Pathogenesis of autoimmune hepatic injury through the migration of immunocompetent cells into the liver
Project/Area Number |
22590744
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Keio University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KANAI Takanori 慶應義塾大学, 医学部, 准教授 (40245478)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 肝臓学 / 急性肝障害 / マクロファージ / ケモカイン受容体 / 免疫学 / トランスレーショナルリサーチ |
Research Abstract |
Liver-infiltrating CCR9^+macrophages play a key role in promoting proliferation of CD4^+ T cells and generation of IFN-γ-producing Th1 cells as well as NKT cell activation in Concanavalin A-induced acute hepatitis. In terms of the clinical relevance, not
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis.2012
Author(s)
Nakamoto N, Ebinuma H, Kanai T, Chu PS, Ono Y, Mikami Y, Ojiro K, Lipp M, Love PE, Saito H, Hibi T.
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Journal Title
Gastroenterology
Volume: 142
Pages: 366-376
Related Report
Peer Reviewed
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[Journal Article] CCR9(+) plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice.2012
Author(s)
Mizuno S, Kanai T, Mikami Y, Sujino T, Ono Y, Hayashi A, Handa T,Matsumoto A, Nakamoto N, Matsuoka K, Hisamatsu T, Takaishi H, Hibi T.
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Journal Title
Immunol Lett
Volume: 146
Pages: 64-69
Related Report
Peer Reviewed
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