| Project/Area Number |
22590718
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KONDO Yuuji 東京大学, 医学部附属病院, 助教 (00572231)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
吉田 晴彦 東京大学, 医学部附属病院, 講師 (60240305)
大塚 基之 東京大学, 医学部附属病院, 助教 (90518945)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
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| Keywords | 肝臓学 / microRNA / 分化 / 肝細胞 / 肝癌 / AFP / microRNA122 / 癌幹細胞 / 肝細胞癌 |
|---|
| Research Abstract |
Liver specific miR122 is frequently downregulated in hepatocellular carcinoma (HCC). Knockdown of miR122 induces AFP expression, indicating the de-differentiation of hepatocytes. Decreased miR122 expression leads to the increased expression of CUX1, a transcriptional factor, which is related with the aggressiveness of HCC. From these results, decreased miR122 results in the AFP expression and aggressiveness of HCC, which is a molecular explanation about the clinical poor prognosis of HCCs with high AFP expression.
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