The significance of ES cell expressed Ras, ERas as a novel target for gastric cancer treatment

• Project/Area Number: 22590688
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nagoya City University
• Principal Investigator: KUBOTA Eiji 名古屋市立大学, 大学院・医学研究科, 研究員 (30405188)
• Co-Investigator(Kenkyū-buntansha): KATAOKA Hiromi 名古屋市立大学, 大学院・医学研究科, 准教授 (40381785) ; ASAI Kiyofumi 名古屋市立大学, 大学院・医学研究科, 教授 (70212462) ; AOYAMA Mineyoshi 名古屋市立大学, 大学院・医学研究科, 講師 (70363918) ; SUZUKI Syugo 名古屋市立大学, 大学院・医学研究科, 研究員 (60363933)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: Eras / 胃癌 / 新規治療 / ERas / 肝転移 / CPT-11 / Rapamycin / 癌 / 遺伝子 / ES細胞 / 上皮間葉移行 / 転移

Research Abstract

Despite of recent advances in therapies for cancers, it is not sufficient to improve the outcome of advanced gastric cancer patients. Therefore, it is indispensable to develop novel target molecules for gastric cancer treatment. We have previously demonstrated that ES cell-expreesed Ras, ERas is expressed in gastric cancer, and is involved in gastric cancer invasiveness and metastasis. Our data also indicated the significance of ERas as a predict biomarker for gastric cancer patients. In this study, we showed the mechanisms by which ERas enhances the metastatic ability, and a utility of ERas as a target of gastric cancer treatment.

Research Products

• [Journal Article] ERas Enhances Resistance to CPT-11 in Gastric Cancer (2011)
  • Author(s): Kubota E, Kataoka H, Tanaka M, Okamoto Y, Ebi M, Hirata Y, Murakami K, Mizoshita T, Shimura T, Mori Y, Tanida S, Kamiya T, Aoyama M, Asai K, Joh T
  • Journal Title: Anticancer Res Volume: 10 Pages: 3353-60
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21965746
  • Peer Reviewed
• [Journal Article] ERas enhances resistance to CPT-11 in gastric cancer (2011)
  • Author(s): Kubota E, Kataoka H, et al
  • Journal Title: Anticancer Res Volume: 31(10) Pages: 3353-3360
  • Peer Reviewed
• [Journal Article] Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras (ERas) signal in neuroblastoma cells (2010)
  • Author(s): Aoyama M, Kataoka H, Kubota E, Tada T, Asai K.
  • Journal Title: Int J Oncol Volume: 37 Pages: 1011-6
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20811723
  • Peer Reviewed
• [Journal Article] Role of ES Cell-Expressed Ras (ERas) in Tumorigenicity of Gastric Cancer. (2010)
  • Author(s): Kubota E, Kataoka H, Aoyama M, Mizoshita T, Mori Y, Shimura T, Tanaka M, Sasaki M, Takahashi S, Asai K, Joh T
  • Journal Title: Am J Pathol Volume: 177 Issue: 2 Pages: 955-963
  • DOI: 10.2353/ajpath.2010.091056
  • Peer Reviewed
• [Journal Article] Role of ES cell-expressed Ras, ERas in Tumorigenicity of Gastric Cancer (2010)
  • Author(s): Eiji Kubota
  • Journal Title: American Journal of Pathology Volume: 177(2) Pages: 955-963
  • Peer Reviewed
• [Presentation] (パネルディスカッション21:消化器癌の悪性度・予後における分子診断)(PD21-4)胃癌の悪性度におけるES細胞特異的Ras, ERas遺伝子発現の意義 (2011)
  • Author(s): 片岡洋望, 久保田英嗣, 他
  • Organizer: 第19回日本消化器関連学会週間
  • Place of Presentation: 福岡国際会議場,福岡
  • Year and Date: 2011-10-23
• [Presentation] (English Oral Session E4-3 Ras-related gene) (E1052) ES cell-specific Ras, ERas accelerates liver metastases of gastric cancer through epithelial-mesenchymal transition (2011)
  • Author(s): 片岡洋望, 久保田英嗣, 他
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場,名古屋
  • Year and Date: 2011-10-03
• [Presentation] Role of ES cell-expressed Ras, ERas in Tumorigenicity of Gastric Cancer (2010)
  • Author(s): 片岡洋望
  • Organizer: The 4th Japan & US CollaborationConference in Gastroenterology (JUCC)
  • Place of Presentation: 東京
  • Year and Date: 2010-11-17
• [Presentation] Role of ES cell-expressed Ras, ERas in Tumorigenicity of Gastric Cancer (2010)
  • Author(s): 片岡洋望
  • Organizer: The 4th Japan & US Collaboration Conference in Gastroenterology(JUCC)
  • Place of Presentation: 東京Inter Continental TOKYO BAY
  • Year and Date: 2010-11-17
• [Presentation] Role of ES cell-expressed Ras, ERas in Gastric Cancer (2010)
  • Author(s): 久保田英嗣
  • Organizer: 2010 Cancer Research Conference
  • Place of Presentation: カナダ
  • Year and Date: 2010-11-08