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Elucidation of anti-metabolic syndrome effects by San'oshashinto

Research Project

Project/Area Number 22590660
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionUniversity of the Ryukyus

Principal Investigator

SAKANASHI Mayuko  琉球大学, 大学院医学研究科, 助教 (80363662)

Co-Investigator(Kenkyū-buntansha) MATSUZAKI Toshihiro  琉球大学, 大学院医学研究科, 助教 (50244330)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords漢方薬 / 東洋医学 / 虚血性心疾患 / メタボリックシンドローム / 薬理学 / 循環器学 / 循環器・高血圧
Research Abstract

San'oshashinto is one of the herbal medicines used for climacteric disorder. In ovariectomized female rats as a model of menopausal women, San'oshashinto reduces increased total cholesterol level and postprandial hyperglycemia, and so prevents the development of metabolic syndrome (MetS). Furthermore, San'oshashinto improves cardiac ischemia reperfusion injury that is the myocardial damage caused when blood supply returns to the tissue after a period of ischemia. (Cardiac ischemia reperfusion injury may develop as the result of the onset of MetS.) Emodin, one of the ingredients of San'oshashinto, participates in these beneficial effects. Especially, emodin's estrogen-like effect is involved in the card ioprotective effects on ischemia reperfusion injury.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (20 results)

All 2014 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (18 results)

  • [Journal Article] Long-Term Treatment With San'o-Shashin-To, a Kampo Medicine, Markedly Ameliorates Cardiac Ischemia-Reperfusion Injury in Ovariectomized Rats via the Redox-Dependent Mechanism2013

    • Author(s)
      Mayuko Sakanashi, Toshihiro Matsuzaki, Katsuhiko Noguchi, Junko Nakasone, Makiko Sakanashi, Taro Uchida, Mika Kina-Tanada, Haruaki Kubota, Kumiko Arakaki, Akihide Tanimoto, Nobuyuki Yanagihara, Matao Sakanashi, Yusuke Ohya , Hiroaki Masuzaki, Shogo Ishiuchi, Kazuhiro Sugahara, Masato Tsutsui
    • Journal Title

      Circulation Journal

      Volume: vol. 77, No.7 Pages: 1827-37

    • NAID

      10031173765

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-Term Treatment With San’o-Shashin-To, a Kampo Medicine, Markedly Ameliorates Cardiac Ischemia-Reperfusion Injury in Ovariectomized Rats via the Redox-Dependent Mechanism2013

    • Author(s)
      Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Sakanashi M, Uchida T, Kina-Tanada M, Kubota H, Arakaki K, Tanimoto A, Yanagihara N, Sakanashi M, Ohya Y, Masuzaki H, Ishiuchi S, Sugahara K, Tsutsui M
    • Journal Title

      Circulation Journal

      Volume: 77 Issue: 7 Pages: 1827-1837

    • DOI

      10.1253/circj.CJ-12-1434

    • NAID

      10031173765

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 三黄瀉心湯が実験的閉経モデルラットの心臓虚血再灌流障害におよぼす影響:エモジンの関与2014

    • Author(s)
      坂梨まゆ子, 松崎俊博他
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] The cardioprotective effects of San'oshashinto on ischemia/reperfusion injury in ovariectomized rats : involvement of emodin2014

    • Author(s)
      Mayuko Sakanashi, Toshihiro Matsuzaki et al
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2014-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] The cardioprotective effects of San’oshashinto on ischemia/reperfusion injury in ovariectomized rats: involvement of emodin2014

    • Author(s)
      Mayuko Sakanashi, Toshihiro Matsuaki, Katsuhiko Noguchi, Junko Nakasone, Taro Uchida, Mika Kina, Makiko Sakanashi, Haruaki Kubota, Matao Sakanashi, Masato Tsutsui
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター(宮城)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 三黄瀉心湯が実験的閉経モデルラットの心臓虚血再灌流障害におよぼす影響:エモジンの関与2014

    • Author(s)
      坂梨まゆ子,松﨑俊博、野口克彦、仲宗根淳子、内田太郎、喜名美香、久保田陽秋、坂梨真木子、筒井正人
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本市総合体育館(熊本)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 閉経モデルラットの心臓虚血再灌流障害に対する三黄瀉心湯の心保護作用:emodinの関与2013

    • Author(s)
      坂梨まゆ子, 松崎俊博他
    • Organizer
      第66回日本薬理学会西南部会
    • Place of Presentation
      福岡
    • Year and Date
      2013-11-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 三黄瀉心湯の長期投与レドックスに依存した機序を介して卵巣摘出ラットの心臓虚血再灌流障害を改善する2013

    • Author(s)
      坂梨まゆ子, 松崎俊博他
    • Organizer
      第13回日本NO学会学術集会
    • Place of Presentation
      沖縄
    • Year and Date
      2013-06-28
    • Related Report
      2013 Final Research Report
  • [Presentation] San'o-shashin-to, a Kampo Medicine, Ameliorates Cardiac Ischemia/Reperfusion Injury in Ovariectomized Rats via Suppression of Peroxynitrite Formation and Restoration of Manganese Superoxide Dismutase Activities2013

    • Author(s)
      Mayuko Sakanashi, Toshihiro Matsuzaki et al
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 三黄瀉心湯の長期投与レドックスに依存した機序を介して卵巣摘出ラットの心臓虚血再灌流障害を改善する2013

    • Author(s)
      坂梨まゆ子、松崎俊博、野口克彦、仲宗根淳子、坂梨真木子、内田太郎、棚田美香、久保田陽秋、大屋祐輔、筒井正人
    • Organizer
      第13回日本NO学会学術集会
    • Place of Presentation
      沖縄県医師会館(沖縄)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 閉経モデルラットの心臓虚血再灌流障害に対する三黄瀉心湯の心保護作用:emodinの関与2013

    • Author(s)
      坂梨まゆ子、松﨑俊博、野口克彦、仲宗根淳子、内田太郎、喜名美香、久保田陽秋、坂梨真木子、坂梨又郎、須加原一博、筒井正人
    • Organizer
      第66回日本薬理学会西南部会
    • Place of Presentation
      福岡大学(福岡)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 卵巣摘出ラットの心臓虚血再灌流障害に対する三黄瀉心湯の心保護作用2012

    • Author(s)
      坂梨まゆ子, 松崎俊博他
    • Organizer
      第65回日本薬理学会西南部会
    • Place of Presentation
      熊本
    • Year and Date
      2012-11-23
    • Related Report
      2013 Final Research Report
  • [Presentation] San-o-shashinto reduces cardiac ischemia-reperfusion injury in ovariectomized rats through selective activation of manganese superoxide dismutase2012

    • Author(s)
      Mayuko Sakanashi, Toshihiro Matsuzaki et al
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 三黄潟心湯はMn-SODの選択的な活性化により卵巣摘出ラットの虚血再潅流心機能障害を軽減する2012

    • Author(s)
      坂梨まゆ子, 他
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 三黄瀉心湯は卵巣摘出ラットの心臓虚血再灌流障害を改善する2012

    • Author(s)
      坂梨まゆ子, 松崎俊博他
    • Organizer
      第12回日本NO学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 三黄瀉心湯は酸化ストレス消去により閉経後ラットモデルの虚血再灌流心機能障害を改善する2012

    • Author(s)
      坂梨 まゆ子
    • Organizer
      第12回日本NO学会学術総会
    • Place of Presentation
      神戸国際会議場 (兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 三黄瀉心湯の長期経口投与は高脂肪食負荷ラットの血管内皮機能障害および高脂血症を改善する2011

    • Author(s)
      坂梨まゆ子, 他
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      (誌上開催)(東日本大震災のため)
    • Year and Date
      2011-03-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 三黄瀉心湯の長期経口投与は高脂肪食負荷ラットの血管内皮機能障害および高脂血症を改善する2011

    • Author(s)
      坂梨まゆ子, 松崎俊博他
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      (誌上開催/東日本大震災のため)
    • Related Report
      2013 Final Research Report
  • [Presentation] 卵巣摘出ラットの心臓虚血再灌流障害に対する三黄瀉心湯の心保護作用

    • Author(s)
      坂梨 まゆ子
    • Organizer
      第65回日本薬理学会西南部会
    • Place of Presentation
      熊本大学薬学部(熊本県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] San’oshashinto ameliorates cardiac ischemia/reperfusion injury in a menopausal rat model through the redox-dependent mechanism.

    • Author(s)
      Mayuko Sakanashi
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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