| Project/Area Number |
22590706
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TAKAGI Tomohisa 京都府立医科大学, 医学(系)研究科(研究院), 講師 (70405257)
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| Co-Investigator(Kenkyū-buntansha) |
NAITO Yuji 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (00305575)
半田 修 京都府立医科大学, 医学(系)研究科(研究院), 講師 (90381970)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 一酸化炭素 / 潰瘍性大腸炎 / クローン病 / 炎症性腸疾患 / 抗炎症作用 / 粘膜治癒 / Trinitrobenzesulfonic acid / TNF-alpha / CINC-1 |
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| Research Abstract |
An abundance of recent data on the cytoprotective and anti-inflammatory effect of carbon monoxide (CO) supports that CO is a promising therapeutic gas for various diseases. In the present study, we investigated whether the enema with CO-saturated saline as a novel therapeutic strategy was effective against intestinal inflammation. CO-saturated solution was made by bubbled 50% CO gas into saline. In results, the intrarectal administration of CO-saturated solution ameliorated TNBS-induced colitis and accelerated the healing of the colonic ulceration. Moreover, CO-saturated medium enhanced the migration of intestinal epithelial cells. Thus, the rectal administration of CO-saturated solution protected from the intestinal inflammation and accelerated the colonic ulcer healing. B ased on these data, CO mayrepresent a novel therapeutic approach for the treatment of inflammatory bowel disease.
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