Pathogenesis of autoimmune hepatic injury through the migration of immunocompetent cells into the liver

• Project/Area Number: 22590744
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: NAKAMOTO Nobuhiro 慶應義塾大学, 医学部, 助教 (40383749)
• Co-Investigator(Kenkyū-buntansha): KANAI Takanori 慶應義塾大学, 医学部, 准教授 (40245478)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 肝臓学 / 急性肝障害 / マクロファージ / ケモカイン受容体 / 免疫学 / トランスレーショナルリサーチ

Research Abstract

Liver-infiltrating CCR9^+macrophages play a key role in promoting proliferation of CD4^+ T cells and generation of IFN-γ-producing Th1 cells as well as NKT cell activation in Concanavalin A-induced acute hepatitis. In terms of the clinical relevance, not

Research Products

• [Journal Article] CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis. (2012)
  • Author(s): Nakamoto N, Ebinuma H, Kanai T, Chu PS, Ono Y, Mikami Y, Ojiro K, Lipp M, Love PE, Saito H, Hibi T.
  • Journal Title: Gastroenterology Volume: 142 Pages: 366-376
  • Peer Reviewed
• [Journal Article] CCR9(+) plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice. (2012)
  • Author(s): Mizuno S, Kanai T, Mikami Y, Sujino T, Ono Y, Hayashi A, Handa T,Matsumoto A, Nakamoto N, Matsuoka K, Hisamatsu T, Takaishi H, Hibi T.
  • Journal Title: Immunol Lett Volume: 146 Pages: 64-69
  • Peer Reviewed
• [Journal Article] CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis (2012)
  • Author(s): Nobuhiro Nakamoto, et.al.
  • Journal Title: Gastroenterology Volume: 142 Issue: 2 Pages: 366-376
  • DOI: 10.1053/j.gastro.2011.10.039
  • Peer Reviewed
• [Presentation] マウスCon A急性肝不全モデルでの病因性CCR9陽性マクロファージの発見から、肝臓各病態形成への関与 (2013)
  • Author(s): 中本伸宏
  • Organizer: 日本消化器病学会総会
  • Place of Presentation: 鹿児島
• [Presentation] Newly identified TNF-α-producing CCR9+ macrophages induce acute liver inflammation in mice (2011)
  • Author(s): Nobuhiro Nakamoto et.al
  • Organizer: 62nd Annual Meeting of the AASLD
  • Place of Presentation: San Francisco,USA
  • Year and Date: 2011-11-08
• [Presentation] Newly identified TNF-α-producing CCR9^+ macrophages induce acute liver inflammation in mice (2011)
  • Author(s): Nobuhiro Nakamoto, et.al.
  • Organizer: 62^<nd> Annual Meeting of the AASLD
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2011-11-08
• [Presentation] 自己免疫応答性急性肝障害の病態形成におけるCCR9 陽性マクロファージの役割 (2011)
  • Author(s): 中本伸宏
  • Organizer: 第97回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-14
• [Presentation] マウスPlasmacytoid DCの肝臓免疫寛容への関与 (2010)
  • Author(s): 中本伸宏
  • Organizer: 第38回日本肝臓学会東部会
  • Place of Presentation: 東京
  • Year and Date: 2010-12-03
• [Presentation] マウス肝臓内免疫担当細胞の免疫寛容への関与 (2010)
  • Author(s): 中本伸宏
  • Organizer: 第38回日本肝臓学会東部会
  • Place of Presentation: 東京・京王プラザホテル
  • Year and Date: 2010-12-03