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The role of JNK signaling in the development of nonalcoholic steatohepatitis

Research Project

Project/Area Number 22590728
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKyoto University

Principal Investigator

KODAMA Yuzo  京都大学, 医学研究科, 助教 (80378687)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsNASH / 肝線維化 / JNK / 肝細胞癌
Research Abstract

Nonalcoholic steatohepatitis (NASH) is an important pathological condition responsible for liver fibrosis and cancer. In the current study, using NASH mouse model, we analyzed the role of JNK signaling in the development of NASH and subsequent formation of liver fibrosis and cancer. As a result, the development of liver fibrosis and cancer was reduced in jnk1knockout mice as compared to wild-type mice. Furthermore, analysis of chimeric mice generated by bone marrow transplantation or in vitro experiments using primary culture cells revealed the critical role of JNK1 in non-hematopoietic cells in the development of NASH.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 9 results)

  • [Journal Article] Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist2012

    • Author(s)
      Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y, Sirlin C, Yu E, Yu RT, Downes M, Evans RM, Brenner DA, Schnabl B
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 109 Issue: 21 Pages: 1369-76

    • DOI

      10.1073/pnas.1202464109

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase2011

    • Author(s)
      Brenner DA, Seki E, Taura K, Kisseleva T, Deminicis S, Iwaisako K, Inokuchi S, Schnabl B, Oesterreicher CH, Paik YH, Miura K, Kodama Y
    • Journal Title

      Hepatol Res

      Volume: 41 Pages: 683-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.2011

    • Author(s)
      Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M
    • Journal Title

      FASEB J

      Volume: 25 Issue: 4 Pages: 1133-44

    • DOI

      10.1096/fj.10-168351

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Non-alcoholic steatohepatitis-induced fibrosis : Toll-like receptors, reactive oxygen species and Jun N-terminal kinase2011

    • Author(s)
      Brenner DA, Seki E, Taura K, Kisseleva T, Deminicis S, Iwaisako K, Inokuchi S, Schnabl B, Oesterreicher CH, Paik YH, Miura K, Kodama Y
    • Journal Title

      Hepatology Research

      Volume: 41 Issue: 7 Pages: 683-686

    • DOI

      10.1111/j.1872-034x.2011.00814.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis2010

    • Author(s)
      De Minicis S, Seki E, Paik YH, Osterreicher CH, Kodama Y, Kluwe J, Torozzi L, Miyai K, Benedetti A, Schwabe RF, Brenner DA
    • Journal Title

      Hepatology

      Volume: 52 Issue: 4 Pages: 1420-30

    • DOI

      10.1002/hep.23804

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice2010

    • Author(s)
      Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, Olefsky JM, Brenner DA, Seki E
    • Journal Title

      Gastroenterology

      Volume: 139 Issue: 1 Pages: 323-34

    • DOI

      10.1053/j.gastro.2010.03.052

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis2010

    • Author(s)
      Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S, Brenner DA, Seki E
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 107 Issue: 2 Pages: 844-9

    • DOI

      10.1073/pnas.0909781107

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like Receptor 9 Promotes Steatohepatitis via Induction of Interleukin-1beta in Mice.2010

    • Author(s)
      Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, Olefsky JM, Brenner DA
    • Journal Title

      Gastroenterology

      Volume: 139 Pages: 323-334

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of TAK1 in Hepatocytes Causes Hepatic Injury, Inflammation, Fibrosis and Carcinogenesis.2010

    • Author(s)
      Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira s, Brenner DA, Seki E.
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: 107 Pages: 844-849

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed

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Published: 2010-08-23   Modified: 2019-07-29  

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