Elucidation of bone formation signal aimed at the development of medical treatment of osteoporosis induced by deterioration of bone formation
| Project/Area Number |
22590656
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUCHI Mika 島根大学, 医学部, 講師 (40379681)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 老年医学 / 骨粗鬆症 / 骨形成 / 骨芽細胞 / 副甲状腺ホルモン / 骨形成因子 / Tmem119 / 小胞体ストレス / 筋芽細胞 / 終末糖化産物 / Smad3 / Wnt / βカテニン / カルシウム感知受容体 / ストロンチウム / MAPキナーゼ |
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| Research Abstract |
We demonstrated that strontium exhibited anabolic action on bone partly through activating calcium-sensing receptor. We identified a smad3-related factor, Tmem119, which is induced by parathyroid hormone(PTH) and promotes osteoblast differentiation partly via Wnt signal and cross-talk with bone morphogenetic protein-Runx2 pathway. Endoplasmic reticulum stress pathway is involved in the differentiation of myoblasts into osteoblasts enhanced by Tmem119. Advanced glycation end-products inhibits osteoblast differentiation via the suppression of this pathway.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Randomized teriparatide [human parathyroid hormone(PTH)1-34]once-weekly efficacy research (TOWER)trial for examining the reduction in new vertebral fractures in subjects with primary osteoporosis and high fracture risk2012
Author(s)
Nakamura T, Sugimoto T, Nakano T, Kishimoto H, Ito M, Fukunaga H, Hagino H, SoneT, Yoshikawa H, Nishizawa Y, Fujita T, Shiraki M
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Journal Title
J Clin Endicrinol Metab
Volume: 97(9)
Pages: 3097-3106
NAID
Related Report
Peer Reviewed
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[Journal Article] Kaji H Novel parathyroid hormone-responsive smad3-related factor, Tmem119,promotes osteoblast differentiation2011
Author(s)
Hisa I, Inoue Y, Hendy GN, Canafi L, Kitazawa R, Kitazawa S, Komori T, Sugimoto T, Seino S
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Journal Title
J Biol Chem
Volume: 286(11)
Pages: 9787-9796
Related Report
Peer Reviewed
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