Tumor necrosis factor ligand superfamily member 15 induces Autophagy in colonic epithelial cells
| Project/Area Number |
22590693
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KINOUCHI Yoshitaka 東北大学, 高等教育開発推進センター, 教授 (20250780)
ENDO Katsuya 東北大学, 高等教育開発推進センター, 助教 (40509197)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炎症性腸疾患 / オートファジー / クローン病 / 小胞体ストレス / TNF-SF15 |
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| Research Abstract |
Unfolded protein response and autophagy are important mechanisms for the proliferation and differentiation of many types of cells, and contribute to the maintenance of homeostasis. However, the crosstalk of these mechanisms in intestinal epithelial cells are yet unknown. Here, we present that autophagy in two cultured colonic cells is induced in response to unfolded protein response mainly by the signal of IRE1α, develops to resistance to apoptosis, and contributes to the viability of cells.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Changes of faecal microbiota in patients with Crohn's disease treatedwith an elemental diet and total parenteral nutrition2012
Author(s)
Shiga H, Kajiura T, Shinozaki J, Takagi S, Kinouchi Y, Takahashi S, Negoro K, Endo K, Kakuta Y, Suzuki M, Shimosegawa T
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Journal Title
Dig Liver Dis
Volume: 44(99)
Pages: 736-742
Related Report
Peer Reviewed
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[Journal Article] Increased expression of NKX2.3 mRNA transcribed from the risk haplotype for ulcerative colitis in the involved colonic mucosa2011
Author(s)
Arai T, Kakuta Y, Kinouchi Y, Kimura T, Negoro K, Aihara H, Endo K, Shiga H, Kanazawa Y, Kuroha M, Moroi R, Nagasawa H, Shimodaira Y, Takahashi S, Shimosegawa T
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Journal Title
Hum Immunol
Volume: 2(7)
Pages: 587-591
Related Report
Peer Reviewed
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[Journal Article] Tooru Shimosegawa. What Determines the Later Clinical Course of Patients Who Do Not Undergo Colectomy at the First Attack? A Japanese Cohort Study on Ulcerative Colitis2010
Author(s)
Shiga H, Takagi S, Inoue S, Kinouchi Y, Ohkubo T, Takahashi S, Negoro K, Yokoyama H, Kato S, Fukushima K, Hiwatashi N
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Journal Title
Digestion
Volume: 81(2)
Pages: 104-112
Related Report
Peer Reviewed
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[Presentation] FCGR3A遺伝子多型とInfliximabの治療効果の相関から考えるクローン病の基本病態2012
Author(s)
諸井林太郎,遠藤克哉,木内喜孝,只野敏浩,川上瑶子,奈良志博,松下勝則,宮澤輝子,下平陽介,長澤仁嗣,志賀永嗣,根来健一,相原裕之,高橋成一,下瀬川徹
Organizer
日本消化器病学会総会
Place of Presentation
鹿児島
Year and Date
2012-03-23
Related Report
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[Presentation] 日本人炎症性腸疾患患者におけるXBP1遺伝子の解析2011
Author(s)
長澤仁嗣,角田洋一,奈良志博,平本圭一郎,松下勝則,宮澤輝子,下平陽介,諸井林太郎,黒羽正剛,志賀永嗣,遠藤克哉,高橋成一,木内喜孝,下瀬川徹
Organizer
日本消化器関連学会週間
Place of Presentation
福岡
Year and Date
2011-10-20
Related Report
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