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Comprehensive analysis of the relationship between gene polymorphisms and protein expression and pathology, therapeutic value and prognosis of autoimmune liver diseases.

Research Project

Project/Area Number 22590725
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionShinshu University

Principal Investigator

YOSHIZAWA Kaname  信州大学, 医学部, 特任教授 (90220615)

Co-Investigator(Kenkyū-buntansha) OTA Masao  信州大学, 医学部, 准教授 (50115333)
UMRMURA Takeji  信州大学, 医学部, 准教授 (30419345)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords自己免疫性肝炎 / 原発性胆汁性肝硬変 / 疾患感受性遺伝子 / 遺伝子多型 / ゲノムワイド解析 / サイトカイン / IgG4関連疾患
Research Abstract

The outcome of autoimmune hepatitis (AIH) over a long follow-up period compared with that of the general Japanese population as well as that among patients. Repeated relapses of AIH are significantly associated with a poorer long-term prognosis. AIH patients can expect a similar prognosis to that of the general population, provided that they are adequately managed with continuous low doses of immunosuppressive therapy, especially after the first relapse. A complex interplay of several cytokines, especially pro-inflammatory and Th17 cytokines and regulatory T cell suppression by IL-12p40 may play a pivotal role in the pathogenesis of AIH. The roles of HLA haplotypes and several gene polymorphisms in determining primary biliary cirrhosis susceptibility and progression were clarified by SNP analysis including genome -wide association study.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (57 results)

All 2013 2012 2011 2010 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (32 results) Book (2 results)

  • [Journal Article] Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis.2013

    • Author(s)
      Morita S, Joshita S, Umemura T, Katsuyama Y, Kimura T, Komatsu M, Matsumoto A, Yoshizawa K, Kamijo A, Yamamura N, Tanaka E, Ota M.
    • Journal Title

      Hum Immunol.

      Volume: 74 Pages: 219-22

    • NAID

      120007100710

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis.2013

    • Author(s)
      Morita S
    • Journal Title

      Hum Immunol

      Volume: 74 Issue: 2 Pages: 219-222

    • DOI

      10.1016/j.humimm.2012.10.022

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population2012

    • Author(s)
      Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, Nakamura H, Komori A, Nakamuta M, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Onji M, Kaneko S, Honda M, Yamagiwa S, Nakao K, Ichida T, Takikawa H, Seike M, Umemura T, Ueno Y, Sakisaka S, Kikuchi K, Ebinuma H, Yamashiki N, Tamura S, Sugawara Y, Mori A, Yagi S, Shirabe K, Taketomi A, Arai K, Monoe K, Ichikawa T, Taniai M, Miyake Y, Kumagi T, Abe M, Yoshizawa K, Joshita S, Shimoda S, Honda K, Takahashi H, Hirano K, Takeyama Y, Harada K, Migita K, Ito M, Yatsuhashi H, Fukushima N, Ota H, Komatsu T, Saoshiro T, Ishida J, Kouno H, Kouno H, Yagura M, Kobayashi M, Muro T, Masaki N, Hirata K, Watanabe Y, Nakamura Y, Shimada M, Hirashima N, Komeda T, Sugi K, Koga M, Ario K, Takesaki E, Maehara Y, Uemoto S, Kokudo N, Tsubouchi H, Mizokami M, Nakanuma Y, Tokunaga K, Ishibashi H.
    • Journal Title

      Am J Hum Genet.

      Volume: 91 Pages: 721-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of Japanese patients with type 1 autoimmune hepatitis.2012

    • Author(s)
      Yoshizawa K, Matsumoto A, Ichijo T, Umemura T, Joshita S, Komatsu M, Tanaka N, Tanaka E, Ota M, Katsuyama Y, Kiyosawa K, Abe M, Onji M.
    • Journal Title

      Hepatology.

      Volume: 56 Pages: 66876-66876

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis.2012

    • Author(s)
      Umemura T, Joshita S, Ichijo T, Yoshizawa K, Katsuyama Y, Tanaka E, Ota M; Shinshu PBC Study Group.
    • Journal Title

      Hepatology.

      Volume: 55 Pages: 506-11

    • NAID

      120007100712

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of Japanese patients with type 1 autoimmune hepatitis2012

    • Author(s)
      Yoshizawa K, Matsumoto A, Ichijo T, Umemura K, Joshita S, Komatsu M, Tanaka N, Tanaka E, Ota M, Katsuyama Y, Kiyosawa K, Abe M, Onji M
    • Journal Title

      Hepatology

      Volume: (in press) Issue: 2 Pages: 668-676

    • DOI

      10.1002/hep.25658

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.2012

    • Author(s)
      Nakamura M
    • Journal Title

      Am J Hum Genet.

      Volume: 91 Issue: 4 Pages: 721-728

    • DOI

      10.1016/j.ajhg.2012.08.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis2012

    • Author(s)
      Umemura K, Joshita S, Ichijo T, Yoshizawa K, Katsuyama Y, Tanaka E, Ota M
    • Journal Title

      Hepatology

      Volume: 55 Issue: 2 Pages: 506-511

    • DOI

      10.1002/hep.24705

    • NAID

      120007100712

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary biliary cirrhosis - Autoimmune hepatitis overlap syndrome: A rationale for corticosteroids use based on a nation-wide retrospective study in Japan.2011

    • Author(s)
      Tanaka A, Harada K, Ebinuma H, Komori A, Yokokawa J, Yoshizawa K, Abe M, Miyake Y, Kikuchi K, Ohira H, Zeniya M, Yamamoto K, Ishibashi H, Onji M, Nakanuma Y, Tsubouchi H, Takikawa H
    • Journal Title

      Hepatol Res.

      Volume: 41 Pages: 877-886

    • NAID

      10031144160

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphism in the KCNA3 gene is associated with susceptibility to autoimmune pancreatitis in the Japanese population.2011

    • Author(s)
      Ota M, Ito T, Umemura T, Katsuyama Y, Yoshizawa K, Hamano H, Kawa S.
    • Journal Title

      Dis Markers.

      Volume: 31 Pages: 223-9

    • NAID

      120007100596

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms in CTLA4 and SLC4A2 are differentially associated with the pathogenesis of primary biliary cirrhosis in Japanese patients.2011

    • Author(s)
      Aiba Y, Nakamura M, Joshita S, Inamine T, Komori A, Yoshizawa K, Umemura T, Horie H, Migita K, Yatsuhashi H, Nakamuta M, Fukushima N, Saoshiro T, Hayashi S, Kouno H, Ota H, Muro T, Watanabe Y, Nakamura Y, Komeda T, Shimada M, Masaki N, Komatsu T, Yagura M, Sugi K, Koga M, Tsukamoto K, Tanaka E, Ishibashi H
    • Journal Title

      J Gastroenterol.

      Volume: 46 Pages: 1203-12

    • NAID

      10030294477

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytokine profiles affecting the pathogenesis of autoimmune hepatitis in Japanese patients.2011

    • Author(s)
      Kamijo A, Yoshizawa K, Joshita S, Yoneda S, Umemura T, Ichijo T, Matsumoto A, Ota M, Tanaka E.
    • Journal Title

      Hepatol Res.

      Volume: 41 Pages: 350-7

    • NAID

      10031144099

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of immunoglobulin G4-associated autoimmune hepatitis.2011

    • Author(s)
      Umemura T, Zen Y, Hamano H, Joshita S, Ichijo T, Yoshizawa K, Kiyosawa K, Ota M, Kawa S, Nakanuma Y, Tanaka E.
    • Journal Title

      J Gastroenterol.

      Volume: 46 Pages: 48-55

    • NAID

      10029030266

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic background of autoimmune hepatitis in Japan.2011

    • Author(s)
      Yoshizawa K, Umemura T, Ota M.
    • Journal Title

      J Gastroenterol.

      Volume: 46 Suppl 1 Pages: 42-7

    • NAID

      10029030226

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytokine profiles affecting the pathogenesis of autoimmune hepatitis in Japanese patients2011

    • Author(s)
      Kamijo A, Yoshizawa K, Joshita S, Yoneda S, Umemura T, Ichijo T, Matsumoto A, Ota M, Tanaka E
    • Journal Title

      Hepatol Res

      Volume: 41 Issue: 4 Pages: 350-357

    • DOI

      10.1111/j.1872-034x.2011.00773.x

    • NAID

      10031144099

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary biliary cirrhosis - Autoimmune hepatitis overlap syndrome: A rationale for corticosteroids use based on a nation-wide retrospective study in Japan2011

    • Author(s)
      Tanaka A, Harada K, Ebinuma H, Komori A, Yokokawa J, Yoshizawa K, Abe M, Miyake Y, Kikuchi K, Ohira H, Zeniya M, Yamamoto K, Ishibashi H, Onji M, Nakanuma Y, Tsubouchi H, Takikawa H
    • Journal Title

      Hepatol Res

      Volume: 41 Issue: 9 Pages: 877

    • DOI

      10.1111/j.1872-034x.2011.00844.x

    • NAID

      10031144160

    • URL

      https://pure.teikyo.jp/en/publications/06ad5895-c408-4a92-aace-0086a2716019

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms in CTLA4 and SLC4A2 are differentially associated with the pathogenesis of primary biliary cirrhosis in Japanese patients2011

    • Author(s)
      Aiba Y, Nakamura M, Joshita S, Inamine T, Komori A, Yoshizawa K, 他24名
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 1203-1212

    • NAID

      10030294477

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic background of autoimmune hepatitis in Japan.2011

    • Author(s)
      Yoshizawa K, et al
    • Journal Title

      J Gastroenterol.

      Volume: 46 suppl. Pages: 42-47

    • NAID

      10029030226

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of immunoglobulin G4-associated autoimmune hepatitis.2011

    • Author(s)
      Umemura T,..,,.,Yoshizawa K, et al
    • Journal Title

      J Gastroenterol.

      Volume: 46 suppl. Pages: 48-55

    • NAID

      10029030266

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients.2010

    • Author(s)
      Joshita S, Umemura T, Yoshizawa K,Katsuyama Y, Tanaka E, Ota M; Shinshu PBC Study Group.
    • Journal Title

      Hum Immuno l

      Volume: 71 Pages: 520-524

    • NAID

      120007110421

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association analysis of cytotoxic T -lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients.2010

    • Author(s)
      Joshita S, Umemura T, Yoshizawa K, Katsuyama Y, Tanaka E, Nakamura M, Ishibashi H, Ota M; The Shinshu PBC Study Group.
    • Journal Title

      J Hepatol.

      Volume: 53 Pages: 537-541

    • NAID

      120007110444

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients.2010

    • Author(s)
      Joshita S, Umemura T, Yoshi zawa K, et al
    • Journal Title

      Hum Immunol.

      Volume: 71 Pages: 520-524

    • NAID

      120007110421

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese pat ients.2010

    • Author(s)
      Joshita S, Umemura T, Yoshi zawa K, et al
    • Journal Title

      J Hepatol.

      Volume: 53 Pages: 537-541

    • NAID

      120007110444

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Signal transducer and activator of transcription 4 gene polymorphisms are associated with production of anti-nuclear antibody in Japanese patients with primary biliary cirrhosis.2012

    • Author(s)
      Joshita S, Umemura T, Nakamura M, Yoshizawa K, Katsuyama Y, Shibata S, Okuhara S, Nozawa Y , Kimura T, Morita S, Komatsu M, Matsumoto A, Tanaka E, Ota M.
    • Organizer
      アメリカ肝臓学 会 AASLD 2012
    • Place of Presentation
      Boston, USA
    • Year and Date
      2012-11-02
    • Related Report
      2012 Final Research Report
  • [Presentation] HLA DRB1*09:01-DQB1*03:03 Haplotype is associated with progression of Primary Biliary Cirrhosis.2012

    • Author(s)
      Umemura T, Joshita S, Katsuyama Y, Shibata S, Kimura T, Morita S, Komatsu M, Matsumoto A, Yoshizawa K, Tanaka E, Ota M
    • Organizer
      ア メリ カ肝臓学 会AASLD 2012
    • Place of Presentation
      Boston, USA
    • Year and Date
      2012-11-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 日本人原発性胆汁性肝硬変の病態形成に関与する HLA-A, -B, -DP, -DR 遺伝子多型と CTLA-4, SLC4A2, IL12A2012

    • Author(s)
      相葉 佳洋、安波道郎、小森敦正、右田清志、八橋 弘、中牟田誠、福嶋伸良、太田 肇、石田仁也、平田啓一、渡部幸夫、小松達司、矢倉道泰、高野弘嗣、室豊吉、島田昌明、米田俊貴、山下晴弘、竹崎英一、古賀満明、小林正和、杉 和洋、正木尚彦、吉澤 要、蒔田富士雄、高木 均、西村英夫、石橋大海、中村 稔
    • Organizer
      IRF5 遺伝子多型の検討 第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 日本人原発性胆汁性肝硬変のゲノムワイド解析2012

    • Author(s)
      中村 稔、西田奈央、川嶋実苗、田中 篤、中牟田誠、太田 肇、竿代丈夫、高野弘嗣、吉澤 要、小森敦正、梅村武司、銭谷幹男、恩地森一、橋本悦子、大平弘正、山本和秀、金子周一、山際 訓、中尾一彦、市田隆文、滝川 一、前原喜彦、上本伸一、国土典宏、坪内博仁、溝上雅史、徳永勝士、中沼安二、石橋大海
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 自己免疫性肝炎の長期予後2012

    • Author(s)
      吉澤 要、松本晶博、梅村武司、一條哲也、城下 智、小松通治、田中栄司、清澤研道、阿部雅則、恩地森一
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Association analysis of signal transducer and activator of transcription 4 gene polymorphisms with primary billiary cirrhosis in Japanese patients.2011

    • Author(s)
      Joshita S, Umemura T, Yoshizawa K,Katsuyama Y , Okuhara S, Ichikawa Y , Kimura T , Morita M, Komatsu M, Ichijo T , Matsumoto A, Ota M, TanakaE.
    • Organizer
      アメリカ肝臓学会AASLD 2011
    • Place of Presentation
      San FranciscoUSA
    • Year and Date
      2011-11-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Association analysis of signal transducer and activator of transcription 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients2011

    • Author(s)
      Joshita S, Ota M, Umemura T, Yoshizawa K, Katsuyama Y, Ichijo T, Tanaka E
    • Organizer
      AASLD
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 原発性胆汁性肝硬変における HLA の検討2011

    • Author(s)
      梅村武司、城下 智、 吉澤 要
    • Organizer
      JDDW 2011
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 原発性胆汁性肝硬変におけるHLAの検討(ワークショップ)2011

    • Author(s)
      梅村武司、城下智、吉澤要
    • Organizer
      第15回日本肝臓学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Association analysis of signal transducer and activator of transcription 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients2011

    • Author(s)
      Joshita S, Umemura T, Nakamura M, Yoshizawa K, Ota M, Ishibashi H, Tanaka E
    • Organizer
      APDW 2011
    • Place of Presentation
      Singapore
    • Year and Date
      2011-10-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Association analysis of cytotoxic T -lymphocyte antigen 4 gene polymorphisms with primary billiary cirrhosis, autoimmune hepatitis, and overlap syndrome in Japanese patients.2011

    • Author(s)
      Joshita S, Umemura T, Nakamura M, Yoshizawa K, Ota M, Ishibashi H, Tanaka E
    • Organizer
      アジア太平洋消化器病週間 APDW
    • Place of Presentation
      Singapore
    • Year and Date
      2011-10-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 長期経過からみた自己免疫性肝炎からの肝発癌2011

    • Author(s)
      吉澤 要、 松本晶博、一條哲也、城下智、木村岳史、市川雪、森田進、上條敦、小松通治、 梅村武司、田中榮司、 阿部雅則、恩地森一
    • Organizer
      第47回日本肝癌研究会
    • Place of Presentation
      静岡
    • Year and Date
      2011-07-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 長期経過からみた自己免疫性肝炎からの肝発癌(ワークショップ)2011

    • Author(s)
      吉澤要、松本晶博、一條哲也、城下智、木村岳史、市川雪、森田進、上條敦、小松通治、梅村武司、田中榮司、阿部雅則、恩地森一
    • Organizer
      第47回日本肝癌研究会
    • Place of Presentation
      静岡
    • Year and Date
      2011-07-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 自己免疫性肝炎の病態とサイトカインネットワーク(ワークショップ)2011

    • Author(s)
      吉澤要、城下智、梅村武司、上條敦、一條哲也、松本晶博、田中榮司
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 自己免疫性肝炎からの肝発癌の実態2010

    • Author(s)
      梅村武司、一條哲也、吉澤 要
    • Organizer
      第38回肝臓学会東部会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-03
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 自己免疫性肝炎におけるサイトカインの動向と病態との関連2010

    • Author(s)
      上條 敦、吉澤 要、城下 智、梅村武司、一條哲也、松本晶博、田中榮司
    • Organizer
      第38回肝臓学会東部会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-03
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Cytotoxic T -lymphocyte Antigen 4遺伝子多型と日本人の原発性胆汁性肝硬変発症に関する検討2010

    • Author(s)
      城下 智、 梅村武司、吉澤 要
    • Organizer
      第14回肝臓学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Cytotoxic T-lymphocyte Antigen 4遺伝子多型と日本人の原発性胆汁性肝硬変発症に関する検討2010

    • Author(s)
      城下智、梅村武司、吉澤要
    • Organizer
      第14回肝臓学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 自己免疫性肝炎の長期予後に及ぼす因子2010

    • Author(s)
      吉澤 要、松本晶博、一條哲也、梅村武司、城下 智、小松通治、上條 敦、米田 傑、森田 進、松本晶博、 田中榮司、清澤研道
    • Organizer
      第46回肝臓学会総会
    • Place of Presentation
      山形
    • Year and Date
      2010-05-27
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] ataxin2-binding protein 1 遺伝子多型は原発性胆汁性肝硬変の疾患感受性と相関する2010

    • Author(s)
      城下 智、 梅村武司、吉澤 要、森田 進、米田 傑、上條 敦、小松通治、一條哲也、松本晶博、 田中榮司
    • Organizer
      第46回肝臓学会総会
    • Place of Presentation
      山形
    • Year and Date
      2010-05-27
    • Related Report
      2012 Final Research Report
  • [Presentation] ataxin2-binding Protein1遺伝子多型は原発性胆汁性肝硬変の疾患感受性と相関する2010

    • Author(s)
      城下智、梅村武司、吉澤要, 他
    • Organizer
      第46回肝臓学会総会
    • Place of Presentation
      山形
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genetic background of autoimmune hepatitis in Japan.2010

    • Author(s)
      Yoshizawa K
    • Organizer
      日本消化器病学会 The 2ndInternational Forum
    • Place of Presentation
      Niigata
    • Year and Date
      2010-04-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Clinical significance of immunoglobulin G4-associated autoimmune hepatitis.2010

    • Author(s)
      Umemura T.
    • Organizer
      日本消化器病学会 The 2ndInternational Forum
    • Place of Presentation
      Niigata
    • Year and Date
      2010-04-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Genetic background of autoimmune hepatitis in Japan.2010

    • Author(s)
      Yoshizawa K, et al.
    • Organizer
      The 2^〈nd〉International Forum
    • Place of Presentation
      新潟
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Clinical significance of immunoglobulin G4-associated autoimmune hepatitis.2010

    • Author(s)
      Umemura T,...., Yoshizawa K, et al.
    • Organizer
      The 2^〈nd〉International Forum
    • Place of Presentation
      新潟
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ataxin 2-binding protein 1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients.2010

    • Author(s)
      Joshita S, Umemura T, Morita S, Kamijo A, Komatsu M, Ichijo T, Matsumoto A, Yoshizawa K, Tanaka E, Ota M.
    • Organizer
      ヨーロッパ肝臓学会 EASL
    • Place of Presentation
      Wien Austria
    • Year and Date
      2010-04-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients.2010

    • Author(s)
      Joshita S, Umemura T, Yos hizawa K, et al.
    • Organizer
      ヨーロッパ肝臓学会 EASL
    • Place of Presentation
      ウイーン
    • Year and Date
      2010-04-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Signal transducer and activator of transcription 4 gene polymorphisms are associated with production of anti-nuclear antibody in Japanese patients with primary biliary cirrhosis.

    • Author(s)
      Joshita S
    • Organizer
      AASLD 2012
    • Place of Presentation
      Boston
    • Related Report
      2012 Annual Research Report
  • [Presentation] HLA DRB1*09:01-DQB*03:03 haplotype is associated with progression of primary biliary cirrhosis.

    • Author(s)
      Umemura T
    • Organizer
      AASLD 2012
    • Place of Presentation
      Boston
    • Related Report
      2012 Annual Research Report
  • [Presentation] 自己免疫性肝炎の長期予後

    • Author(s)
      吉澤 要
    • Organizer
      日本肝臓学会総会
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report
  • [Presentation] 日本人原発性胆汁性肝硬変のゲノムワイド解析

    • Author(s)
      中村 稔
    • Organizer
      日本肝臓学会総会
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report
  • [Presentation] 日本人原発性胆汁性肝硬変の病態形成に関与するHLA-A, -B, -DP, -DR遺伝子多型とCTLA-4, SCLC4A2, IL12A, IRF5遺伝子多型の検討

    • Author(s)
      相葉佳洋
    • Organizer
      日本肝臓学会総会
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report
  • [Book] 肝疾患クリニカルスタンダード (自己免疫性肝炎他)2010

    • Author(s)
      吉澤 要 共著:編集 田中榮司他
    • Publisher
      文光堂
    • Related Report
      2012 Final Research Report
  • [Book] 肝疾患クリニカルスタンダード(自己免疫性肝炎他)2010

    • Author(s)
      吉澤要共著:編集田中榮司, 他
    • Publisher
      文光堂
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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