| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Unfolded protein response and autophagy are important mechanisms for the proliferation and differentiation of many types of cells, and contribute to the maintenance of homeostasis. However, the crosstalk of these mechanisms in intestinal epithelial cells are yet unknown. Here, we present that autophagy in two cultured colonic cells is induced in response to unfolded protein response mainly by the signal of IRE1α, develops to resistance to apoptosis, and contributes to the viability of cells.
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