| Project/Area Number |
22590684
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shimane University |
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Principal Investigator |
FURUTA Kenji 島根大学, 医学部, 講師 (40362933)
|
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| Research Collaborator |
AIMI Masahito 島根大学, 医学部, 医科医員
FUKAZAWA Kousuke 島根大学, 医学部, 医科医員
MORITO Yoshiya 島根大学, 医学部, 医科医員
MISHIRO Tuyoshi 島根大学, 医学部, 助教 (20599427)
ADACHI Kyoichi 島根大学, 医学部, 教授 (50192969)
KINOSHITA Yoshikazu 島根大学, 医学部, 教授 (30243306)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | GERD / TRP / 慢性逆流性食道炎モデル / 胃食道逆流症 / 後根神経節 |
|---|
| Research Abstract |
The mRNA expression levels of TRPV1, TRPV2, and TRPA1 in the upper and lower esophagus, and dorsal root ganglion of normal rats were examined using immunohistological and molecular biological techniques. mRNA expression levels were highest in the dorsal root ganglion, while no differences were observed between the upper and lower esophagus. In contrast, in a rat model of reflux esophagitis, the mRNA expression levels of TRPV1, TRPV2, and TRPA1 tended to be higher in the upper as compared to the lower esophagus. In our previous studies of normal subjects and patients with reflux esophagitis, no site-specific differences in regard to the levels of mRNA expression in the esophagus have been observed.
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