Role of hepatic innate lymphocytes at the liver injury

• Project/Area Number: 22590721
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Niigata University
• Principal Investigator: ABO Toru 新潟大学, 医歯学系, 教授 (30005079)
• Co-Investigator(Kenkyū-buntansha): KAWAMURA Toshihiko 新潟大学, 医歯学系, 准教授 (70301182) ; KAWAMURA Hiroki 新潟大学, 医歯学系, 講師 (20333495) ; KANDA Yasuhiro 新潟大学, 医歯学系, 助教 (00436768)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 肝臓 / 自己免疫性肝炎 / 自然リンパ球 / 肝障害 / NKT細胞 / NK細胞 / 細胞傷害 / 肉芽腫 / リンパ球 / 自然免疫 / 自己抗体 / 胸腺外分化T細胞 / B細胞 / 自己免疫性疾患

Research Abstract

We analyzed the activation of the natural lymphocytes and the function of the hepatic lymphocyte on hepatitis. We found that hepatic NK cells activated strongly than other NK cells. This finding indicated hepatic natural lymphocytes had unique immunoresponses. In α-galactocylceramide-mediated hepatic injury, NKT cell promoted B-1 cell activation and autoantibody production. NKT cells also suppressed zymosan A-mediated granuloma formation in the liver.

Research Products

• [Journal Article] Biology of autoreactive extrathymic T cells and B-1 cells of the innate immune system (2012)
  • Author(s): Abo T, Tomiyama C, Watanabe H
  • Journal Title: Immunol Res Volume: 52 Issue: 3 Pages: 224-230
  • DOI: 10.1007/s12026-012-8324-4
  • Peer Reviewed
• [Journal Article] Natural killer T cells suppress zymosan A-mediated granuloma formation in the liver by modulating interferon-γ and interleukin-10 (2012)
  • Author(s): Kobayashi T, Kawamura H, Kanda Y, Matsumoto H, Saito S, Takeda K, Kawamura T, Abo T
  • Journal Title: Immunology Volume: 136 Issue: 1 Pages: 86-95
  • DOI: 10.1111/j.1365-2567.2012.03562.x
  • Peer Reviewed
• [Journal Article] Extracellular ATP-stimulated macrophages produce macrophage inflammatory protein-2 which is important for neutrophil migration. (2012)
  • Author(s): Hiroki Kawamura
  • Journal Title: Immunology Volume: 136 Issue: 4 Pages: 448-458
  • DOI: 10.1111/j.1365-2567.2012.03601.x
  • Peer Reviewed
• [Journal Article] Coincidence of autoantibody production with the activation of natural killer T cells inα-galactosylceramide-mediatedhepatic injury (2011)
  • Author(s): Matsumoto H, Kawamura T, Kobayashi T, Kanda Y, Kawamura H, Abo T
  • Journal Title: Immunology Volume: 133 Issue: 1 Pages: 21-28
  • DOI: 10.1111/j.1365-2567.2011.03405.x
  • Peer Reviewed
• [Journal Article] Suppressive role of hepatic dendritic cells in concanayalin A-induced hepatitis (2011)
  • Author(s): 富山智香子, 他
  • Journal Title: Clin Exp Immunol Volume: 116 Issue: 2 Pages: 258-268
  • DOI: 10.1111/j.1365-2249.2011.04458.x
  • Peer Reviewed
• [Journal Article] Coincidence of autoantibody production with the activation of natural killer T cens in a-galactosyl ceramide-mediated hepatic injury (2011)
  • Author(s): 松本浩章, 他
  • Journal Title: Immunology Volume: 133 Pages: 21-28
  • Peer Reviewed
• [Journal Article] Identification and characterization of autoantibody-producing B220low B (B-1) cells appearing in malarial infection (2010)
  • Author(s): Kanda Y, Kawamura H, Matsumoto H, Kobayashi T, Kawamura T, Abo T
  • Journal Title: Cell Immunol Volume: 263 Issue: 1 Pages: 49-54
  • DOI: 10.1016/j.cellimm.2010.02.015
  • Peer Reviewed
• [Journal Article] Identification and characterization of autoantibody-producing B220^<low> B(B-1)cells appearing in malarial infection (2010)
  • Author(s): 神田泰洋, 他
  • Journal Title: Cellular lmmunology Volume: 263 Pages: 49-54
  • Peer Reviewed
• [Presentation] NKT cells suppress zymosan A-mediated granuloma formation in the liver by modulating IFNg andIL-10 (2012)
  • Author(s): Kobayashi T, Abo T
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-07
• [Presentation] Extracellular ATP-stimulated macrophages produce macrophage inflammatory protein-2 which is important for neutrophil migration (2012)
  • Author(s): Kawamura H, Abo T
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-05
• [Presentation] NKT cells suppress zymosan A-mediated granuloma formation in the liver by modulating IFNg and IL-10 (2012)
  • Author(s): Takahiro Kobayashi
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] Identification and characterization ofautoantibody-producing B220low cells appearing in malaria infection (2011)
  • Author(s): Kanda Y, Abo T
  • Organizer: 日本免疫学会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-27
• [Presentation] Coincidence of autoantibody production with the activation of natural killer T cells in alpha-galactosylceramide-mediated hepatic injury (2011)
  • Author(s): Matsumoto H, Abo T
  • Organizer: 日本免疫学会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-27
• [Presentation] Identification and characterization of autoantibody producing B220^<low> B (B-1) cells appearing in malarial infection (2011)
  • Author(s): 神田泰洋, 他
  • Organizer: 日本免疫学会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-27
• [Presentation] NKT cells downregulate Toll-like receptor2-mediated granuloma formation in the liver via modulation of IFNg and IL-10 (2011)
  • Author(s): 小林敬広, 他
  • Organizer: 日本免疫学会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-27
• [Presentation] α-galactosylceramide誘導性肝炎におけるNKT細胞の活性化と自己抗体産生 (2011)
  • Author(s): 松本浩章, 他
  • Organizer: 日本免疫学会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-27
• [Book] 安保徹の免疫学講義 (2010)
  • Author(s): 安保徹
  • Total Pages: 245
  • Publisher: 三和書籍
• [Book] 病態のしくみがわかる免疫学 (2010)
  • Author(s): 安保徹,他
  • Total Pages: 284
  • Publisher: 医学書院