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The relationship between the pathogenesis of chronic liver diseases and skeletal muscle steatosis determined by computed tomography

Research Project

Project/Area Number 22590741
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionSaga University

Principal Investigator

EGUCHI Yuuichiro  佐賀大学, 医学部, 教授 (80343341)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Keywords骨格筋脂肪化 / NASH / NAFLD / 非アルコール性脂肪性肝疾患 / 非アルコール性脂肪肝炎 / 肝硬変 / アルブミン / 筋年齢 / インスリン抵抗性 / 運動療法 / 非アルコール性脂肪性肝疾 / 骨格筋 / NAFIC score / 線維化 / フェリチン / IV型コラーゲン7S
Research Abstract

Aim: This study composed to clarify the relationship between the pathogenesis of chronic liver diseases and skeletal muscle steatosis determined by computed tomography. Conclusion: This study found that 1) there was an association between histological stage in nonalcoholic steatohepatitis and skeletal muscle steatosis, 2) there was an progression in skeletal muscle steatosis, and administration of branched chain amino acid granule improved skeletal muscle steatosis in decompensated liver cirrhosis.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (13 results)

All 2013 2012 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (5 results) Book (3 results)

  • [Journal Article] Japan Nonalcoholic Fatty Liver Disease Study Group (JSG-NAFLD). The severity of nonalcoholic steatohepatitis is associated with substitution of adipose tissue in skeletal muscle2013

    • Author(s)
      Kitajima Y, Hyogo H, Sumida Y, Eguchi Y, Ono N, Kuwashiro T, Tanaka K, Takahashi H, Mizuta T, Ozaki I, Eguchi T, Kimura Y, Fujimoto K, Anzai K
    • Journal Title

      J Gastroenterol Hepatol

      Volume: Epub ahead of print] Issue: 9 Pages: 1-29

    • DOI

      10.1111/jgh.12227

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan : a multicenter large retrospective study2012

    • Author(s)
      Eguchi Y, Hyogo H, Ono M, Mizuta T, Ono N, Fujimoto K, Chayama K, Saibara T, Jsg N
    • Journal Title

      J Gastroenterol

      Volume: (in press) Issue: 5 Pages: 586-595

    • DOI

      10.1007/s00535-012-0533-z

    • NAID

      10030650741

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The pathological role of visceral fat accumulation in steatosis, inflammation, and progression of nonalcoholic fatty liver disease2011

    • Author(s)
      Eguchi Y, Mizuta T, Sumida Y, Ishibashi E, Kitajima Y, Isoda H, Horie H, Tashiro T, Iwamoto E, Takahashi H, Kuwashiro T, Soejima S, Kawaguchi Y, Oda Y, Emura S, Iwakiri R, Ozaki I, Eguchi T, Ono N, Anzai K, Fujimoto K, Koizumi S
    • Journal Title

      J Gastroenterol

      Volume: 1 Issue: S1 Pages: 70-8

    • DOI

      10.1007/s00535-010-0340-3

    • NAID

      10029030366

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-related fat deposition in multifidus muscle could be a marker for nonalcoholic fatty liver disease2010

    • Author(s)
      Kitajima Y, Eguchi Y, Ishibashi E, Nakashita S, Aoki S, Toda S, Mizut a T, Ozaki I, Ono N, Eguchi T, Arai K, Iwakiri R, Fujimoto K
    • Journal Title

      J Gastroentero

      Volume: 45(2) Issue: 2 Pages: 218-24

    • DOI

      10.1007/s00535-009-0147-2

    • NAID

      10027214665

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The pathological role of visceral fat accumulation in steatosis, inflammation, and progression of nonalcoholic fatty liver disease.2010

    • Author(s)
      Eguchi Y, Mizuta T, Sumida Y, et al
    • Journal Title

      Journal of Gastroenterology

      Volume: 46 Pages: 70-78

    • NAID

      10029030366

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 分岐鎖アミノ酸は肝と骨格筋に作用し肝硬変の病態を改善する2012

    • Author(s)
      北島陽一郎、江口有一郎、磯田広史、石橋絵里子、桑代卓也、高橋宏和、岩根紳治、水田敏彦、尾崎岩太、小野尚文、江口尚久、秋山巧、川添聖治、角田圭雄、安西慶三、藤本一眞
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      石川県立音楽堂
    • Related Report
      2012 Final Research Report
  • [Presentation] NAFLD/NASHに対する運動療法の効果判定と問題点2012

    • Author(s)
      北島陽一郎、江口有一郎、水田敏彦、桑代卓也、田中賢一、高橋宏和、尾崎岩太、小野尚文、江口尚久、角田圭雄、兵庫秀幸、安西慶三、藤本一眞
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都
    • Related Report
      2012 Final Research Report
  • [Presentation] 非代償性肝硬変患者の骨格筋脂質代謝に対するBCAA製剤の作用について2011

    • Author(s)
      北島陽一郎
    • Organizer
      日本肝臓学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2011-10-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患の進展には骨格筋の糖代謝と加齢が影響する-骨格筋脂肪化進展と非侵襲的肝線維化予測モデルによる検討2011

    • Author(s)
      北島陽一郎、江口有一郎、水田敏彦、磯田広史、桑代卓也、高橋宏和、尾崎岩太、安西慶三、藤本一眞、小泉俊三、岡田倫明、小野尚文、江口尚久、角田圭雄、木村友希、兵庫秀幸
    • Organizer
      第19回肝病態生理研究会
    • Place of Presentation
      ホテル日航東京
    • Year and Date
      2011-06-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Visceral fat accumulation is the first and second hit pathogenesis for development of nonalcoholic fatty liver disease.2010

    • Author(s)
      Eguchi Y, Mizuta T, Kawaguchi Y, et al
    • Organizer
      The 2nd International Forum of the 96th Annual Meeting of the Japanese Society of Gastroenterology
    • Place of Presentation
      新潟市
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Book] 症例に学ぶNASH/NAFLDの診断と治療-臨床で役立つ症例322012

    • Author(s)
      岡上武、米田正人、角田圭雄、江口有一郎
    • Total Pages
      228
    • Publisher
      診断と治療社
    • Related Report
      2012 Final Research Report
  • [Book] 症例に学ぶNASH/NAFLDの診断と治療―臨床で役立つ症例322012

    • Author(s)
      岡上 武
    • Total Pages
      228
    • Publisher
      診断と治療社
    • Related Report
      2012 Annual Research Report
  • [Book] 内臓肥満による脂肪組織機能不全と非アルコール性脂肪性肝疾患(NAFLD)の発症と進展

    • Author(s)
      江口有一郎、兵庫秀幸、小野正文
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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