Detection of methylglyoxal-modified Hsp27 and its role of colon carcinogenesis

• Project/Area Number: 22590705
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: NAITO Yuji 京都府立医科大学, 医学(系)研究科, 准教授 (00305575)
• Co-Investigator(Kenkyū-buntansha): TAKAGI Tomohisa 京都府立医科大学, 医学(系)研究科, 講師 (70405257) ; ITO Tomoko (OYA Tomoko) 京都府立医科大学, 医学(系)研究科, 准教授 (80329648)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 大腸癌 / 熱ショックタンパク質 / メチルグリオキザール / 翻訳後修飾 / アポトーシス / 運動療法 / 熱ショック蛋白質27

Research Abstract

Methylglyoxal (MG) is a reactive dicarbonyl compound produced from cellular glycolytic intermediates that reacts non-enzymatically with proteins. We found that heat shock protein 27 (Hsp27) was modified by MG in patients with cancers of ascending colon and rectum, but in non-cancerous cell lines or in normal subject. MG modification of Hsp27 protected the cells against apoptotic signaling. Our results suggest that posttranslational modification of Hsp27 by MG may have important implications for colon carcinogenesis.

Research Products

• [Journal Article] A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise (2013)
  • Author(s): Aoi W, Naito Y, Takagi T, Tanimura Y, Takanami Y, Kawai Y, Sakuma K, Hang LP, Mizushima K, Hirai Y, Koyama R, Wada S, Higashi A, Kokura S, Ichikawa H, Yoshikawa T.
  • Journal Title: Gut Volume: 62 Pages: 882-9
  • Peer Reviewed
• [Journal Article] BTB and CNC homolog 1 (Bach1) deficiency ameliorates TNBS colitis in mice: role of M2 macrophages and heme oxygenase-1 (2013)
  • Author(s): Harusato A, Naito Y, Takagi T, Uchiyama K, Mizushima K, Hirai Y, Higashimura Y, Katada K, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Muto A, Igarashi K, Yoshikawa T
  • Journal Title: Inflamm Bowel Dis Volume: 19 Pages: 740-53
  • Peer Reviewed
• [Journal Article] Role of metallothionein in murine experimental colitis (2013)
  • Author(s): Tsuji T, Naito Y, Takagi T, Kugai M, Yoriki H, Horie R, Fukui A, Mizushima K, Hirai Y, Katada K, Kamada K, Uchiyama K, Handa O, Konishi H, Yagi N, Ichikawa H, Yanagisawa R, Suzuki JS, Takano H, Satoh M, Yoshikawa T
  • Journal Title: Int J Mol Med Volume: 31 Pages: 1037-46
  • Peer Reviewed
• [Journal Article] Hemin ameliorates indomethacin-induced small intestinal injury in mice through the induction of heme oxygenase-1 (2013)
  • Author(s): Yoriki H, Naito Y, Takagi T, Mizusima K, Hirai Y, Harusato A, Yamada S, Tsuji T, Kugai M, Fukui A, Higashimura Y, Katada K, Kamada K, Uchiyama K, Handa O, Yagi N, Ichikawa H, Yosikawa T
  • Journal Title: J Gastroenterol Hepatol Volume: 28 Pages: 632-8
  • Peer Reviewed
• [Journal Article] BTB and CNC Homolog 1 (Bach1) Deficiency Ameliorates TNBS Colitis in Mice: Role of M2 Macrophages and Heme Oxygenase-1 (2013)
  • Author(s): Harusato, A. Naito, Y. Takagi, T. Uchiyama, K. Mizushima, K. Hirai, Y. Higashimura, Y. Katada, K. Handa, O. Ishikawa, T. Yagi, N. Kokura, S. Ichikawa, H. Muto, A. Igarashi, K. Yoshikawa, T.
  • Journal Title: Inflamm Bowel Dis Volume: 19 Issue: 4 Pages: 740-753
  • DOI: 10.1097/mib.0b013e3182802968
  • Peer Reviewed
• [Journal Article] Exercise-induced muscle damage impairs insulin signaling pathway associated with IRS-1 oxidative modification (2012)
  • Author(s): Aoi W, Naito Y, Tokuda H, Tanimura Y, Oya-Ito T, Yoshikawa T
  • Journal Title: Physiol Res Volume: 61 Pages: 91-8
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• [Journal Article] Acetyl salicylic acid induces damage to intestinal epithelial cells by oxidation-related modifications of ZO-1 (2012)
  • Author(s): Fukui A, Naito Y, Handa O, Kugai M, Tsuji T, Yoriki H, Qin Y, Adachi S, Higashimura Y, Mizushima K, Kamada K, Katada K, Uchiyama K, Ishikawa T, Takagi T, Yagi N, Kokura S, Yoshikawa T
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 303
  • Peer Reviewed
• [Journal Article] Oligosaccharides from agar inhibit murine intestinal inflammation through the induction of heme oxygenase-1 expression (2012)
  • Author(s): Higashimura Y, Naito Y, Takagi T, Mizushima K, Hirai Y, Harusato A, Ohnogi H, Yamaji R, Inui H, Nakano Y, Yoshikawa T
  • Journal Title: J Gastroenterol
  • NAID: 10031195116
  • Peer Reviewed
• [Journal Article] A questionnaire-based survey on screening for gastric and colorectal cancer by physicians in East Asian countries in 2010 (2012)
  • Author(s): Naito Y, Uchiyama K, Kinoshita Y, Fukudo S, Joh T, Suzuki H, Takahashi S, Ueno F, Fujiwara Y, Arakawa T, Matsumoto T, Hahm KB, Kachintorn U, Syam AF, Rani AA, Sollano JD, Zhu Q
  • Journal Title: Digestion Volume: 86 Pages: 94-106
  • Peer Reviewed
• [Journal Article] Naito Y, Uchiyama K, Takagi T, Yoshikawa T (2012)
  • Author(s): Naito Y, Uchiyama K, Takagi T, Yoshikawa T
  • Journal Title: Curr Med Chem Volume: 19 Pages: 70-6
  • Peer Reviewed
• [Journal Article] Detection of N-(hexanoyl)lysine in the tropomyosin 1 protein in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric cancer cells (2012)
  • Author(s): Okada H, Naito Y, Takagi T, Takaoka M, Oya-Ito T, Fukumoto K, Uchiyama K, Handa O, Kokura S, Nagano Y, Matsui H, Kato Y, Osawa T, Yoshikawa T
  • Journal Title: J Clin Biochem Nutr Volume: 50 Pages: 47-52
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• [Journal Article] Hemopexin is upregulated in rat intestinal mucosa injured by indomethacin (2012)
  • Author(s): Takagi T, Naito Y, Okada H, Takaoka M, Oya-Ito T, Yamada S, Hirai Y, Mizushima K, Yoshida N, Kamada K, Katada K, Uchiyama K, Ishikawa T, Handa O, Yagi N, Konishi H, Kokura S, Ichikawa H, Yoshikawa T
  • Journal Title: J Gastroenterol Hepatol Volume: 27 Suppl 3 Pages: 70-5
  • Peer Reviewed
• [Journal Article] The role of methylglyoxal-modified proteins in gastric ulcer healing (2012)
  • Author(s): Takagi T, Naito Y, Oya-Ito T, Yoshikawa T
  • Journal Title: The role of methylglyoxal-modified proteins in gastric ulcer healing Volume: 19 Pages: 137-44
  • Peer Reviewed
• [Journal Article] Colonic insufflation with carbon monoxide gas inhibits the development of intestinal inflammation in rats (2012)
  • Author(s): Takagi T, Naito Y, Uchiyama K, Okuda T, Suzuki T, Tsuboi H, Mizushima K, Handa O, Yagi N, Ichikawa H, Yoshikawa T
  • Journal Title: Med Gas Res Volume: 2 Pages: 23-23
  • Peer Reviewed
• [Journal Article] Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis (2012)
  • Author(s): Uchiyama K, Naito Y, Takagi T, Mizushima K, Hirai Y, Hayashi N, Harusato A, Inoue K, Fukumoto K, Yamada S, Handa O, Ishikawa T, Yagi N, Kokura S, Yoshikawa T
  • Journal Title: Am J PhysiolGastrointest Liver Physiol in press
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• [Journal Article] Clinical studies of molecular targeted therapies for inflammatory bowel disease (2012)
  • Author(s): Uchiyama K, Takagi T, Naito Y
  • Journal Title: Translational Medicine On line Volume: 2161-1025-S2-004
  • NAID: 40020083451
  • Peer Reviewed
• [Journal Article] Rebamipide ameliorates indomethacin-induced small intestinal injury in rats via the inhibition of matrix metalloproteinases activity (2012)
  • Author(s): Yamada S, Naito Y, Takagi T, Mizushima K, Horie R, Fukumoto K, Inoue K, Harusato A, Uchiyama K, Handa O, Yagi N, Ichikawa H, Yoshikawa T
  • Journal Title: J Gastroenterol Hepatol Volume: 27 Pages: 1816-24
  • Peer Reviewed
• [Journal Article] Partially hydrolyzed guar gum affects the expression of genes involved in host defense functions and cholesterol absorption in colonic mucosa of db/db male mice (2012)
  • Author(s): J Gastroenterol Hepatol
  • Journal Title: J Clin Biochem Nutr Volume: 51 Pages: 33-8
  • Peer Reviewed
• [Journal Article] Yoshida N, Naito Y, Inada Y, Kugai M, Inoue K, Uchiyama K, Handa O, Takagi T,Konishi H, Yagi N, Morimoto Y, Wakabayashi N, Yanagisawa A, Yoshikawa T (2012)
  • Author(s): Yoshida N, Naito Y, Inada Y, Kugai M, Inoue K, Uchiyama K, Handa O, Takagi T,Konishi H, Yagi N, Morimoto Y, Wakabayashi N, Yanagisawa A, Yoshikawa T
  • Journal Title: Int J Colorectal Dis Volume: 27 Pages: 605-11
  • Peer Reviewed
• [Journal Article] Endoscopic mucosal resection with 0.13% hyaluronic acid solution for colorectal polyps less than 20 mm: A randomized controlled trial (2012)
  • Author(s): Yoshida N, Naito Y, Inada Y, Kugai M, Kamada K, Katada K, Uchiyama K, Ishikawa T, Takagi T, Handa O, Konishi H, Yagi N, Kokura S, Wakabayashi N, Yanagisawa A, Yoshikawa T
  • Journal Title: J Gastroenterol Hepatol
  • Peer Reviewed
• [Journal Article] Multicenter study of endoscopic mucosal resection using 0.13 % hyaluronic acid solution of colorectal polyps less than 20 mm in siz (2012)
  • Author(s): Yoshida N, Naito Y, Inada Y, Kugai M, Yagi N, Inoue K, Okuda T, Hasegawa D, Kanemasa K, Kyoichi K, Matsuyama K,Ando T, Takemura T, Shimizu S, Wakabayashi N, Yanagisawa A, Yoshikawa T
  • Journal Title: Int J Colorectal Dis
  • Peer Reviewed
• [Journal Article] Importance of histological evaluation in endoscopic resection of early colorectal cancer (2012)
  • Author(s): Yoshida N, Naito Y, Yagi N, Yanagisawa A
  • Journal Title: World J Gastrointest Pathophysiol Volume: 3 Pages: 51-9
  • Peer Reviewed
• [Journal Article] Rebamipide ameliorates indomethacin-induced small intestinal injury in rats via the inhibition of matrix metalloproteinases activity (2012)
  • Author(s): Yamada, S. Naito, Y. Takagi, T. Mizushima, K. Horie, R. Fukumoto, K. Inoue, K. Harusato, A. Uchiyama, K. Handa, O. Yagi, N. Ichikawa, H. Yoshikawa, T.
  • Journal Title: J Gastroenterol Hepatol Volume: 27 Issue: 12 Pages: 1816-1824
  • DOI: 10.1111/j.1440-1746.2012.07275.x
  • Peer Reviewed
• [Journal Article] Colonic insufflation with carbon monoxide gas inhibits the development of intestinal inflammation in rats (2012)
  • Author(s): Takagi, T. Naito, Y. Uchiyama, K. Okuda, T. Suzuki, T. Tsuboi, H. Mizushima, K. Handa, O. Yagi, N. Ichikawa, H. Yoshikawa, T.
  • Journal Title: Med Gas Res Volume: 2 Issue: 1 Pages: 23-23
  • DOI: 10.1186/2045-9912-2-23
  • Peer Reviewed
• [Journal Article] A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise (2012)
  • Author(s): Aoi, W. Naito, Y. Takagi, T. Tanimura, Y. Takanami, Y. Kawai, Y. Sakuma, K. Hang, L. P. Mizushima, K. Hirai, Y. Koyama, R. Wada, S. Higashi, A. Kokura, S. Ichikawa, H. Yoshikawa, T.
  • Journal Title: Gut Volume: E-pub Issue: 6 Pages: 882-9
  • DOI: 10.1136/gutjnl-2011-300776
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• [Journal Article] Regular exercise prevents high-sucrose diet-induced fatty liver via improvement of hepatic lipid metabolism (2011)
  • Author(s): Aoi W, Naito Y, Hang LP, Uchiyama K, Akagiri S, Mizushima K, Yoshikawa T
  • Journal Title: Biochem Biophys Res Commun Volume: 413 Pages: 330-5
  • Peer Reviewed
• [Journal Article] Dietary exercise as a novel strategy for the prevention and treatment of metabolic syndrome: effects on skeletal muscle function (2011)
  • Author(s): Aoi W, Naito Y, Yoshikawa T
  • Journal Title: J Nutr Metab Volume: 2011 Pages: 676208-676208
  • Peer Reviewed
• [Journal Article] Dietary whey hydrolysate with exercise alters the plasma protein profile: a comprehensive protein analysis (2011)
  • Author(s): Aoi W, Takanami Y, Kawai Y, Morifuji M, Koga J, Kanegae M, Mihara K, Yanohara T, Mukai J, Naito Y, Yoshikawa T
  • Journal Title: Nutrition Volume: 27 Pages: 687-92
  • Peer Reviewed
• [Journal Article] Suppression of indomethacin-induced apoptosis in the small intestine due to Bach1 deficiency (2011)
  • Author(s): Harusato A, Naito Y, Takagi T, Uchiyama K, Mizushima K, Hirai Y, Yamada S, Tuji T, Yoriki H, Horie R, Inoue K, Fukumoto K, Handa O, Ishikawa T, Kokura S, Minamiyama Y, Ichikawa H, Muto A, Igarashi K, Yoshikawa T
  • Journal Title: Free Radic Res Volume: 45 Pages: 717-27
  • Peer Reviewed
• [Journal Article] Endogenous hydrogen sulfide is an anti-inflammatory molecule in dextran sodium sulfate-induced colitis in mice (2011)
  • Author(s): Hirata I, Naito Y, Takagi T, Mizushima K, Suzuki T, Omatsu T, Handa O, Ichikawa H, Ueda H, Yoshikawa T
  • Journal Title: Dig Dis Sci Volume: 56 Pages: 1379-86
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• [Journal Article] Daikenchuto, a kampo medicine, regulates intestinal fibrosis associated with decreasing expression of heat shock protein 47 and collagen content in a rat colitis model (2011)
  • Author(s): Inoue K, Naito Y, Takagi T, Hayashi N, Hirai Y, Mizushima K, Horie R, Fukumoto K, Yamada S, Harusato A, Hirata I, Omatsu T, Yoshida N, Uchiyama K, Ishikawa T, Handa O, Konishi H, Wakabayashi N, Yagi N, Ichikawa H, Kokura S, Yoshikawa T
  • Journal Title: Biol Pharm Bull Volume: 34 Pages: 1659-65
  • NAID: 130001252846
  • Peer Reviewed
• [Journal Article] Oxidative stress-induced posttranslational modification of TRPV1 expressed in esophageal epithelial cells (2011)
  • Author(s): Kishimoto E, Naito Y, Handa O, Okada H, Mizushima K, Hirai Y, Nakabe N, Uchiyama K, Ishikawa T, Takagi T, Yagi N, Kokura S, Yoshida N, Yoshikawa T
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 301
  • Peer Reviewed
• [Journal Article] Gastric peroxisome proliferator activator receptor-gamma expression and cytoprotective actions of its ligands against ischemia-reperfusion injury in rats (2011)
  • Author(s): Naito Y, Takagi T, Katada K, Tomatsuri N, Mizushima K, Handa O, Kokura S, Yagi N, Ichikawa H, Yoshikawa T
  • Journal Title: J Clin Biochem Nutr Volume: 48 Pages: 170-7
  • NAID: 130004466634
  • Peer Reviewed
• [Journal Article] Heme oxygenase-1: a novel therapeutic target for gastrointestinal diseases (2011)
  • Author(s): Naito Y, Takagi T, Uchiyama K, Yoshikawa T
  • Journal Title: J Clin Biochem Nutr Volume: 48 Pages: 126-33
  • NAID: 130004466629
  • Peer Reviewed
• [Journal Article] Heat-shock protein 27 (Hsp27) as a target of methylglyoxal in gastrointestinal cancer (2011)
  • Author(s): Oya-Ito T, Naito Y, Takagi T, Handa O, Matsui H, Yamada M, Shima K, Yoshikawa T
  • Journal Title: Biochim Biophys Acta Volume: 1812 Pages: 769-81
  • Peer Reviewed
• [Journal Article] Heat shock protein 70-dependent protective effect of polaprezinc on acetylsalicylic acid-induced apoptosis of rat intestinal epithelial cells (2011)
  • Author(s): Qin Y, Naito Y, Handa O, Hayashi N, Kuki A, Mizushima K, Omatsu T, Tanimura Y, Morita M, Adachi S, Fukui A, Hirata I, Kishimoto E, Nishikawa T, Uchiyama K, Ishikawa T, Takagi T, Yagi N, Kokura S, Yoshikawa T
  • Journal Title: J Clin Biochem Nutr Volume: 49 Pages: 174-81
  • NAID: 130004466658
  • Peer Reviewed
• [Journal Article] Identification of dihalogenated proteins in rat intestinal mucosa injured by indomethacin (2011)
  • Author(s): Takagi T, Naito Y, Okada H, Okayama T, Mizushima K, Yamada S, Fukumoto K, Inoue K, Takaoka M, Oya-Ito T, Uchiyama K, Ishikawa T, Handa O, Kokura S, Yagi N, Ichikawa H, Kato Y, Osawa T, Yoshikawa T.
  • Journal Title: J Clin Biochem Nutr Volume: 48 Pages: 178-82
  • NAID: 130004466635
  • Peer Reviewed
• [Journal Article] Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution (2011)
  • Author(s): Takagi T, Naito Y, Uchiyama K, Okuda T, Mizushima K, Suzuki T, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Yoshikawa T
  • Journal Title: World J Gastroenterol Volume: 17 Pages: 3802-9
  • Peer Reviewed
• [Journal Article] Carbon monoxide liberated from carbon monoxide-releasing molecule exerts an anti-inflammatory effect on dextran sulfate sodium-induced colitis in mice (2011)
  • Author(s): Takagi T, Naito Y, Uchiyama K, Suzuki T, Hirata I, Mizushima K, Tsuboi H, Hayashi N, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Yoshikawa T
  • Journal Title: Dig Dis Sci Volume: 56 Pages: 1663-71
  • Peer Reviewed
• [Journal Article] Multifaceted Assessment of Chronic Gastritis: A Study of Correlations between Serological, Endoscopic, and Histological Diagnostics (2011)
  • Author(s): Takao T, Ishikawa T, Ando T, Takao M, Matsumoto T, Isozaki Y, Okita M, Nagao Y, Oyamada H, Yokoyama K, Tatebe A, Uchiyama K, Handa O, Takagi T, Yagi N, Kokura S, Naito Y, Yoshikawa T
  • Journal Title: astroenterol Res Pract Volume: 2011 Pages: 6314-6314
  • Peer Reviewed
• [Journal Article] FGF19 protects colonic epithelial cells against hydrogen peroxide (2011)
  • Author(s): Uchiyama K, Naito Y, Takagi T, Mizushima K, Hayashi N, Handa O, Ishikawa T, Yagi N, Kokura S, Yoshikawa T
  • Journal Title: Digestion Volume: 83 Pages: 180-3
  • Peer Reviewed
• [Journal Article] Reduced small-intestinal injury induced by indomethacin in interleukin-17A-deficient mice (2011)
  • Author(s): Yamada S, Naito Y, Takagi T, Mizushima K, Hirai Y, Horie R, Fukumoto K, Inoue K, Harusato A, Yoshida N, Uchiyama K, Handa O, Ishikawa T, Konishi H, Wakabayashi N, Yagi N, Kokura S, Kita M, Yoshikawa T
  • Journal Title: J Gastroenterol Hepatol Volume: 26 Pages: 398-404
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• [Journal Article] Efficacy of magnifying endoscopy with flexible spectral imaging color enhancement in the diagnosis of colorectal tumors (2011)
  • Author(s): Yoshida N, Naito Y, Kugai M, Inoue K, Uchiyama K, Takagi T, Ishikawa T, Handa O, Konishi H, Wakabayashi N, Kokura S, Yagi N, Morimoto Y, Yanagisawa A, Yoshikawa T.
  • Journal Title: J Gastroenterol Volume: 46 Pages: 65-72
  • NAID: 10029026634
  • Peer Reviewed
• [Journal Article] Efficacy of hyaluronic acid in endoscopic mucosal resection of colorectal tumors (2011)
  • Author(s): Yoshida N, Naito Y, Kugai M, Inoue K, Uchiyama K, Takagi T, Ishikawa T, Handa O, Konishi H, Wakabayashi N, Yagi N, Kokura S, Morimoto Y, Kanemasa K, Yanagisawa A, Yoshikawa T
  • Journal Title: J Gastroenterol Hepatol Volume: 26 Pages: 286-91
  • Peer Reviewed
• [Journal Article] Heat-shock protein 27(Hsp27) as a target of methylglyoxal in gastrointestinal cancer (2011)
  • Author(s): Oya-Ito T, Naito Y, Takagi T, Handa O, Matsui H, Yamada M, Shima K, Yoshikawa T
  • Journal Title: Biochim Biophys Acta Volume: 1812 Issue: 7 Pages: 769-81
  • DOI: 10.1016/j.bbadis.2011.03.017
  • Peer Reviewed
• [Journal Article] FGF19 protects colonic epithelial cells against hydrogen peroxide (2011)
  • Author(s): Uchiyama K, Naito Y, Takagi T, Mizushima K, Hayashi N, Handa O, Ishikawa T, Yagi N, Kokura S, Yoshikawa T
  • Journal Title: Digestion Volume: 83 Issue: 3 Pages: 180-3
  • DOI: 10.1159/000321809
  • Peer Reviewed
• [Journal Article] The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity (2010)
  • Author(s): Aoi W, Naito Y, Mizushima K, Takanami Y, Kawai Y, Ichikawa H, Yoshikawa T
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 298
  • Peer Reviewed
• [Journal Article] Regular exercise reduces colon tumorigenesis associated with suppression of iNOS (2010)
  • Author(s): Aoi W, Naito Y, Takagi T, Kokura S, Mizushima K, Takanami Y, Kawai Y,Tanimura Y, Hung LP, Koyama R, Ichikawa H, Yoshikawa T.
  • Journal Title: Biochem Biophys Res Commun Volume: 399 Pages: 14-19
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• [Journal Article] Chemical and immunochemical detection of 8-halogenated deoxyguanosines at early stage inflammation (2010)
  • Author(s): Asahi T, Kondo H, Masuda M, Nishino H, Aratani Y, Naito Y, Yoshikawa T, Hisaka S, Kato Y, Osawa T
  • Journal Title: J Biol Chem Volume: 285 Pages: 9282-91
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• [Journal Article] Identification of inflammation-related proteins in a murine colitis model by 2D fluorescence difference gel electrophoresis and mass spectrometry (2010)
  • Author(s): Naito Y, Takagi T, Okada H, Omatsu T, Mizushima K, Handa O, Kokura S, Ichikawa H, Fujiwake H, Yoshikawa T
  • Journal Title: J Gastroenterol Hepatol Volume: 25 Suppl 1
  • Peer Reviewed
• [Journal Article] Gastrointestinal cytoprotection by PPAR・ligands (2010)
  • Author(s): Naito Y, Takagi T, Yoshikawa T
  • Journal Title: PPAR Research Volume: 2010 Pages: 1-8
  • DOI: 10.1155/2010/108632
  • Peer Reviewed
• [Journal Article] Lansoprazole, a proton pump inhibitor, to reduce gastrointestinal inflammation via heme oxygenase-1 induction (2010)
  • Author(s): Naito Y, Takagi T, Yoshikawa T
  • Journal Title: Molecular Cellular Pharmacol Volume: 2 Pages: 53-60
  • Peer Reviewed
• [Journal Article] Rebamipide: a gastrointestinal protective drug with pleiotropic activities (2010)
  • Author(s): Naito Y, Yoshikawa T
  • Journal Title: Expert Rev Gastroenterol Hepatol Volume: 4 Pages: 261-70
  • Peer Reviewed
• [Journal Article] Reactive oxygen species-quenching and anti-apoptotic effect of polaprezinc on indomethacin-induced small intestinal epithelial cell injury (2010)
  • Author(s): Omatsu T, Naito Y, Handa O, Mizushima K, Hayashi N, Qin Y, Harusato A, Hirata I, Kishimoto E, Okada H, Uchiyama K, Ishikawa T, Takagi T, Yagi N, Kokura S, Ichikawa H, Yoshikawa T
  • Journal Title: J Gastroenterol Volume: 45 Pages: 692-702
  • NAID: 10026706864
  • Peer Reviewed
• [Journal Article] Increased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis (2010)
  • Author(s): Takagi T, Naito Y, Mizushima K, Hirata I, Yagi N, Tomatsuri N, Ando T, Oyamada Y,Isozaki Y, Hongo H, Uchiyama K, Handa O, Kokura S, Ichikawa H, Yoshikawa T
  • Journal Title: J Gastroenterol Hepatol Volume: 25 Suppl 1
  • Peer Reviewed
• [Journal Article] Ecabet sodium promotes the healing of trinitrobenzene-sulfonic-acid-induced ulceration by enhanced restitution of intestinal epithelial cells (2010)
  • Author(s): Takagi T, Naito Y, Okuda T, Uchiyama K, Adachi S, Mizushima K, Handa O, Kokura S, Ichikawa H, Yoshikawa T
  • Journal Title: J Gastroenterol Hepatol Volume: 25 Pages: 1259-65
  • Peer Reviewed
• [Journal Article] The role of heme oxygenase and carbon monoxide in inflammatory bowel disease (2010)
  • Author(s): Takagi T, Naito Y, Uchiyama K, Yoshikawa T
  • Journal Title: Redox Rep Volume: 15 Pages: 193-201
  • Peer Reviewed
• [Journal Article] Carbon monoxide enhance colonic epithelial restitution via FGF15 derived from colonic myofibroblasts (2010)
  • Author(s): Uchiyama K, Naito Y, Takagi T, Mizushima K, Hayashi N, Harusato A, Hirata I, Omatsu T, Handa O, Ishikawa T, Yagi N, Kokura S, Yoshikawa T
  • Journal Title: Biochem Biophys Res Commun Volume: 391 Pages: 1122-1126
  • Peer Reviewed
• [Presentation] ベーシックサイエンスシンポジウム「細胞ストレスと代謝応答:生活習慣病への取り組み」消化管における酸化ストレス応答と Peroxiredoxin-6 (2012)
  • Author(s): 内藤裕二, 高木智久,伊藤(大矢)友子,吉川敏一
  • Organizer: 第12回日本抗加齢医学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-23
• [Presentation] シンポジウム「老い木に花咲く～見た目の老化に対する内的制御」消化管は全身の司令塔～Mirobiome から GLP-1 まで～ (2012)
  • Author(s): 内藤裕二,吉川敏一
  • Organizer: 第12回日本抗加齢医学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-22
• [Presentation] ミニシンポジウム「Neutraceutical をめぐって」消化管炎症抑制ヘムオキシゲナーゼを標的にした機能性食品成分 (2012)
  • Author(s): 内藤裕二, 高木智久,吉川敏一
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-19
• [Presentation] Invited Plenary Lecture. Hsp27, a new molecular target for the prevention of GI cancer (2012)
  • Author(s): Naito Y
  • Organizer: Gachon International Symposium on Gastroenterology 2012
  • Place of Presentation: Incheon
  • Year and Date: 2012-03-31
• [Presentation] シンポジウム「酸化ストレス研究-新しいバイオマーカーを求めて」消化管粘膜における Peroxiredoxin-6 の役割 (2012)
  • Author(s): 内藤裕二、 高木智久、吉川敏一
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-25
• [Presentation] Inivited Lecture : Pleiotropic Effects of Exercise and Food Factors on Life-style Related Diseases. 2011.11.21 ; Taipei (2011)
  • Author(s): Naito Y
  • Organizer: 2011 International Conference on Food Factors
  • Place of Presentation: Taipei
  • Year and Date: 2011-11-21
• [Presentation] シンポジウム「何をどう食べるかの科学」運動と食品因子による大腸癌予防 (2011)
  • Author(s): 内藤裕二,青井 渉,吉川敏一
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2011-05-27
• [Presentation] シンポジウム「消化器疾患と微小循環・酸化ストレス」翻訳後修飾タンパク質の解析で見えてきた酸化ストレス研究の新展開 (2011)
  • Author(s): 内藤裕二, 高木智久,吉川敏一
  • Organizer: 第97回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-13
• [Presentation] シンポジウム「酸化ストレス研究-臨床から基礎まで」翻訳後修飾タンパク質の解析で見えてきた酸化ストレス研究の新展開 (2011)
  • Author(s): 内藤裕二, 高木智久,吉川敏一
  • Organizer: 第81回日本衛生医学会
  • Place of Presentation: 東京(東日本大震災のため誌上発表)
  • Year and Date: 2011-03-27
• [Presentation] ネルディスカッション「大腸がん研究の新たな展開と治療戦略」運動による大腸腫瘍抑制作用は Secreted protein acidic and rich cystein(SPARC)を介する (2010)
  • Author(s): 内藤裕二, 高木智久,吉川敏一
  • Organizer: 第80回日本消化器内視鏡 学会総会(JDDW2010)
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-15
• [Presentation] ワークショップ「薬剤性小腸病変を巡って-現状と対策」OGIB 症例における服薬内容と小腸内視鏡所見の検討 (2010)
  • Author(s): 内藤裕二,半田 修,若林直樹
  • Organizer: 80回日本消化器内視鏡学会総会(JDDW2010)
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-15
• [Presentation] New molecular targets for gastric carcinogenesis determined by proteomics (2010)
  • Author(s): Naito Y, Ito-Oya T, Okada H, Takagi T, Handa O, Yoshikawa T
  • Organizer: Gachon International Gastric Cancer Symposium 2010
  • Place of Presentation: Incheon, Korea
  • Year and Date: 2010-10-09
• [Presentation] シンポジウム「抗酸化食品因子の新規な機能探索とその応用」蛋白質の酸化特異的修飾解析による機能性食品有効性評価標的分子の探索 (2010)
  • Author(s): 内藤裕二,半田 修,青井 渉,高橋二郎,吉川敏一
  • Organizer: 第63回日本酸化ストレス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-06-25
• [Presentation] 日常的運動による大腸癌予防:新規マイオカイン secreted protein acidic and rich in cysteine(SPARC)の発見とその意義
  • Author(s): 内藤裕二，髙木智久，青井 渉
  • Organizer: 第99回日本消化器病学会総会
  • Place of Presentation: 鹿児島
• [Presentation] Allele 解析をもとにした SLC38A9 の遺伝子多型と炎症性腸疾患の治療における azathioprine の薬物代謝に関する検討
  • Author(s): 内山和彦，髙木智久，内藤裕二
  • Organizer: 第99回日本消化器病学会総会
  • Place of Presentation: 鹿児島
• [Presentation] 炎症性腸疾患とヘムオキシゲナーゼ１
  • Author(s): 内藤裕二，高木智久
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
• [Presentation] 大腸癌予防と熱ショックタンパク質
  • Author(s): 内藤裕二
  • Organizer: 第７回臨床ストレス応答学会大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 消化管における酸化ストレス応答とPeroxiredoxin-6
  • Author(s): 内藤裕二，髙木智久，伊藤（大矢）友子，吉川敏一
  • Organizer: 第12回日本抗加齢医学会総会
  • Place of Presentation: 横浜
• [Remarks]
  • URL: http://www.f.kpu-m.ac.jp/k/sun/
• [Remarks]
  • URL: http://www.kpu-m.ac.jp/k/sun/
• [Remarks]
  • URL: http://www.kpu-m.ac.jp/k/sun/