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Tumor necrosis factor ligand superfamily member 15 induces Autophagy in colonic epithelial cells

Research Project

Project/Area Number 22590693
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionTohoku University

Principal Investigator

TAKAHASHI Seiichi  東北大学, 病院, 助教 (40312574)

Co-Investigator(Kenkyū-buntansha) KINOUCHI Yoshitaka  東北大学, 高等教育開発推進センター, 教授 (20250780)
ENDO Katsuya  東北大学, 高等教育開発推進センター, 助教 (40509197)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords炎症性腸疾患 / オートファジー / クローン病 / 小胞体ストレス / TNF-SF15
Research Abstract

Unfolded protein response and autophagy are important mechanisms for the proliferation and differentiation of many types of cells, and contribute to the maintenance of homeostasis. However, the crosstalk of these mechanisms in intestinal epithelial cells are yet unknown. Here, we present that autophagy in two cultured colonic cells is induced in response to unfolded protein response mainly by the signal of IRE1α, develops to resistance to apoptosis, and contributes to the viability of cells.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (24 results)

All 2012 2011 2010 Other

All Journal Article (21 results) (of which Peer Reviewed: 9 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Changes of faecal microbiota in patients with Crohn's disease treatedwith an elemental diet and total parenteral nutrition2012

    • Author(s)
      Shiga H, Kajiura T, Shinozaki J, Takagi S, Kinouchi Y, Takahashi S, Negoro K, Endo K, Kakuta Y, Suzuki M, Shimosegawa T
    • Journal Title

      Dig Liver Dis

      Volume: 44(99) Pages: 736-742

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IBD診療の現在腸管外病変の診断と治療2012

    • Author(s)
      遠藤克哉,高橋成一,志賀永嗣,木内喜孝,下瀬川徹
    • Journal Title

      Pharma Medica

      Volume: 30巻9号 Pages: 35-39

    • Related Report
      2012 Final Research Report
  • [Journal Article] 潰瘍性大腸炎の寛解導入におけるアサコール錠の有用性の検討2012

    • Author(s)
      志賀永嗣,遠藤克哉,高橋成一,木内喜孝,下瀬川徹
    • Journal Title

      消化器内科

      Volume: 55巻2号 Pages: 278-286

    • NAID

      40019433107

    • Related Report
      2012 Final Research Report
  • [Journal Article] ゲノムワイド関連解析からみえてきた消化器疾患わが国のクローン病の発症要因と治療抵抗性2012

    • Author(s)
      角田洋一,木内喜孝,高橋成一,下瀬川徹
    • Journal Title

      G.I.Research

      Volume: 20巻3号 Pages: 196-202

    • Related Report
      2012 Final Research Report
  • [Journal Article] 炎症性腸疾患-病因解明と診断・治療の最新知見-炎症性腸疾患の病因と病態炎症性腸疾患の遺伝要因・疾患感受性遺伝子2012

    • Author(s)
      木内喜孝,高橋成一,遠藤克哉,志賀永嗣,下瀬川徹
    • Journal Title

      日本臨床70巻増刊1炎症性腸疾患

      Pages: 66-72

    • Related Report
      2012 Final Research Report
  • [Journal Article] 炎症性腸疾患の薬物療法の極意クローン病に対するインフリキシマブの治療成績と遺伝子多型との関連2012

    • Author(s)
      遠藤克哉,諸井林太郎,高橋成一,木内喜孝,下瀬川徹
    • Journal Title

      消化器内科

      Volume: 54巻1号 Pages: 77-82

    • Related Report
      2012 Final Research Report
  • [Journal Article] Increased expression of NKX2.3 mRNA transcribed from the risk haplotype for ulcerative colitis in the involved colonic mucosa2011

    • Author(s)
      Arai T, Kakuta Y, Kinouchi Y, Kimura T, Negoro K, Aihara H, Endo K, Shiga H, Kanazawa Y, Kuroha M, Moroi R, Nagasawa H, Shimodaira Y, Takahashi S, Shimosegawa T
    • Journal Title

      Hum Immunol

      Volume: 2(7) Pages: 587-591

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IBDの最近の治療その他の治療法クローン病の栄養療法2011

    • Author(s)
      志賀永嗣,高木承,遠藤克哉,高橋成一,木内喜孝,下瀬川徹
    • Journal Title

      臨床消化器内科

      Volume: 27巻1号 Pages: 79-84

    • Related Report
      2012 Final Research Report
  • [Journal Article] 潰瘍性大腸炎の寛解維持療法とサーベイランス2011

    • Author(s)
      高橋成一,木内喜孝,下瀬川徹
    • Journal Title

      日本消化器病学会雑誌

      Volume: 108巻12号 Pages: 1983-1995

    • NAID

      10030299028

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 潰瘍性大腸炎診療の現状と今後の展望潰瘍性大腸炎の病態はどこまで解明されたか?2011

    • Author(s)
      木内喜孝,角田洋一,遠藤克哉,志賀永嗣,高橋成一,下瀬川徹
    • Journal Title

      潰瘍性大腸炎の遺伝子異常Progress in Medicine

      Volume: 31巻10号 Pages: 2327-2331

    • Related Report
      2012 Final Research Report
  • [Journal Article] 遺伝子多型による消化器疾患の理解遺伝子多型解析から炎症性腸疾患の病因解明は可能か2011

    • Author(s)
      木内喜孝,角田洋一,高橋成一,下瀬川徹
    • Journal Title

      分子消化器病

      Volume: 8巻3号 Pages: 212-219

    • Related Report
      2012 Final Research Report
  • [Journal Article] 臨床に役立つ腸管免疫学の最新のトピックスIBDの遺伝子異常2011

    • Author(s)
      木内喜孝,荒井壮,金澤義丈,角田洋一,遠藤克哉,志賀永嗣,高橋成一,下瀬川徹
    • Journal Title

      GWASがもたらした病態研究の糸口Intestine

      Volume: 15巻5号 Pages: 415-421

    • Related Report
      2012 Final Research Report
  • [Journal Article] オートファジーとクローン病2011

    • Author(s)
      高橋成一
    • Journal Title

      IBD Research

      Volume: 5巻2号 Pages: 24-31

    • Related Report
      2012 Final Research Report
  • [Journal Article] IBDの疾患感受性遺伝子を知り、治療につなげるここまで明らかになったクローン病の感受性遺伝子2011

    • Author(s)
      角田洋一,木内喜孝,高橋成一,下瀬川徹
    • Journal Title

      IBD Research

      Volume: 5巻2号 Pages: 82-88

    • Related Report
      2012 Final Research Report
  • [Journal Article] クローン病の長期予後改善をめざして生物学的製剤によるクローン病の寛解維持療法infliximab計画的維持投与の治療効果を中心に2011

    • Author(s)
      遠藤克哉,志賀永嗣,角田洋一,高橋成一,木内喜孝,下瀬川徹
    • Journal Title

      日本消化器病学会雑誌

      Volume: 108巻3号 Pages: 401-409

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] クローン病の長期予後改善をめざしてクローン病の長期予後2011

    • Author(s)
      木内喜孝,角田洋一,高橋成一,下瀬川徹
    • Journal Title

      日本消化器病学会雑誌

      Volume: 108巻3号 Pages: 381-387

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Scheduled maintenance therapy with infliximab improves the prognosis of Crohn's disease: A single center prospective cohort study in Japan2010

    • Author(s)
      Takahashi S, Takagi S, Shiga H, Umemura K, Endo K, Kakuta Y, Takahashi S, Kinouchi Y, Shimosegawa T
    • Journal Title

      Tohoku J Exp Med

      Volume: 220(3) Pages: 207-15

    • NAID

      10027083563

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tooru Shimosegawa. What Determines the Later Clinical Course of Patients Who Do Not Undergo Colectomy at the First Attack? A Japanese Cohort Study on Ulcerative Colitis2010

    • Author(s)
      Shiga H, Takagi S, Inoue S, Kinouchi Y, Ohkubo T, Takahashi S, Negoro K, Yokoyama H, Kato S, Fukushima K, Hiwatashi N
    • Journal Title

      Digestion

      Volume: 81(2) Pages: 104-112

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of NF-kappa B pathway in TL1A gene expression induced by lipopolysaccharide2010

    • Author(s)
      Endo K, Kinouchi Y, Kakuta Y, Ueki N, Takahashi S, Shimosegawa T
    • Journal Title

      Cytokine

      Volume: 49 Pages: 215-220

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 炎症性腸疾患の今日的アプローチ遺伝子異常面からみた炎症性腸疾患2010

    • Author(s)
      角田洋一,木内喜孝,高橋成一,下瀬川徹
    • Journal Title

      成人病と生活習慣病

      Volume: 40巻12号 Pages: 1351-1356

    • Related Report
      2012 Final Research Report
  • [Journal Article] クローン病の診断・治療の最前線疾患感受性遺伝子からみたクローン病2010

    • Author(s)
      木内喜孝,高橋成一,下瀬川徹
    • Journal Title

      日本消化器病学会雑誌

      Volume: 107巻6号 Pages: 855-862

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] FCGR3A遺伝子多型とInfliximabの治療効果の相関から考えるクローン病の基本病態2012

    • Author(s)
      諸井林太郎,遠藤克哉,木内喜孝,只野敏浩,川上瑶子,奈良志博,松下勝則,宮澤輝子,下平陽介,長澤仁嗣,志賀永嗣,根来健一,相原裕之,高橋成一,下瀬川徹
    • Organizer
      日本消化器病学会総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 日本人炎症性腸疾患患者におけるXBP1遺伝子の解析2011

    • Author(s)
      長澤仁嗣,角田洋一,奈良志博,平本圭一郎,松下勝則,宮澤輝子,下平陽介,諸井林太郎,黒羽正剛,志賀永嗣,遠藤克哉,高橋成一,木内喜孝,下瀬川徹
    • Organizer
      日本消化器関連学会週間
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-20
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.gastroente.med.tohoku.ac.jp

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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