Detection of methylglyoxal-modified Hsp27 and its role of colon carcinogenesis
Project/Area Number |
22590705
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
NAITO Yuji 京都府立医科大学, 医学(系)研究科, 准教授 (00305575)
|
Co-Investigator(Kenkyū-buntansha) |
TAKAGI Tomohisa 京都府立医科大学, 医学(系)研究科, 講師 (70405257)
ITO Tomoko (OYA Tomoko) 京都府立医科大学, 医学(系)研究科, 准教授 (80329648)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 大腸癌 / 熱ショックタンパク質 / メチルグリオキザール / 翻訳後修飾 / アポトーシス / 運動療法 / 熱ショック蛋白質27 |
Research Abstract |
Methylglyoxal (MG) is a reactive dicarbonyl compound produced from cellular glycolytic intermediates that reacts non-enzymatically with proteins. We found that heat shock protein 27 (Hsp27) was modified by MG in patients with cancers of ascending colon and rectum, but in non-cancerous cell lines or in normal subject. MG modification of Hsp27 protected the cells against apoptotic signaling. Our results suggest that posttranslational modification of Hsp27 by MG may have important implications for colon carcinogenesis.
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Report
(4 results)
Research Products
(79 results)
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