| Project/Area Number |
22590662
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
HANO Takuzo 和歌山県立医科大学, 医学部, 教授 (90156381)
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| Co-Investigator(Kenkyū-buntansha) |
KAWABE Tetsuya 和歌山県立医科大学, 医学部, 助教 (60508034)
UEYAMA Takashi 和歌山県立医科大学, 医学部, 准教授 (50264875)
MIZOKOSHI Masato 和歌山県立医科大学, 医学部, 講師 (90254531)
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| Research Collaborator |
IWANE Naomi
MIYOSHI Noriko
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 認知機能 / 腎障害 / ストレス / 微小血流 / 高血圧 / 腎血流 / 脳血流 / 交感神経刺激 / タウリン / 循環器・高血圧 / 老化 / 脳・神経 / 薬理学 |
|---|
| Research Abstract |
Aim was to know the contribution of stress on cognitive function and renal medullar function through altered microcirculation. Stress induced cognitive dysfunction in rats and taurine improved this in hypertensive rats. Stress showed no effec ts on blood flow around amygdala. Renal medulla blood flow was maintained by NO after renal nerve stimulation but significantly reduced in hypertensive rats. Senescent endothelial progenitor cell was increased in hypertensive rats and improved by chronic taurine treatment.
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