The relationship between the pathogenesis of chronic liver diseases and skeletal muscle steatosis determined by computed tomography

• Project/Area Number: 22590741
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Saga University
• Principal Investigator: EGUCHI Yuuichiro 佐賀大学, 医学部, 教授 (80343341)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
• Keywords: 骨格筋脂肪化 / NASH / NAFLD / 非アルコール性脂肪性肝疾患 / 非アルコール性脂肪肝炎 / 肝硬変 / アルブミン / 筋年齢 / インスリン抵抗性 / 運動療法 / 非アルコール性脂肪性肝疾 / 骨格筋 / NAFIC score / 線維化 / フェリチン / IV型コラーゲン7S

Research Abstract

Aim: This study composed to clarify the relationship between the pathogenesis of chronic liver diseases and skeletal muscle steatosis determined by computed tomography. Conclusion: This study found that 1) there was an association between histological stage in nonalcoholic steatohepatitis and skeletal muscle steatosis, 2) there was an progression in skeletal muscle steatosis, and administration of branched chain amino acid granule improved skeletal muscle steatosis in decompensated liver cirrhosis.

Research Products

• [Journal Article] Japan Nonalcoholic Fatty Liver Disease Study Group (JSG-NAFLD). The severity of nonalcoholic steatohepatitis is associated with substitution of adipose tissue in skeletal muscle (2013)
  • Author(s): Kitajima Y, Hyogo H, Sumida Y, Eguchi Y, Ono N, Kuwashiro T, Tanaka K, Takahashi H, Mizuta T, Ozaki I, Eguchi T, Kimura Y, Fujimoto K, Anzai K
  • Journal Title: J Gastroenterol Hepatol Volume: Epub ahead of print] Issue: 9 Pages: 1-29
  • DOI: 10.1111/jgh.12227
  • Peer Reviewed
• [Journal Article] Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan : a multicenter large retrospective study (2012)
  • Author(s): Eguchi Y, Hyogo H, Ono M, Mizuta T, Ono N, Fujimoto K, Chayama K, Saibara T, Jsg N
  • Journal Title: J Gastroenterol Volume: (in press) Issue: 5 Pages: 586-595
  • DOI: 10.1007/s00535-012-0533-z
  • NAID: 10030650741
  • Peer Reviewed
• [Journal Article] The pathological role of visceral fat accumulation in steatosis, inflammation, and progression of nonalcoholic fatty liver disease (2011)
  • Author(s): Eguchi Y, Mizuta T, Sumida Y, Ishibashi E, Kitajima Y, Isoda H, Horie H, Tashiro T, Iwamoto E, Takahashi H, Kuwashiro T, Soejima S, Kawaguchi Y, Oda Y, Emura S, Iwakiri R, Ozaki I, Eguchi T, Ono N, Anzai K, Fujimoto K, Koizumi S
  • Journal Title: J Gastroenterol Volume: 1 Issue: S1 Pages: 70-8
  • DOI: 10.1007/s00535-010-0340-3
  • NAID: 10029030366
  • Peer Reviewed
• [Journal Article] Age-related fat deposition in multifidus muscle could be a marker for nonalcoholic fatty liver disease (2010)
  • Author(s): Kitajima Y, Eguchi Y, Ishibashi E, Nakashita S, Aoki S, Toda S, Mizut a T, Ozaki I, Ono N, Eguchi T, Arai K, Iwakiri R, Fujimoto K
  • Journal Title: J Gastroentero Volume: 45(2) Issue: 2 Pages: 218-24
  • DOI: 10.1007/s00535-009-0147-2
  • NAID: 10027214665
  • Peer Reviewed
• [Journal Article] The pathological role of visceral fat accumulation in steatosis, inflammation, and progression of nonalcoholic fatty liver disease. (2010)
  • Author(s): Eguchi Y, Mizuta T, Sumida Y, et al
  • Journal Title: Journal of Gastroenterology Volume: 46 Pages: 70-78
  • NAID: 10029030366
  • Peer Reviewed
• [Presentation] 分岐鎖アミノ酸は肝と骨格筋に作用し肝硬変の病態を改善する (2012)
  • Author(s): 北島陽一郎、江口有一郎、磯田広史、石橋絵里子、桑代卓也、高橋宏和、岩根紳治、水田敏彦、尾崎岩太、小野尚文、江口尚久、秋山巧、川添聖治、角田圭雄、安西慶三、藤本一眞
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: 石川県立音楽堂
• [Presentation] NAFLD/NASHに対する運動療法の効果判定と問題点 (2012)
  • Author(s): 北島陽一郎、江口有一郎、水田敏彦、桑代卓也、田中賢一、高橋宏和、尾崎岩太、小野尚文、江口尚久、角田圭雄、兵庫秀幸、安西慶三、藤本一眞
  • Organizer: 第33回日本肥満学会
  • Place of Presentation: ホテルグランヴィア京都
• [Presentation] 非代償性肝硬変患者の骨格筋脂質代謝に対するBCAA製剤の作用について (2011)
  • Author(s): 北島陽一郎
  • Organizer: 日本肝臓学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2011-10-23
• [Presentation] 非アルコール性脂肪性肝疾患の進展には骨格筋の糖代謝と加齢が影響する-骨格筋脂肪化進展と非侵襲的肝線維化予測モデルによる検討 (2011)
  • Author(s): 北島陽一郎、江口有一郎、水田敏彦、磯田広史、桑代卓也、高橋宏和、尾崎岩太、安西慶三、藤本一眞、小泉俊三、岡田倫明、小野尚文、江口尚久、角田圭雄、木村友希、兵庫秀幸
  • Organizer: 第19回肝病態生理研究会
  • Place of Presentation: ホテル日航東京
  • Year and Date: 2011-06-01
• [Presentation] Visceral fat accumulation is the first and second hit pathogenesis for development of nonalcoholic fatty liver disease. (2010)
  • Author(s): Eguchi Y, Mizuta T, Kawaguchi Y, et al
  • Organizer: The 2nd International Forum of the 96th Annual Meeting of the Japanese Society of Gastroenterology
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-23
• [Book] 症例に学ぶNASH/NAFLDの診断と治療-臨床で役立つ症例32 (2012)
  • Author(s): 岡上武、米田正人、角田圭雄、江口有一郎
  • Total Pages: 228
  • Publisher: 診断と治療社
• [Book] 症例に学ぶNASH/NAFLDの診断と治療―臨床で役立つ症例32 (2012)
  • Author(s): 岡上 武
  • Total Pages: 228
  • Publisher: 診断と治療社
• [Book] 内臓肥満による脂肪組織機能不全と非アルコール性脂肪性肝疾患(NAFLD)の発症と進展
  • Author(s): 江口有一郎、兵庫秀幸、小野正文