Analysis of the mechanism of gastric tumorigenesis using mice with stomach-specific gene recombination
| Project/Area Number |
22590679
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Yoshihiro 東京大学, 医学部附属病院, 助教 (10529192)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 癌 / シグナル伝達 / 胃癌 / マウスモデル / 細胞内シグナル |
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| Research Abstract |
The aim of this study was to establish stomach-specific gene recombination mice for the research of gastric tumorigenesis. Using this model, we established highly reproducible gastric tumor model and analyzed the mechanism of carcinogenesis. We found several cytokines and intracellular kinases were involved in the gastric carcinogenesis. Role of each molecule was clarified using knockout mice and gastric cancer cell lines treated with siRNA and inhibitors.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer.2012
Author(s)
Hayakawa, Y., Hirata, Y., Sakitani, K., Nakagawa, H., Nakata, W., Kinoshita, H., Takahashi, R., Takeda, K., Ichijo, H., Maeda1, S. and Koike, K.
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Journal Title
Cancer Sci.
Volume: 103
Issue: 12
Pages: 2181-2185
DOI
Related Report
Peer Reviewed
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