| Project/Area Number |
22590696
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NAGANUMA Makoto 東京医科歯科大学, 医学部, 非常勤講師 (00265810)
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| Co-Investigator(Kenkyū-buntansha) |
NAGISHI Takashi 東京医科歯科大学, 医学部附属病院, 助教 (60447464)
WATANABE Mamoru 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (10175127)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炎症性腸疾患 / 炎症性発癌 / 新規治療法 / 粘膜免疫 / MLCK / 炎症性腸管 |
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| Research Abstract |
Treatment with anti-tumor necrosis factor (TNF) mAb has been accepted as a successful therapy for patients with inflammatory bowel diseases (IBD). It has been recently reported that blockade of TNF receptor (TNFR) signaling in infiltrating hematopoietic cells may prevents the development of colitis-associated cancer (CAC). However, it remains unclear whether the TNF signaling in the epithelial cells is also involved in the development of CAC. To investigate this, we studied the effects of anti-TNF mAb in animal models of colitis and CAC. Our studies suggest that the TNFR signaling in intestinal epithelial cells may be directly involved in the development of CAC with persistent colitis, and imply that the maintenance therapy with anti-TNF mAb may prevent the development of CAC in patients with IBD.
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