could inhibit muscle atrophy, changed gene expressions, reduced protein abundance of myostatin and the correlation of AKT/mTOR/FOXO signaling was suggested. The result of our experiment also showed that the electro-acupuncture could maintain not only the muscle mass butthe contractile force of muscle
|
