Development of chemoprevention and therapy against colorectal cancers by bone marrow mesenchymal stem cell transplantation
| Project/Area Number |
22590703
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARIMURA Yoshiaki 札幌医科大学, 医学部, 講師 (80305218)
MOTOYA Masayo (HOSOKAWA Masayo) 札幌医科大学, オホーツク医療環境研究講座, 助教 (60468080)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨髄間葉系幹細胞(MSC) / 血管新生 / CXCL12 / 骨髄間葉系幹細胞（MSC） / 腫瘍血管新生 / activation-induced cytidine deaminase (AID) / CXCL12(4) / xenoraft / SDF-1/CXCR4 / VEGF / 血管周皮細胞 |
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| Research Abstract |
MSC contributed to tumor engraftment via CXCL12/CXCR4 signaling and tumor progression through promoting angiogenesis. The mechanism of CXCL12 activation remains to be elucidated because it appears to be regulated by neither epigenetics nor miRNAs. These information concerning tumorigenic effects of MSC is necessity for clinical use of MSC therapy in the near future.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Insulin-like growth factor-I receptor blockade reduces tumor angiogenesis and enhances the effects of bevacizumab for a human gastric cancer cell line2011
Author(s)
Li H, Adachi Y, Yamamoto H, Min Y, Ohashi H, Ii M, Arimura Y, Endo T, Lee CT, Carbone DP, Imai K, Shinomura Y
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Journal Title
MKN45. Cancer
Volume: 117
Pages: 3135-3147
Related Report
Peer Reviewed
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[Journal Article] Myogenic lineage differentiated mesenchymal stem cells enhance recovery from dextran sulfate sodium-induced colitis in the rat2011
Author(s)
Tanaka H, Arimura Y, Yabana T, Goto A, Hosokawa M, Nagaishi K, Yamashita K, Yamamoto H, Sasaki Y, Fujimiya M, ImaiK, Shinomura Y
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Journal Title
J Gastroenterol
Volume: 46
Pages: 143-152
NAID
Related Report
Peer Reviewed
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[Journal Article] Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers2010
Author(s)
Wang Y, Adachi Y, Imsumran A, Yamamoto H, Piao W, Li H, Ii M, Arimura Y, Park MY, Kim D, Lee CT, Carbone DP, Imai K, Shinomura Y
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Journal Title
J Gastroenterol
Volume: 45
Pages: 159-170
NAID
Related Report
Peer Reviewed
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[Presentation] Enhancing mucosal reparative response in rat DSS colitis by mesenchymal stem cell therapy2010
Author(s)
Tanaka H, Arimura Y, Yabana T, Goto A, Hosokawa M, Nagaishi K, Naishiro Y, Yamashita K, Yamamoto H, Murata M, Fujimiya M, Imai K, Shinomura Y
Organizer
4th Korea-Japan IBD Symposium
Place of Presentation
Tokyo
Year and Date
2010-01-23
Related Report
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