The regulation mechanism of adipose tissue in survival, proliferation, differentiation and migration of hepatocellular carcinoma-derived cancer stem cells
| Project/Area Number |
22590740
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Saga University |
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Principal Investigator |
NISHIJIMA Aki (MATSUNOBU Aki) 佐賀大学, 医学部, 医員 (40566105)
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| Co-Investigator(Kenkyū-buntansha) |
TODA Shuji 佐賀大学, 医学部, 教授 (80188755)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肝癌幹細胞 / 脂肪組織 / 癌幹細胞-間質細胞相互作用 / 癌幹細胞ー間質細胞相互作用 |
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| Research Abstract |
Adipose tissue inhibited the proliferation of hepatocellular carcinoma-derived cancer stem cells (CSCs) and did not affect apoptosis. The effect between subcutaneous and visceral adipose tissue about the migration is controversialimmunohistochemically, but there is no significant difference in the expression ofmigration-related molecules. Adipokine production levels differ between subcutaneous and visceral adipose tissue, but the production level is not different with or without CSCs.
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Report
(4 results)
Research Products
(23 results)
