| Project/Area Number |
22590657
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General internal medicine (including Psychosomatic medicine)
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
UCHIDA Kouichi 山口大学, 医学部附属病院, 講師 (80397992)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TERAI Syuji 山口大学, 大学院・医学系研究科, 准教授 (00332809)
YAMAMOTO Naoki 山口大学, 大学教育機構, 講師 (90448283)
TAKAMI Taro 山口大学, 大学院・医学系研究科, 講師 (60511251)
坂井田 功 山口大学, 医学(系)研究科(研究院), 教授 (80263763)
飯塚 徳男 山口大学, 医学部附属病院, 准教授 (80332807)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 漢方薬 / 非アルコール性脂肪肝炎 / 肝線維化. / 肝線維化 / 非アルコール性脂肪性肝炎 / 肝繊維化 / 肝前癌性病変 |
|---|
| Research Abstract |
The aim of this study was to investigate whether both Dai-saiko-to (TJ-8) and Bofu-tsusho-san (TJ-62) have any influence on the development of preneoplastic lesions as well as liver fibrosis.Results: After 12 weeks, both TJ-8 and TJ-62 prevented fibrosis in a dose-dependent manner by Azan, Sirius Red, αSMA expression (p < 0.05). Hydroxyproline level in liver was decreased (mean value: CDAA+TJ-8 6.3 vs CDAA only 13.4 umol/Wg P
|
