A study on the relationship between duodenal acidification and dyspeptic symptom

• Project/Area Number: 22590681
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Shimane University
• Principal Investigator: ADACHI Kyoichi 島根大学, 医学部, 教授 (50192969)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: functional dyspepsia / 十二指腸 / pH / サイトカイン / ｐH

Research Abstract

Functional dyspepsia is the condition of the presence of dyspeptic symptoms, such as epigastric pain and discomfort without any organic disorders. In this study, we investigated the mechanism of occurrence of dyspeptic symptoms by examiningthe relationship with duodenal acidity, anxiety and depression. We could demonstrate that duodenal acidity during acid infusion into stomach correlated with the occurrence of dyspeptic symptoms. The results of this study were published in English medical journal.

Research Products

• [Journal Article] Association between metabolic syndrome and prevalence of gastroesophageal reflux disease in ahealth screening facility in Japan. (2013)
  • Author(s): Niigaki M, Adachi K, Hirakawa K, Furuta K, Kinoshita Y
  • Journal Title: Journal of Gastroenterology Volume: 48 Issue: 4 Pages: 463-72
  • DOI: 10.1007/s00535-012-0671-3
  • Peer Reviewed
• [Journal Article] Therapeutic effects of mosapride citrate and lansoprazole for prevention of aspiration pneumonia in patients receiving gastrostomy feeding. (2013)
  • Author(s): Takatori K, Yoshida R, Adachi K, et al.
  • Journal Title: Journal of Gastroenterology Volume: 48
  • Peer Reviewed
• [Journal Article] Radially asymmetric gastroesophageal acid reflux in the distal esophagus - Examinations with novel pH sensor catheter equipped with 8 pH sensors (2012)
  • Author(s): Ohara S, Furuta K, Adachi K, Shimura S, Fukazawa K, Aimi M, Okamoto E, KomazawaY, Kinoshita Y
  • Journal Title: Journal of Gastroenterology Volume: 47 Issue: 11 Pages: 1221-7
  • DOI: 10.1007/s00535-012-0595-y
  • Peer Reviewed
• [Journal Article] Effects of rikkunshito (TJ-43) on esophageal motor function and gastroesophageal reflux (2012)
  • Author(s): Morita T, Furuta K, Adachi K, Ohara S, Tanimura T, Koshino K, Uemura T, Naora K, Kinoshita Y
  • Journal Title: Journal of Neurogastroenterology and Motility Volume: 18 Issue: 2 Pages: 181-6
  • DOI: 10.5056/jnm.2012.18.2.181
  • Peer Reviewed
• [Journal Article] A study on the efficacy of rebamipide for patients with proton pump inhibitor-refractory non-erosive reflux disease (2012)
  • Author(s): Adachi K, Furuta K, Miwa H, Oshima T, Miki M, Komazawa Y, Iwakiri K, Furuta T, Koike T, Shimatani T, Kinoshita Y
  • Journal Title: Digestive Disease and Science Volume: 57 Issue: 6 Pages: 1609-17
  • DOI: 10.1007/s10620-012-2087-6
  • Peer Reviewed
• [Journal Article] Influence of full-body water immersion on esophageal motor function and intragastric pressure (2012)
  • Author(s): Aimi M, Furuta K, Saito T, Shimura S,Fukazawa K, Ohara S, Uno G, Tobita H, Adachi K, Kinoshita Y
  • Journal Title: Journal of Neurogastroenterology and Motility Volume: 18 Issue: 2 Pages: 194-9
  • DOI: 10.5056/jnm.2012.18.2.194
  • Peer Reviewed
• [Journal Article] Generation of dyspeptic symptoms by direct acid and water infusion into the stomachs of functional dyspepsia patients and healthy subjects (2012)
  • Author(s): Oshima T, Okugawa T, Tomita T, Sakurai J, Toyoshima F, Watari J, Yamaguchi K, Fujimoto Kazuma, Adachi K, Kinoshita Y, Kusunoki H, Haruma K, Miwa H
  • Journal Title: Alimentary Pharmacology & Therapeutics Volume: 35 Issue: 1 Pages: 175-182
  • DOI: 10.1111/j.1365-2036.2011.04918.x
  • Peer Reviewed
• [Journal Article] Predicting of the efficacy of proton pump inhibitor with non-erosive reflux disease before therapy using dual-channel 24-h esophageal pH monitoring (2012)
  • Author(s): Shimatani T, Sugimoto M, Nishino M, Adachi K, Furuta K, Ito M, Kurosawa S, Manabe N, Mannen K, Hongo M, Chiba T, Kinoshita Y, and the Acid-Related Symptom Research (ARS) Group
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 27 Issue: 5 Pages: 899-906
  • DOI: 10.1111/j.1440-1746.2011.06975.x
  • Peer Reviewed
• [Journal Article] 非びらん性胃食道逆流症(NERD)の診断と治療 (2012)
  • Author(s): 足立経一
  • Journal Title: Medical Science Digest Volume: 38 Pages: 526-529
• [Journal Article] Comparisons of symptoms reported by elderly and non-elderly patients with GERD (2012)
  • Author(s): Furuta K, Kushiyama Y, Kawashima K, Shibagaki K, Komazawa Y, Fujishiro H, Kitajima N, Adachi K, Kinoshita Y
  • Journal Title: Journal of Gastroenterology Volume: 47 Issue: 2 Pages: 136-143
  • DOI: 10.1007/s00535-011-0476-9
  • Peer Reviewed
• [Journal Article] Efficacy of pectin solution for preventing gastro-esophageal reflux events in patients with percutaneous endoscopic gastrostomy (2012)
  • Author(s): Adachi K, Furuta K, Aimi M, Fukazawa K, Shimura S, Ohara S, Nakata S, Inoue Y, Ryuko K, Ishine J, Katoh K, Hirata T, Ohhata S, Katoh S, Moriyama M, SumikawaM, Sanpei M, Kinoshita Y
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 50 Pages: 190-197
  • Peer Reviewed
• [Journal Article] Efficacy of pectin solution for preventing gastro-esophageal reflux events in patients with percutaneous endoscopic gastrostomy (2012)
  • Author(s): Adachi K, Furuta K, Aimi M, Fukazawa K, Shimura S, Ohara S, Nakata S, Inoue Y, Ryuko K, Ishine J, Katoh K, Hirata T, Ohhata S, Katoh S, Moriyama M, Sumikawa M, Sanpei M, Kinoshita Y
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Predicting of the efficacy of proton pump inhibitor with non-erosive reflux disease before therapy using dual-channel 24-h esophageal pH monitoring. Journal of Gastroenterology and Hepatology (2012)
  • Author(s): Shimatani T, Sugimoto M, Nishino M, Adachi K, Furuta K, Ito M, Kurosawa S, Manabe N, Mannen K, Hongo M, Chiba T, Kinoshita Y
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: (in press)(印刷中)
  • Peer Reviewed
• [Journal Article] Influence of full-body water immersion on esophageal motor function and intragastric pressure (2012)
  • Author(s): Aimi M, Furuta K, Saito T, Shimura S, Fukazawa K, Ohara S, Uno G, Tobita H, Adachi K, Kinoshita Y
  • Journal Title: Journal of Neurogastroenterology and Motility Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] A study on the efficacy of rebamipide for patients with proton pumpinhibitor-refractory non-erosive reflux disease. Digestive Disease and Science (2012)
  • Author(s): Adachi K, Furuta K, Miwa H, Oshima T, Miki M, Komazawa Y, Iwakiri K, Furuta T, Koike T, Shimatani T, Kinoshita Y
  • Journal Title: Digestive Disease and Science Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Radially asymmetric gastroesophageal acid reflux in the distal esophagus-Examinations with novel pH sensor catheter equipped with 8 pH sensors Journal of Gastroenterology (2012)
  • Author(s): Ohara S, Furuta K, Adachi K, Shimura S, Fukazawa K, Airai M, Okamoto E, Komazawa Y, Kinoshita Y
  • Journal Title: Journal of Gastroenterology Volume: (in press)(印刷中)
  • Peer Reviewed
• [Journal Article] Different sex-related influences of eating habits on the prevalence of reflux esophagitis in Japanese (2011)
  • Author(s): Mizuta A, Adachi K, Furuta K, Ohara S, Morita T, Koshino K, Tanaka S, Moriyama M, Sumikawa M, Sanpei M, Kinoshita Y
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 26 Issue: 6 Pages: 1060-1064
  • DOI: 10.1111/j.1440-1746.2011.06707.x
  • Peer Reviewed
• [Journal Article] Usefulness of catheterless radiotelemetry pH monitoring system to examine the relationship between duodenal acidity and upper-GI symptoms (2011)
  • Author(s): Tanimura T, Adachi K, Furuta K, OharaS, Morita T, Koshino K, Miki M, Kinoshita Y
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 26 Issue: 1 Pages: 98-103
  • DOI: 10.1111/j.1440-1746.2010.06468.x
  • Peer Reviewed
• [Journal Article] Systematic review of the epidemiology of gastroesophageal reflux disease in Japan. Journal of Gastroenterology, 46 : 1092-103, 2011 (2011)
  • Author(s): Kinoshita Y, Adachi K, Hongo M, Haruma K
  • Journal Title: Journal of Gastroenterology Volume: 46 Pages: 1092-1103
  • Peer Reviewed
• [Journal Article] Efficacy of half-solid nutrient for the elderly patients with percutaneous endoscopic gastrostomy (2011)
  • Author(s): Shizuku T, Adachi K, Furuta K, Niigaki M, Miyaoka Y, Katoh S, Kobayashi K, Otani M, Kawashima K, Otani J, Kinoshita Y
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 48 Pages: 266-229
  • Peer Reviewed
• [Journal Article] Effects of nizatidine and itopride hydrochloride on esophageal motor function (2011)
  • Author(s): Koshino K, Adachi K, Furuta K, Aimi M, Fukazawa K, Shimura S, Morita T, Nakata S, Ohara S, Tanimura T, Miki M, Kinoshit Y
  • Journal Title: Esophagus Volume: 8 Pages: 253-257
  • Peer Reviewed
• [Journal Article] Usefulness of catheterless radiotelemetry pH monitoring system to examine the relationship between duodenal acidity and upper-GI symptoms. (2011)
  • Author(s): Tanimura T, Adachi K, Furuta K, Ohara S, Morita T, Koshino K, Miki M, Kinoshita Y
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 26 Pages: 98-103
  • Peer Reviewed
• [Journal Article] Variety of symptoms reported by patients with upper gastroin testinal diseases. (2011)
  • Author(s): Nagami H, Kushiyama Y, Kakuta E, Fujishiro H, Furuta K, Komazawa Y, Hashimoto T, Tsubouchi K, Moriyama N, Adachi K, Kinoshita Y.
  • Journal Title: Esophagus Volume: 8 Pages: 39-43
  • Peer Reviewed
• [Journal Article] Different sex-related influences of eating habits on the prevalence of reflux esophagitis in Japanese. (2011)
  • Author(s): Mizuta A, Adachi K, Furuta K, Ohara S, Morita T, Koshino K, Tanaka S, Moriyama M, Sumikawa M, Sanpei M, Kinoshita Y.
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Efficacy of half-solid nutrient for the elderly patients with percutaneous endoscopic gastrostomy (2011)
  • Author(s): Shizuku T, Adachi K, Furuta K, Niigaki M, Miyaoka Y, Katoh S, Kobayashi K, Otani M, Kawashima K, Otani J, Kinoshita Y.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Effects of Mosapride on Esophageal Functions and Gastroesophageal Reflux (2010)
  • Author(s): Koshino K, Adachi K, Furuta K, Ohara S, Morita T, Nakata S, Tanimura T, Miki M, Kinoshita Y
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 25 Issue: 6 Pages: 1066-1071
  • DOI: 10.1111/j.1440-1746.2010.06280.x
  • Peer Reviewed
• [Journal Article] 胸が痛い-非心臓性胸痛の診断と治療の実際 (2010)
  • Author(s): 足立経一、谷村隆志、古田賢司、三瓶まり、木下芳一
  • Journal Title: 診断と治療 Volume: 98 Pages: 1503-1506
• [Journal Article] Effects of Mosapride on Esophageal Functions and Gastroesoph ageal Reflux. (2010)
  • Author(s): Koshino K, Adachi K, Furuta K, Ohara S, Morita T, Nakato S, Tanimura T, Miki M, Kinoshita Y.
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 25 Pages: 1066-1071
  • Peer Reviewed
• [Journal Article] Acid inhibition on first and seventh days after starting administrations of two different proton pump inhibitors in Japanese subjects : Randomized two-way crossover study. (2010)
  • Author(s): Furuta K, Adachi K, Ohara S, Morita T, Tanimura T, Koshino K, Kinoshita Y
  • Journal Title: The Journal of International Medical Research Volume: 38 Pages: 1473-1483
  • Peer Reviewed
• [Presentation] 講演「PPI 治療を再考する GERD 治療 求められる PPI とは?」 (2012)
  • Author(s): 足立経一
  • Organizer: 第98回日本消化器病学会総会 ランチョンセミナー
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2012-04-19
• [Presentation] A study on the association between metabolic syndrome and prevalence of gastroesophageal reflux disease in Japanese (2012)
  • Author(s): Adachi K, Niigaki M, Hirakawa K, Furuta K, Kinoshita Y
  • Organizer: United European Gastroenterology Week 2012
  • Place of Presentation: アムステルダム, オランダ
• [Presentation] Study of esophagogastric junction in patients with reflux esophagitis and healthy volunteers using 320 row area detector CT (2012)
  • Author(s): Fukazawa K, Furuta K, Shimura S, Kamiyama K, Aimi M, Ohara S, KajitaniT, Tsurusaki M, Kitagaki H, Adachi K, Kinoshita Y
  • Organizer: Digestive Disease Week 2012
  • Place of Presentation: サンジエゴ,米国
• [Presentation] Study of esophagogastric junction in patients with reflux esophagitis and healthy volunteers using 320 row area detector CT. (2012)
  • Author(s): Fukazawa K, Furuta K, Adachi K, et al.
  • Organizer: Digestive Disease Week 2012
  • Place of Presentation: San Diego, USA
• [Presentation] A study on the association between metabolic syndrome and prevalence of gastroesophageal reflux disease in Japanese. (2012)
  • Author(s): Adachi K, Niigaki M, Hirakawa K, at al.
  • Organizer: 20th UEGW
  • Place of Presentation: Amsterdam, Nederland
• [Presentation] Gastroesophageal reflux in patients with percutaneous endoscopic gastrostomy -comparison of two different methods of nutrient half-solidification (2011)
  • Author(s): Adachi K, Furuta K, Hara A, Sumai A, Nariai Y, Hashimoto Y, Fujii H, Kawaguchi M, Kinoshita Y
  • Organizer: 33th ESPEN (European Society for Parenteral and Enteral Nutrition) congress
  • Place of Presentation: Goteborg, Sweden
  • Year and Date: 2011-09-04
• [Presentation] Asymmetrical gastroesophageal acid reflux in distal esophagus of patients with gastroesophageal reflux disease-Examinations with newly developed pH sensor catheter equipped with 8 pH sensors (2011)
  • Author(s): Ohara S, Furuta K, Shimura S, Fukazawa K, Aimi M, Adachi K, Kinoshita Y
  • Organizer: Digestive Disease Week, 2011
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-05-09
• [Presentation] Comparisons of symptoms reported by elderly and non-elderly patients with GERD (2011)
  • Author(s): Furuta K, Kushiyama Y, Kawashiraa K, Shibagaki K, Komazawa Y, Fujishiro H, Kitajiraa N, Adachi K, Kinoshita Y
  • Organizer: Digestive Disease Week, 2011
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-05-09
• [Presentation] Changes of endoscopic gastritis after cure of H.pylori in fection (2011)
  • Author(s): Kato M, Terao S, Adachi K, Nakaj ima S, Ando T, Watanabe H, Kato T, Ida K
  • Organizer: Digestive Disease Week, 2011
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-05-09
• [Presentation] GERD・バレット食道の内視鏡診断 (2011)
  • Author(s): 足立経一
  • Organizer: 第20回日本消化器内視鏡学会四国地方会セミナー
  • Place of Presentation: 香川県立がん検診センター(高松)
  • Year and Date: 2011-01-23
• [Presentation] Gastroesophageal reflux in patients with percutaneous endoscopic gastrostomy -comparison of two different methods of nutrient half-solidification (2011)
  • Author(s): Adachi K, Furuta K, Hara A, Sumi A, Nariai Y, Hashimoto Y, Fujii H, Kawaguchi M, Kinoshita Y
  • Organizer: 33th ESPEN(European Society for Parenteral and Enteral Nutrition)congress
  • Place of Presentation: イエテボリ, スウェーデン
• [Presentation] Asymmetrical gastroesophageal acid reflux in distal esophagus of patients with gastroesophageal reflux disease -Examinations with newly developed pH sensor catheter equipped with 8 pH sensors (2011)
  • Author(s): Ohara S, Furuta K, Shimura S, FukazawaK, Aimi M, Adachi K, Kinoshita Y
  • Organizer: Digestive Disease Week 2011
  • Place of Presentation: シカゴ, 米国
• [Presentation] Comparisons of symptoms reported by elderly and non-elderly patients with GERD (2011)
  • Author(s): Furuta K, Kushiyama Y, Kawashima K, Shibagaki K, Komazawa Y, Fujishiro H, Kitajima N, Adachi K, Kinoshita Y
  • Organizer: Digestive Disease Week 2011
  • Place of Presentation: シカゴ, 米国
• [Presentation] 治療抵抗性上腹部症状に対する治療戦略 (2010)
  • Author(s): 足立経一
  • Organizer: DDW Japan 2010 ランチョンセミナー
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2010-10-15
• [Presentation] Efficacy of half-solid nutrient for the prevention of aspiration pneumonitis in elderly patients with percutaneous endoscopic gastrostomy. (2010)
  • Author(s): Shizuku T, Adachi K, Furuta K, Niigaki M, Miyaoka Y, Katoh S, Kobayashi K, Otani M, Kawashima K, Otani J, Kinoshita Y.
  • Organizer: 32th ESPEN
  • Place of Presentation: ニース・フランス
  • Year and Date: 2010-09-07
• [Presentation] The relationship between upper GI-symptoms and duodenal acidity during acid infusion into stomach. (2010)
  • Author(s): Tanimura T, Adachi K, Furuta K, Ohara S, Morita T, Koshino K, Miki M, Kinoshita Y
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: ニューオリンズ・米国
  • Year and Date: 2010-05-02
• [Presentation] Acid inhibition on first and seventh days after starting administrations of two different proton pump inhibitors in Japanese subjects : Randomized two-way crossover study. (2010)
  • Author(s): Furuta K, Adachi K, Ohara S, Morita T, Tanimura T, Koshino K, Kinoshita Y.
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: ニューオリンズ・米国
  • Year and Date: 2010-05-02
• [Presentation] Effects of Rikkunshito (TJ-43) on gastroesophageal reflux, esophageal motor functions, and salivary secretion : place bo-controlled double-blind study. (2010)
  • Author(s): Morita T, Furuta K, Adachi K, Ohara S, Tanimura T, Koshino K, Uemura T, Naora K, Kinoshita Y.
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: ニューオリンズ・米国
  • Year and Date: 2010-05-02
• [Presentation] Efficacy of half-solid nutrient for the prevention of aspiration pneumonitis in elderly patients with percutaneous endoscopic gastrostomy (2010)
  • Author(s): Shizuku T, Adachi K, Furuta K, NiigakiM, Miyaoka Y, Katoh S, Kobayashi K, Otani M, Kawashima K, Otani J, Kinoshita Y
  • Organizer: 32th ESPEN(European Society for Parenteral and Enteral Nutrition)congress
  • Place of Presentation: ニーズ, フランス
• [Presentation] The relationship between upper GI-symptoms and duodenal acidity during acid infusion into stomach (2010)
  • Author(s): Tanimura T, Adachi K, Furuta K, Ohara S, Morita T, Koshino K, Miki M, Kinoshita Y
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: ニューオリンズ, 米国
• [Presentation] Acid inhibition on first and seventh days after starting administrations oftwo different proton pump inhibitors in Japanese subjects: Randomized two-way crossover study (2010)
  • Author(s): Furuta K, Adachi K, Ohara S,Morita T, Tanimura T, Koshino K, Kinoshita Y
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: ニューオリンズ, 米国
• [Presentation] Effects of Rikkunshito(TJ-43) on gastroesophageal reflux, esophageal motor functions, and salivary secretion: placebo-controlled double-blind study (2010)
  • Author(s): Morita T, Furuta K, Adachi K, Ohara S,Tanimura T, Koshino K, Uemura T, NaoraK , Kinoshita Y
  • Organizer: Digestive Disease Week 2010
  • Place of Presentation: ニューオリンズ, 米国
• [Book] 疾患・症状別今日の治療と看護-改訂第3版 (2013)
  • Author(s): 足立経一
  • Publisher: 南江堂
• [Book] 最新医学別冊 新しい診断と治療の ABC「77」機能性食道疾患-GERD と機能性食道障害- (2013)
  • Author(s): 足立経一,森山美香,秋鹿都子,三瓶まり,古田賢司,木下芳一
  • Publisher: 最新医学社
• [Book] ガスター大辞典 (2011)
  • Author(s): 足立経一
  • Publisher: 協和企画
• [Book] レジデントのための薬物療法 消化器内科 薬のルール65! プライマリケアの必須知識 (2011)
  • Author(s): 足立経一
  • Publisher: 足立経一