| Project/Area Number |
22590663
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Josai University |
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Principal Investigator |
OKAZAKI Mari 城西大学, 薬学部, 准教授 (50272901)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKI Hirokazu 城西大学, 薬学部, 助手 (80582238)
HIBINO Yasuhide 城西大学, 薬学部, 教授 (10189805)
KAMIUCHI Shinya 城西大学, 薬学部, 助教 (80433647)
IWATA Naohiro 城西大学, 薬学部, 助手 (50552759)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 亜硝酸塩 / 虚血性脳障害 / 一酸化窒素 / 嚥下障害 / ラット / 線条体 / ドパミン / 慢性脳低灌流 / 慢性脳低灌流障害 / 嚥下反射機能障害 / 脳血流 / tyrosine hydroxylase / NO / 脳虚血再灌漑流障害 / ストレプトゾトシン糖尿病 / 脳内NO濃度 |
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| Research Abstract |
In the present study, we investigated whether nitrite exerts protective effects against ischemic brain injury induced by middle cerebral artery occlusion following reperfusion (MCAO/Re) or by chronic cerebral hypoperfusion (2VO)in rats. We found that infract volume, edema, and the number of apoptotic cells in the rat brain determined after MCAO/Re were reduced by intravenous injection of nitrite. Chronic supplementation of nitrite improved the swallowing reflex in the 2VO rats. These results suggest that dietary supplementation of nitrite may relieve the ischemic brain injury and post-stroke dysphagia.
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