| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Hepatic sinusoid is composed of stellate cells (HSCs) and sinusoidalendothelial cells. In this study, we focused on cell-cell interaction between HSCs and theother non-parenchymal cells (NPCs) at liver fibrosis. We found that Oncostatin M (OSM)directly induced TIMP-1 expression in HSCs and contributed to liver fibrosis bysuppressing the digestion of collagen fiber. Furthermore, OSM seemed to induce theactivation of HSCs indirectly via NPCs. Finally, overexpression of OSM in liver resulted infibrosis without apparent hepatic injury.
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