Role of hepatic innate lymphocytes at the liver injury
| Project/Area Number |
22590721
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Niigata University |
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Principal Investigator |
ABO Toru 新潟大学, 医歯学系, 教授 (30005079)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMURA Toshihiko 新潟大学, 医歯学系, 准教授 (70301182)
KAWAMURA Hiroki 新潟大学, 医歯学系, 講師 (20333495)
KANDA Yasuhiro 新潟大学, 医歯学系, 助教 (00436768)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肝臓 / 自己免疫性肝炎 / 自然リンパ球 / 肝障害 / NKT細胞 / NK細胞 / 細胞傷害 / 肉芽腫 / リンパ球 / 自然免疫 / 自己抗体 / 胸腺外分化T細胞 / B細胞 / 自己免疫性疾患 |
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| Research Abstract |
We analyzed the activation of the natural lymphocytes and the function of the hepatic lymphocyte on hepatitis. We found that hepatic NK cells activated strongly than other NK cells. This finding indicated hepatic natural lymphocytes had unique immunoresponses. In α-galactocylceramide-mediated hepatic injury, NKT cell promoted B-1 cell activation and autoantibody production. NKT cells also suppressed zymosan A-mediated granuloma formation in the liver.
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Report
(4 results)
Research Products
(18 results)
