Research of the molecular mechanism which development of gout and pharmacogenetic effect of urate lowering agents
| Project/Area Number |
22590667
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
URANO Wako 東京女子医科大学, 医学部, 助教 (40277140)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 痛風 / 高尿酸血症 / 遺伝子多型 / C 統計量 / 遺伝要因 / 環境要因 / 相互作用 / 遺伝子間相互作用 / 遺伝子相互作用 / C統計量 |
|---|
| Research Abstract |
Cumulative effect of genetic polymorphisms was investigated using weighted genotype risk score (wGRS) based on the number of risk alleles on polymorphisms in the ten genes, that have been indicated to be associated with SUA. A model to discriminate gout from controls by incorporating wGRS and clinical factors was constructed. C statistics was applied to evaluate the capability of the model to discriminate gout from controls
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Report
(4 results)
Research Products
(20 results)
