| Project/Area Number |
22590671
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
HAYASHI Haruo 産業医科大学, 医学部, 非常勤医師 (80569161)
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| Co-Investigator(Kenkyū-buntansha) |
OKA Takakazu 九州大学, 医学(系)研究科(研究院), 准教授 (60291514)
米良 貴嗣 産業医科大学, 医学部, 助教 (20533053)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 心因性発熱 / ストレス性高体温症 / 慢性疲労症候群 / 不明熱 / 心身症 |
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| Research Abstract |
We investigated if stress-induced hyperthermia (SIH) is nlediated by the activation of the vesicular glutamate transporter 3 (VGLUT3)-positive sympathetic premotor neurons in the rostral medullary raphe region in a similar manner as infection/inflammation-induced fever. Rats exposed to social defeated stress exhibited a rapid increase in abdominal temperature and induced Fos, a marker of neuronal activation, in the VGLUT3-expressing neurons in the rostral medullary raphe region. Pretreatment with diazepam attenuated both SIH and Fos expression in these regions. These findings suggest that SIH is mediated by the VGLUT3-positive sympathetic premotor neurons in the rostral medullary raphe region.
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