Research of the molecular mechanism which development of gout and pharmacogenetic effect of urate lowering agents

• Project/Area Number: 22590667
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: URANO Wako 東京女子医科大学, 医学部, 助教 (40277140)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 痛風 / 高尿酸血症 / 遺伝子多型 / C 統計量 / 遺伝要因 / 環境要因 / 相互作用 / 遺伝子間相互作用 / 遺伝子相互作用 / C統計量

Research Abstract

Cumulative effect of genetic polymorphisms was investigated using weighted genotype risk score (wGRS) based on the number of risk alleles on polymorphisms in the ten genes, that have been indicated to be associated with SUA. A model to discriminate gout from controls by incorporating wGRS and clinical factors was constructed. C statistics was applied to evaluate the capability of the model to discriminate gout from controls

Research Products

• [Journal Article] Impact of geneticpolymorphisms on the development of gout (2013)
  • Author(s): Wako Urano, Atsuo Taniguchi, et al.
  • Journal Title: J Rheumatol Volume: (In press)
  • Peer Reviewed
• [Journal Article] Impact of genetic polymorphisms on the development of gout (2013)
  • Author(s): Wako Urano
  • Journal Title: J Rheumatol Volume: In press
  • Peer Reviewed
• [Journal Article] Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout (2010)
  • Author(s): Wako Urano, Atsuo Taniguchi, et al.
  • Journal Title: Ann Rheu Dis Volume: 69 Pages: 1232-1234
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Wako Urano, Atsuo Taniguchi, et al.
  • Journal Title: Ann Rheu Dis Volume: 69 Pages: 932-933
  • Peer Reviewed
• [Presentation] 痛風発症に関する遺伝要因の検討～遺伝子相互作用の探索～ (2012)
  • Author(s): 浦野和子
  • Organizer: 第56回日本人類遺伝学会
  • Place of Presentation: 東京
  • Year and Date: 2012-10-24
• [Presentation] 痛風発症に関する遺伝要因の検討 (2012)
  • Author(s): 浦野和子
  • Organizer: 第45回日本痛風・核酸代謝学会総会
  • Place of Presentation: 奈良
  • Year and Date: 2012-02-17
• [Presentation] 痛風発症に関する遺伝要因の検討～遺伝子間相互作用の探索～ (2012)
  • Author(s): 浦野和子
  • Organizer: 日本人類遺伝学会
  • Place of Presentation: 東京
• [Presentation] 日本人における痛風発症の疾患感受性遺伝子の検討 (2011)
  • Author(s): 浦野和子
  • Organizer: 第55回日本人類遺伝学会
  • Place of Presentation: 大宮
  • Year and Date: 2011-10-29
• [Presentation] Usefulness pf gentic polymorphisms to predict gout (2011)
  • Author(s): Wako Urano
  • Organizer: The 4^<th> East asian group of rheumatology
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2011-10-15
• [Presentation] A prediction model for gout using genetic polymorphisms of ten loci associated with serum levels of uric acid (2011)
  • Author(s): Atsuo Taniguchi
  • Organizer: The 12^<th> International congress of human genetics
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2011-10-14
• [Presentation] 遺伝要因による痛風発症の予測モデル (2011)
  • Author(s): 浦野和子
  • Organizer: 第55回日本リウマチ学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2011-07-19
• [Presentation] A prediction model for gout using genetic polymorphisms of ten loci associated with serum levels of uric acid (2011)
  • Author(s): Wako Urano
  • Organizer: 14th International Symposium on Purine and Pyrimidine Metabolism in Man
  • Place of Presentation: 東京
  • Year and Date: 2011-02-19
• [Presentation] A prediction model for gout using genetic polymorphisms of ten loci associated with serum levels of uric acid (2011)
  • Author(s): Wako Urano
  • Organizer: 14^<th> International Symposium on Purine and Pyrimidine Metabolism in Man, PP11
  • Place of Presentation: Keio Plaza Hotel (Tokyo)
  • Year and Date: 2011-02-19
• [Presentation] 痛風発症の遺伝要因に関する検討 (2011)
  • Author(s): 浦野和子
  • Organizer: 第44回日本痛風核酸代謝学会
  • Place of Presentation: 東京
  • Year and Date: 2011-02-18
• [Presentation] 痛風発症の遺伝要因に関する検討 (2011)
  • Author(s): 浦野和子
  • Organizer: 日本痛風核酸代謝学会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2011-02-18
• [Presentation] 日本人における痛風発症の疾患感受性遺伝子の検討 (2010)
  • Author(s): 浦野和子
  • Organizer: 日本人類遺伝学会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2010-10-29
• [Presentation] 日本人における ABCG2 およびGCKR 遺伝子多型と痛風発症との関連 (2010)
  • Author(s): 浦野和子
  • Organizer: 第53回人類遺伝学会
  • Year and Date: 2010-04-23
• [Presentation] 日本人におけるABCG2およびGCKR遺伝子多型と痛風発症との関連 (2010)
  • Author(s): 浦野和子
  • Organizer: 日本リウマチ学会
  • Place of Presentation: 神戸ポートピアホテル(兵庫県)
  • Year and Date: 2010-04-23
• [Remarks]
  • URL: http://www.famvir.jp/3_pathema/comment.php
• [Remarks]
  • URL: http://www.famvir.jp/3_pathema/comment02.php