| Project/Area Number |
22590742
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
IDO Akio 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (30291545)
|
|---|
| Research Collaborator |
OKETANI Makoto 鹿児島大学, 医学部・歯学部附属病院, 講師 (50274816)
UTO Hirofumi 鹿児島大学, 大学院・・医歯学総合研究科, 講師 (20347058)
MORIUCHI Akihiro 鹿児島大学, 医学部・歯学部附属病院, 助教 (40359823)
TAMAI Tsutomu 鹿児島大学, 医学部・歯学部附属病院, 特任講師 (10343336)
KUMAGAI Koutarou 鹿児島大学, 医学部・歯学部付属病院, 特任助教 (80626664)
TABU Kazuaki 鹿児島大学, 医学部・歯学部付属病院, 医員
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | オステオアクチビン / 肝障害 / 肝発癌 / 肝再生 / マクロファージ / 炎症性発癌 / 四塩化炭素 / 自然免疫 / 貪食 |
|---|
| Research Abstract |
In this study, we investigated an involvement of osteoacitivin, which is expressed in infiltrating macrophages, in repair of injured livers and hepatocarcinogenesis. In mice with CCl4-induced liver injury, osteoactivin was expressed in macrophages infiltrating in injured livers during repair process, and macrophages positive for osteoactivin exhibited enhanced ability of phagocytosis. When macrophages were depleted, repair of injured livers was suppressed. Additionally, mice lacking osteoactivin expression showed inhibition of both fibrosis and its resolution. When hepatoma cells were inoculated, following induction of liver injury, enhanced development of hepatic tumors was observed. These results suggest that osteoactivin play an important role in repair of injured livers and also in development of hepatocellular carcinoma occurring in the context of liver injury.
|
