| Project/Area Number |
22590707
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
NAKAMICHI Ikuo 九州歯科大学, 総合内科学, 助教 (60419570)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Takayuki 九州大学, 大学院・医学研究院, 准教授 (10278955)
TAKATA Yutaka 九州歯科大学, 歯学部, 教授 (40163208)
ANSAI Toshihiro 九州歯科大学, 歯学部, 教授 (80244789)
黒田 雅彦 東京医科大学, 医学部, 教授 (80251304)
村上 善樹 京都大学, 医学研究科, 准教授 (00397556)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 下部消化管学(小腸、大腸) / miRNA / 炎症性腸疾患 / 血清診断学 / 核酸創薬 / microRNA / 血清診断 / トランスレーショナル / マイクロRNA / マイクロアレイ / 発現制御 |
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| Research Abstract |
We measured serum miRNA before and after the antiTNF alpha antibody administration that was standard molecular target therapy of the Crohn's disease. As a result, showed a change in 12 miRNAs. Also, in the comparison between remission group and non-remission group, we confirmed that let-7d and let-7e were increased in a remission group. The molecular biologic significance of serum let-7 should be examined. It may be involved in apoptosis of T lymphocytes causing inflammation. As a result, let-7 may become a therapeutic marker of the refractory Crohn's disease.
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